Dlg4 - discs large MAGUK scaffold protein 4 Gene

种属: Mus musculus

同用名: Dlgh4; PSD95; SAP90; PSD-95; SAP90A

基因 ID: 13385 | 基因类型: protein coding

关于 Dlg4

功能概要

Enables ionotropic glutamate receptor binding activity and scaffold protein binding activity. Involved in several processes, including dendritic spine morphogenesis; locomotory exploration behavior; and neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within protein localization to synapse; regulation of long-term neuronal synaptic plasticity; and synaptic vesicle maturation. Located in several cellular components, including axon; postsynaptic density membrane; and synaptic vesicle. Is extrinsic component of cytoplasmic side of plasma membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Colocalizes with postsynaptic membrane. Is expressed in central nervous system; dorsal root ganglion; olfactory epithelium; and retina. Used to study Williams-Beuren syndrome and autism spectrum disorder. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human DLG4 (discs large MAGUK scaffold protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Dlg4 基因产物(6)

mRNA	Protein	Name
NM_001109752.1	NP_001103222.1	disks large homolog 4 isoform 2
NM_001370671.1	NP_001357600.1	disks large homolog 4 isoform 3
NM_001370672.1	NP_001357601.1	disks large homolog 4 isoform 4
NM_001370674.1	NP_001357603.1	disks large homolog 4 isoform 5
NM_001370675.1	NP_001357604.1	disks large homolog 4 isoform 6 precursor
NM_007864.3	NP_031890.1	disks large homolog 4 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ionotropic glutamate receptor binding	IPI IPI: 通过物理相互作用推断	15207857	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	9458051	MGI
enables scaffold protein binding	IPI IPI: 通过物理相互作用推断	16606358	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to potassium ion	IDA IDA: 通过直接分析推断	26609151	MGI
involved in dendritic spine morphogenesis	IDA IDA: 通过直接分析推断	20952458	MGI
involved in locomotory exploration behavior	IMP IMP: 通过突变表型推断	20952458	MGI
involved in neuromuscular process controlling balance	IMP IMP: 通过突变表型推断	20952458	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: 通过直接分析推断	17046693	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IEP IEP: 通过表达模式推断	17046693	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: 通过突变表型推断	17046693	MGI
acts upstream of or within protein localization to synapse	IDA IDA: 通过直接分析推断	15978582	MGI
involved in regulation of grooming behavior	IMP IMP: 通过突变表型推断	20952458	MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity	IGI IGI: 通过遗传相互作用推断	12427827	MGI
involved in social behavior	IMP IMP: 通过突变表型推断	20952458	MGI
acts upstream of or within synaptic vesicle maturation	IDA IDA: 通过直接分析推断	15603741	MGI
acts upstream of or within synaptic vesicle maturation	IGI IGI: 通过遗传相互作用推断	15603741	MGI
involved in vocalization behavior	IMP IMP: 通过突变表型推断	20952458	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of AMPA glutamate receptor complex	IDA IDA: 通过直接分析推断	15883194	MGI
located in cell junction	IDA IDA: 通过直接分析推断	21920314	MGI
located in cell periphery	IDA IDA: 通过直接分析推断	16828986	MGI
located in cerebellar mossy fiber	IDA IDA: 通过直接分析推断	23791195	MGI
located in cytoplasm	IDA IDA: 通过直接分析推断	11483650	MGI
located in dendrite	IDA IDA: 通过直接分析推断	23395379	MGI
located in dendritic spine	IDA IDA: 通过直接分析推断	24464040	MGI
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	16814779	MGI
located in excitatory synapse	IDA IDA: 通过直接分析推断	16980967	MGI
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	17046693	MGI
located in glutamatergic synapse	IDA IDA: 通过直接分析推断	37261953	MGI
is active in glutamatergic synapse	IEP IEP: 通过表达模式推断	17046693	MGI
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	17046693	MGI
located in juxtaparanode region of axon	IDA IDA: 通过直接分析推断	19109503	MGI
located in membrane	IDA IDA: 通过直接分析推断	15082773	MGI
located in neuron projection terminus	IDA IDA: 通过直接分析推断	12115694	MGI
located in neuron spine	IDA IDA: 通过直接分析推断	16606358	MGI
located in plasma membrane	IDA IDA: 通过直接分析推断	11483650	MGI
located in postsynapse	IDA IDA: 通过直接分析推断	25709106	MGI
located in postsynaptic density	IDA IDA: 通过直接分析推断	15317856	MGI
colocalizes with postsynaptic membrane	IDA IDA: 通过直接分析推断	15207857	MGI
located in synapse	IDA IDA: 通过直接分析推断	12972605	MGI
located in synapse	IMP IMP: 通过突变表型推断	23424281	MGI
located in synaptic membrane	IDA IDA: 通过直接分析推断	23595732	MGI
located in synaptic vesicle	IDA IDA: 通过直接分析推断	16520334	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

disks large homolog 4

PSD-95 alpha 2b	PSD-95 beta
SAP-90	discs large homolog 4
discs, large homolog 4	postsynaptic density protein 95
synapse-associated protein 90

Dlg4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	Dlg4	Q62108	Ablim1	Mus musculus	Q8K4G5	Anti Bait CoIP	19455133
Intra	Dlg4	Q62108	Ablim1	Mus musculus	Q8K4G5	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Ablim1	Mus musculus	Q8K4G5	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Gda	Mus musculus	Q9R111	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Gda	Mus musculus	Q9R111	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Gda	Mus musculus	Q9R111	Anti Bait CoIP	19022416
Intra	Dlg4	Q62108	Gda	Mus musculus	Q9R111	Anti Bait CoIP	19455133
Intra	Dlg4	Q62108	Kcna4	Mus musculus	Q61423	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Kcna4	Mus musculus	Q61423	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Neto1	Mus musculus	Q8R4I7	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Neto1	Mus musculus	Q8R4I7	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Neto1	Mus musculus	Q8R4I7	Anti Bait CoIP	19243221
Intra	Dlg4	Q62108	Lrp2	Mus musculus	A2ARV4	Y2H	10827173
Intra	Dlg4	Q62108	Lrp1	Mus musculus	Q91ZX7	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Lrp1	Mus musculus	Q91ZX7	Y2H	10827173
Intra	Dlg4	Q62108	Lrp1	Mus musculus	Q91ZX7	Pull Down	10827173
Intra	Dlg4	Q62108	Lrp1	Mus musculus	Q91ZX7	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Ntrk2	Mus musculus	P15209	Anti Bait CoIP	23424281
Intra	Dlg4	Q62108	Dlg3	Mus musculus	P70175	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Dlg3	Mus musculus	P70175	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Mapk1	Mus musculus	P63085	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Mapk1	Mus musculus	P63085	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Arc	Mus musculus	Q9WV31	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Arc	Mus musculus	Q9WV31	Anti Bait CoIP	23424281
Intra	Dlg4	Q62108	Arc	Mus musculus	Q9WV31	Anti Bait CoIP	19455133
Intra	Dlg4	Q62108	Arc	Mus musculus	Q9WV31	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Nsf	Mus musculus	P46460	Anti Bait CoIP	19455133
Intra	Dlg4	Q62108	Nsf	Mus musculus	P46460	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Nsf	Mus musculus	P46460	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Grin1	Mus musculus	P35438	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Grin1	Mus musculus	P35438	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Grin1	Mus musculus	P35438	Anti Bait CoIP	16601687
Intra	Dlg4	Q62108	Grin1	Mus musculus	P35438	Anti Bait CoIP	19240213
Intra	Dlg4	Q62108	Grin1	Mus musculus	P35438	Anti Bait CoIP	19243221
Intra	Dlg4	Q62108	Grin2a	Mus musculus	P35436	Anti Bait CoIP	19243221
Intra	Dlg4	Q62108	Grin2a	Mus musculus	P35436	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Grin2a	Mus musculus	P35436	Crosslink	28713243
Intra	Dlg4	Q62108	Grin2a	Mus musculus	P35436	Anti Bait CoIP	19455133
Intra	Dlg4	Q62108	Grin2a	Mus musculus	P35436	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Grin2a	Mus musculus	P35436	Anti Bait CoIP	28604739
Intra	Dlg4	Q62108	Grin2b	Mus musculus	Q01097	Pull Down	17950729
Intra	Dlg4	Q62108	Grin2b	Mus musculus	Q01097	Anti Bait CoIP	19243221
Intra	Dlg4	Q62108	Grin2b	Mus musculus	Q01097	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Grin2b	Mus musculus	Q01097	Anti Bait CoIP	16710293
Intra	Dlg4	Q62108	Grin2b	Mus musculus	Q01097	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Grin2b	Mus musculus	Q01097	Anti Bait CoIP	28604739
Intra	Dlg4	Q62108	Grin2b	Mus musculus	Q01097	Anti Bait CoIP	19455133
Intra	Dlg4	Q62108	Dlg2	Mus musculus	Q91XM9	Anti Bait CoIP	19455133
Intra	Dlg4	Q62108	Dlg2	Mus musculus	Q91XM9	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Dlg2	Mus musculus	Q91XM9	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Camk2a	Mus musculus	P11798	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Camk2a	Mus musculus	P11798	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Rac1	Mus musculus	P63001	Anti Bait CoIP	19455133
Intra	Dlg4	Q62108	Rac1	Mus musculus	P63001	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Lrp8	Mus musculus	Q924X6	Anti Tag CoIP	16332682
Intra	Dlg4	Q62108	Dlg1	Mus musculus	Q811D0	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Dlg1	Mus musculus	Q811D0	Anti Bait CoIP	19455133
Intra	Dlg4	Q62108	Dlg1	Mus musculus	Q811D0	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Mdm2	Mus musculus	P23804	Anti Bait CoIP	23260144
Intra	Dlg4	Q62108	Sh3kbp1	Mus musculus	Q8R550	Density Sedimentation	20551902
Intra	Dlg4	Q62108	Pcdh10	Mus musculus	Q80TE2	Anti Bait CoIP	23260144
Intra	Dlg4	Q62108	Pcdh10	Mus musculus	Q80TE2	Confocal	23260144
Intra	Dlg4	Q62108	Sstr1	Mus musculus	P30873	Pull Down	17950729
Intra	Dlg4	Q62108	Sstr4	Mus musculus	P49660	Pull Down	17950729
Intra	Dlg4	Q62108	Baiap2	Mus musculus	Q8BKX1	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Baiap2	Mus musculus	Q8BKX1	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Nrcam	Mus musculus	Q810U4	Pull Down	16882004
Intra	Dlg4	Q62108	Nrcam	Mus musculus	Q810U4	Y2H Array	16882004
Intra	Dlg4	Q62108	Fzd7	Mus musculus	Q61090	Imaging	12067714
Intra	Dlg4	Q62108	Fzd7	Mus musculus	Q61090	Anti Tag CoIP	12067714
Intra	Dlg4	Q62108	Fzd7	Mus musculus	Q61090	Y2H Array	12067714
Intra	Dlg4	Q62108	Lrfn2	Mus musculus	Q80TG9	Anti Bait CoIP	16495444

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03799	DLG4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Dlg4	NCBI	NCBI:1742
Rattus norvegicus	Dlg4	NCBI	NCBI:29495

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Dlg4 - discs large MAGUK scaffold protein 4 Gene

关于 Dlg4

功能概要

Dlg4 基因产物(6)

Dlg4 蛋白互作信息

直系同源

热门区域

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Dlg4 - discs large MAGUK scaffold protein 4 Gene

关于 Dlg4

功能概要

Dlg4 基因产物(6)

Dlg4 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z