2. Gene
  3. Arc - activity regulated cytoskeletal-associated protein Gene

Arc - activity regulated cytoskeletal-associated protein Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: mArc; Arc3.1; arg3.1

基因 ID: 11838 | 基因类型: protein coding

关于 Arc

功能概要

Predicted to enable mRNA binding activity. Involved in long-term memory; regulation of postsynaptic neurotransmitter receptor internalization; and regulation of synaptic plasticity. Acts upstream of or within anterior/posterior pattern specification and endoderm development. Located in several cellular components, including dendritic spine; glutamatergic synapse; and neuronal ribonucleoprotein granule. Is expressed in several structures, including central nervous system; extraembryonic component; metanephros; pancreas mesenchyme; and retina. Orthologous to human ARC (activity regulated Cytoskeleton associated protein). [provided by Alliance of Genome Resources, Apr 2022]

Arc 基因产物(2)

mRNA Protein Name
NM_001276684.1 NP_001263613.1 activity-regulated cytoskeleton-associated protein
NM_018790.3 NP_061260.1 activity-regulated cytoskeleton-associated protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19455133 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within anterior/posterior pattern specification IMP
IMP: 通过突变表型推断
10727859 MGI
acts upstream of or within endoderm development IMP
IMP: 通过突变表型推断
10727859 MGI
involved in long-term memory IMP
IMP: 通过突变表型推断
31151856 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
31151856 MGI
involved in regulation of long-term synaptic depression IDA
IDA: 通过直接分析推断
29264923 MGI
involved in regulation of long-term synaptic potentiation IMP
IMP: 通过突变表型推断
31151856 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: 通过直接分析推断
17088211 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: 通过突变表型推断
17088211 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite IDA
IDA: 通过直接分析推断
23936366 MGI
located in dendritic spine IDA
IDA: 通过直接分析推断
31151856 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
17088211 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
17088211 MGI
located in membrane raft IDA
IDA: 通过直接分析推断
29264923 MGI
located in neuronal ribonucleoprotein granule IDA
IDA: 通过直接分析推断
23936366 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

activity-regulated cytoskeleton-associated protein

ARC/ARG3.1

activity-regulated gene 3.1 protein homolog

Arc 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Arc Q9WV31 Camk2b Mus musculus P28652
Anti Bait CoIP
22579289
种属内
Arc Q9WV31 P49769-PRO_0000025597 Mus musculus P49769-PRO_0000025597
Anti Bait CoIP
22036569
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Approval
生物活性分子 (6)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10064 Ticagrelor Antagonist 99.98% 是
HY-147080 Avacincaptad pegol sodium Inhibitor 98.53% 否
HY-B0678 Metaxalone 99.77% 否
HY-16216 Gabapentin enacarbil Inhibitor ≥95.0% 是
HY-19638 Cangrelor Antagonist / 否
HY-B0678R Metaxalone (Standard) / 否
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-147079 Egaptivon pegol Inhibitor 92.75% Phase 2
HY-153480 ARC19499 Inhibitor 93.65% Phase 1
HY-19845 Ordopidine Antagonist / Phase 1
Pre-clinical Phase
生物活性分子 (35)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13248 AR-C155858 Inhibitor 99.62% 否
HY-110126 AR-C118925XX Antagonist ≥99.0% 否
HY-12709A ARC 239 dihydrochloride Antagonist 99.57% 否
HY-126112 Mephenoxalone 98.57% 否
HY-12122A AR-C102222 hydrochloride Inhibitor 99.83% 否
HY-N2673 5-Heptadecylresorcinol Activator 99.83% 否
HY-153785 NH2-C6-ARC186 sodium Inhibitor 92.50% 否
HY-153098 ARC186 Inhibitor 94.13% 否
HY-153480A ARC19499 sodium Inhibitor 93.65% 否
HY-153098A ARC186 sodium Inhibitor 94.13% 否
HY-119996A AR-C141990 hydrochloride Inhibitor ≥98.0% 否
HY-12709 ARC 239 99.71% 否
HY-77734 AR-C133913XX 99.76% 否
HY-108633 BYK 49187 Inhibitor / 否
HY-108665 AR-C66096 tetrasodium / 否
HY-119996 AR-C141990 Inhibitor / 否
HY-124270 Sibenadet hydrochloride Agonist / 否
HY-146769 Antimalarial agent 11 Inhibitor / 否
HY-147079A Egaptivon pegol sodium Inhibitor 92.75% 否
HY-153492A Olpasiran sodium Inhibitor / 否
HY-153610 ARC7 99.57% 否
HY-153611 ARC12 ≥99.0% 否
HY-78542 Deshydroxyethoxy ticagrelor Inhibitor / 否
HY-78542S Deshydroxyethoxy Ticagrelor-d7 / 否
HY-B0678S Metaxalone-d3 ≥98.0% 否
HY-B0678S1 Metaxalone-d6 / 否
HY-P4889 (Gly22)-amyloid beta-protein(1-40) / 否
HY-RS00890 ARC Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W350004 (+)-Arabinogalactan,from larch wood, 80% / 否
HY-107567B Carcinine dihydrochloride Antagonist 99.39% 否
HY-114602 AR-C117977 Inhibitor / 否
HY-118942 Topovale Inhibitor / 否
HY-12122 AR-C102222 Inhibitor / 否
HY-122048 AR-C67085 / 否
HY-148826 Rovunaptabin Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Arc NCBI NCBI:23237
Macaca fascicularis Arc NCBI NCBI:102130416
Canis lupus familiaris Arc NCBI
Rattus norvegicus Arc NCBI NCBI:54323
Macaca mulatta Arc NCBI NCBI:702690
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