Arc - activity-regulated cytoskeleton-associated protein Gene

种属: Rattus norvegicus

同用名: rg3.1

基因 ID: 54323 | 基因类型: protein coding

关于 Arc

功能概要

Enables mRNA binding activity. Involved in several processes, including learning or memory; positive regulation of AMPA Receptor activity; and regulation of synaptic plasticity. Located in actin Cytoskeleton and extracellular vesicle. Is active in glutamatergic synapse; postsynaptic density membrane; and postsynaptic endosome. Biomarker of middle cerebral artery infarction and visual epilepsy. Orthologous to human ARC (activity regulated Cytoskeleton associated protein). [provided by Alliance of Genome Resources, Apr 2022]

Arc 基因产物(1)

mRNA	Protein	Name
NM_019361.2	NP_062234.2	activity-regulated cytoskeleton-associated protein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables mRNA binding	IDA IDA: 通过直接分析推断	29328916	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	22036569	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in learning	IEP IEP: 通过表达模式推断	20111591	RGD
involved in long-term memory	IMP IMP: 通过突变表型推断	10818134	RGD
involved in mRNA transport	IDA IDA: 通过直接分析推断	29328916	RGD
involved in modulation of chemical synaptic transmission	IDA IDA: 通过直接分析推断	17898216	RGD
involved in modulation of chemical synaptic transmission	IMP IMP: 通过突变表型推断	17898216	RGD
involved in positive regulation of AMPA receptor activity	IMP IMP: 通过突变表型推断	17088211	RGD
involved in protein homooligomerization	IDA IDA: 通过直接分析推断	29328916	RGD
involved in regulation of dendritic spine morphogenesis	IGI IGI: 通过遗传相互作用推断	15537891	RGD
involved in regulation of long-term synaptic potentiation	IMP IMP: 通过突变表型推断	10818134	RGD
involved in regulation of neuronal synaptic plasticity	IEP IEP: 通过表达模式推断	7857651	RGD
involved in response to cocaine	IEP IEP: 通过表达模式推断	21590283	RGD
involved in response to ethanol	IEP IEP: 通过表达模式推断	18322102	RGD
involved in response to morphine	IEP IEP: 通过表达模式推断	21549764	RGD
involved in vesicle-mediated intercellular transport	IDA IDA: 通过直接分析推断	29328916	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in actin cytoskeleton	IDA IDA: 通过直接分析推断	7857651	RGD
located in extracellular vesicle	IDA IDA: 通过直接分析推断	29328916	RGD
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	17088211	RGD
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	17088211	RGD
is active in postsynaptic density membrane	IDA IDA: 通过直接分析推断	17088211	RGD
is active in postsynaptic density membrane	IMP IMP: 通过突变表型推断	17088211	RGD
is active in postsynaptic endosome	IDA IDA: 通过直接分析推断	17088211	RGD
is active in postsynaptic endosome	IMP IMP: 通过突变表型推断	17088211	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

activity-regulated cytoskeleton-associated protein

ARC/ARG3.1	activity regulated cytoskeletal-associated protein
activity-regulated gene 3.1 protein	arg3.1

Arc 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	Arc	Q63053	P49768-PRO_0000025591	Homo sapiens	P49768-PRO_0000025591	Anti Tag CoIP	22036569
种属内	Arc	Q63053	Camk2b	Rattus norvegicus	P08413	Y2H	22579289
种属内	Arc	Q63053	Camk2b	Rattus norvegicus	P08413	Confocal	22579289
种属内	Arc	Q63053	Camk2b	Rattus norvegicus	P08413	Anti Bait CoIP	22579289

种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Approval

生物活性分子 (6)

目录号	产品名	作用方式	纯度	是否罕见病
HY-10064	Ticagrelor	Antagonist	99.98%	是
HY-147080	Avacincaptad pegol sodium	Inhibitor	98.53%	否
HY-B0678	Metaxalone		99.77%	否
HY-16216	Gabapentin enacarbil	Inhibitor	≥95.0%	是
HY-19638	Cangrelor	Antagonist	/	否
HY-B0678R	Metaxalone (Standard)		/	否

Clinical Phase

生物活性分子 (3)

目录号	产品名	作用方式	纯度	Phase
HY-147079	Egaptivon pegol	Inhibitor	92.75%	Phase 2
HY-153480	ARC19499	Inhibitor	93.65%	Phase 1
HY-19845	Ordopidine	Antagonist	/	Phase 1

Pre-clinical Phase

生物活性分子 (35)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-13248	AR-C155858	Inhibitor	99.62%	否
HY-110126	AR-C118925XX	Antagonist	≥99.0%	否
HY-12709A	ARC 239 dihydrochloride	Antagonist	99.57%	否
HY-N2673	5-Heptadecylresorcinol	Activator	99.83%	否
HY-126112	Mephenoxalone		98.57%	否
HY-12122A	AR-C102222 hydrochloride	Inhibitor	99.83%	否
HY-153480A	ARC19499 sodium	Inhibitor	93.65%	否
HY-78542	Deshydroxyethoxy ticagrelor	Inhibitor	98.84%	否
HY-153785	NH2-C6-ARC186 sodium	Inhibitor	92.50%	否
HY-153098	ARC186	Inhibitor	94.13%	否
HY-153098A	ARC186 sodium	Inhibitor	94.13%	否
HY-119996A	AR-C141990 hydrochloride	Inhibitor	≥98.0%	否
HY-12709	ARC 239		99.71%	否
HY-147079A	Egaptivon pegol sodium	Inhibitor	92.75%	否
HY-77734	AR-C133913XX		99.76%	否
HY-108633	BYK 49187	Inhibitor	/	否
HY-108665	AR-C66096 tetrasodium		/	否
HY-119996	AR-C141990	Inhibitor	/	否
HY-122048	AR-C67085	Antagonist	/	否
HY-124270	Sibenadet hydrochloride	Agonist	/	否
HY-146769	Antimalarial agent 11	Inhibitor	/	否
HY-153492A	Olpasiran sodium	Inhibitor	/	否
HY-153610	ARC7		99.57%	否
HY-153611	ARC12		≥99.0%	否
HY-78542S	Deshydroxyethoxy Ticagrelor-d7		/	否
HY-B0678S	Metaxalone-d3		≥98.0%	否
HY-B0678S1	Metaxalone-d6		/	否
HY-P4889	(Gly22)-amyloid beta-protein(1-40)		/	否
HY-RS00890	ARC Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W350004	(+)-Arabinogalactan,from larch wood, 80%		/	否
HY-107567B	Carcinine dihydrochloride	Antagonist	99.39%	否
HY-114602	AR-C117977	Inhibitor	/	否
HY-118942	Topovale	Inhibitor	/	否
HY-12122	AR-C102222	Inhibitor	/	否
HY-148826	Rovunaptabin	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Arc	NCBI	NCBI:23237
Macaca fascicularis	Arc	NCBI	NCBI:102130416
Canis lupus familiaris	Arc	NCBI
Mus musculus	Arc	NCBI	NCBI:11838
Macaca mulatta	Arc	NCBI	NCBI:702690

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4