1. Gene
  2. CTSO - cathepsin O Gene

CTSO - cathepsin O Gene

中文名称:组织蛋白酶 O

种属: Homo sapiens

同用名: CTSO1

基因 ID: 1519 | 基因类型: protein coding

关于 CTSO

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:155,924,118-155,953,866 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 213 orthologues and 12 paralogues. Ubiquitous expression in gall bladder (RPKM 28.4), liver (RPKM 26.2) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种半胱氨酸蛋白酶,是木瓜蛋白酶超家族的成员。这种蛋白水解酶参与细胞蛋白质降解和周转。该酶的重组形式显示可降解通常用作半胱氨酸蛋白酶底物的合成肽,并且其蛋白水解活性被半胱氨酸蛋白酶抑制剂消除。[RefSeq 提供,2008 年 7 月]

The protein encoded by the gene is a cysteine proteinase and a member of the papain superfamily. This proteolytic Enzyme is involved in cellular protein degradation and turnover. The recombinant form of this Enzyme was shown to degrade synthetic Peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase. [provided by RefSeq, Jul 2008]

CTSO 基因产物(1)

mRNA Protein Name
NM_001334.3 NP_001325.1 cathepsin O preproprotein
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CTSO 蛋白结构

Peptidase_C1

Peptidase_C1: Papain family cysteine protease (108 - 318)

  • 0
  • 100
  • 200
  • 300
  • 321 a.a.
蛋白主名 其他名称

cathepsin O

CTSO 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CTSO P43234 LMO3 Homo sapiens Q8TAP4-4 32814053
种属内
CTSO P43234 LMO3 Homo sapiens Q8TAP4-4 32814053
种属内
CTSO P43234 LMO3 Homo sapiens Q8TAP4-4 32814053
种属内
CTSO P43234 PRKCA Homo sapiens P17252 32814053
种属内
CTSO P43234 PRKCA Homo sapiens P17252 32814053
种属内
CTSO P43234 PRKCA Homo sapiens P17252 32814053
种属内
CTSO P43234 YWHAG Homo sapiens P61981 32814053
种属内
CTSO P43234 YWHAG Homo sapiens P61981 32814053
种属内
CTSO P43234 YWHAG Homo sapiens P61981 32814053
种属内
CTSO P43234 KAT5 Homo sapiens Q92993 32814053
种属内
CTSO P43234 KAT5 Homo sapiens Q92993 32814053
种属内
CTSO P43234 KAT5 Homo sapiens Q92993 32814053
种属内
CTSO P43234 SETDB1 Homo sapiens Q15047-2 32814053
种属内
CTSO P43234 SETDB1 Homo sapiens Q15047-2 32814053
种属内
CTSO P43234 SETDB1 Homo sapiens Q15047-2 32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Orofaciodigital Syndrome V

OFD5

Thurston Syndrome

Orofaciodigital Syndrome 5

Polydactyly, Postaxial, With Median Cleft Of Upper Lip

Ofds V

Oral-Facial-Digital Syndrome, Type V

Orofaciodigital Syndrome, Thurston Type

Orofaciodigital Syndrome Thurston Type

Oral-Facial-Digital Syndrome 5

Polydactyly Postaxial With Median Cleft Of Upper Lip

Ofd Syndrome 5

Ofds 5

Oral Facial Digital Syndrome 5

Oral Facial Digital Syndrome Type 5

Orofaciodigital Syndrome Type 5

Oral-Facial-Digital Syndrome Type 5

Papillon-Leage And Psaume Syndrome

Orofaciodigital Syndrome, Type V

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus CTSO MGD MGI:2139628
Macaca mulatta CTSO VGNC VGNC:71561
Rattus norvegicus CTSO RGD RGD:1589156
Bos taurus CTSO VGNC VGNC:53898
Felis catus CTSO VGNC VGNC:61270