2. Gene
  3. Lrp8 - low density lipoprotein receptor-related protein 8, apolipoprotein e receptor Gene

Lrp8 - low density lipoprotein receptor-related protein 8, apolipoprotein e receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Lr8b; ApoER2; 4932703M08Rik

基因 ID: 16975 | 基因类型: protein coding

关于 Lrp8

功能概要

Enables several functions, including amyloid-beta binding activity; Apolipoprotein binding activity; and reelin receptor activity. Involved in several processes, including nervous system development; positive regulation of CREB transcription factor activity; and regulation of dendrite development. Acts upstream of or within central nervous system development and positive regulation of protein kinase activity. Located in cell surface and extracellular space. Is expressed in nervous system and retina layer. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; dementia; myocardial infarction; and schizophrenia. Orthologous to human LRP8 (LDL receptor related protein 8). [provided by Alliance of Genome Resources, Apr 2022]

Lrp8 基因产物(6)

mRNA Protein Name
NM_001080926.1 NP_001074395.1 low-density lipoprotein receptor-related protein 8 isoform b precursor
NM_001369051.1 NP_001355980.1 low-density lipoprotein receptor-related protein 8 isoform c precursor
NM_001369052.1 NP_001355981.1 low-density lipoprotein receptor-related protein 8 isoform d
NM_001369053.1 NP_001355982.1 low-density lipoprotein receptor-related protein 8 isoform e
NM_001369054.1 NP_001355983.1 low-density lipoprotein receptor-related protein 8 isoform e
NM_053073.3 NP_444303.2 low-density lipoprotein receptor-related protein 8 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables amyloid-beta binding IPI
IPI: 通过物理相互作用推断
16227578 MGI
enables apolipoprotein binding IDA
IDA: 通过直接分析推断
10571240 MGI
enables calcium-dependent protein binding IPI
IPI: 通过物理相互作用推断
10571240 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10571240 MGI
enables reelin receptor activity IDA
IDA: 通过直接分析推断
10571241 MGI
enables reelin receptor activity IMP
IMP: 通过突变表型推断
18778775 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ammon gyrus development IMP
IMP: 通过突变表型推断
18778775 MGI
involved in chemical synaptic transmission IMP
IMP: 通过突变表型推断
18778775 MGI
involved in dendrite morphogenesis IMP
IMP: 通过突变表型推断
18778775 MGI
acts upstream of or within hippocampus development IGI
IGI: 通过遗传相互作用推断
17330141 MGI
acts upstream of or within layer formation in cerebral cortex IGI
IGI: 通过遗传相互作用推断
17330141 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
18778775 MGI
involved in positive regulation of dendrite development IGI
IGI: 通过遗传相互作用推断
18778775 MGI
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: 通过突变表型推断
21852430 MGI
acts upstream of or within positive regulation of protein kinase activity IGI
IGI: 通过遗传相互作用推断
12526740 MGI
involved in reelin-mediated signaling pathway IDA
IDA: 通过直接分析推断
10571241 MGI
involved in reelin-mediated signaling pathway IMP
IMP: 通过突变表型推断
18778775 MGI
involved in regulation of apoptotic process IMP
IMP: 通过突变表型推断
29336888 MGI
involved in regulation of innate immune response IMP
IMP: 通过突变表型推断
29336888 MGI
involved in regulation of postsynaptic neurotransmitter receptor activity IDA
IDA: 通过直接分析推断
16102539 MGI
involved in regulation of postsynaptic neurotransmitter receptor activity IMP
IMP: 通过突变表型推断
16102539 MGI
involved in ventral spinal cord development IEP
IEP: 通过表达模式推断
20711475 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
16102539 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
16102539 MGI
located in cell surface IDA
IDA: 通过直接分析推断
16227578 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
15950758 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
16102539 MGI
is active in glutamatergic synapse IEP
IEP: 通过表达模式推断
16102539 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
16102539 MGI
is active in postsynaptic density membrane IDA
IDA: 通过直接分析推断
16102539 MGI
is active in postsynaptic density membrane IEP
IEP: 通过表达模式推断
16102539 MGI
is active in postsynaptic density membrane IMP
IMP: 通过突变表型推断
16102539 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

low-density lipoprotein receptor-related protein 8

apolipoprotein E receptor 2

low density lipoprotein receptor relative, 8 ligand binding repeats, brain

Lrp8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Lrp8 Q924X6 Dlg4 Mus musculus Q62108
Anti Tag CoIP
16332682
种属内
Lrp8 Q924X6 Grin1 Mus musculus P35438
Anti Bait CoIP
16332682
种属内
Lrp8 Q924X6 Reln Mus musculus Q60841
Anti Bait CoIP
10571241
种属内
Lrp8 Q924X6 Reln Mus musculus Q60841
Pull Down
10571241
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07802 LRP8 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lrp8 NCBI NCBI:7804
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