2. Gene
  3. Ido1 - indoleamine 2,3-dioxygenase 1 Gene

Ido1 - indoleamine 2,3-dioxygenase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：吲哚胺 2 ,3-双加氧酶 1

种属: Mus musculus

同用名: Ido; Indo

基因 ID: 15930 | 基因类型: protein coding

关于 Ido1

Chromosome 8: 25,074,152-25,087,025 reverse strand.GRCm39:CM001001.3

This gene has 2 transcripts (splice variants), 98 orthologues and is associated with 34 phenotypes. Biased expression in genital fat pad adult (RPKM 37.1), mammary gland adult (RPKM 7.7) and 2 other tissues.

功能概要

该基因编码的蛋白可启动色氨酸 2,3-双加氧酶活性。作用于多个过程的上游或内部，包括羧酸代谢过程；细胞凋亡过程的调节；和调节细胞因子的产生。位于平滑肌收缩纤维和静纤毛束中。在大脑皮层表达；纹状体；胚胎;胚外成分；和海马体。用于研究先兆子痫。与人类 IDO1（吲哚胺 2,3-双加氧酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables tryptophan 2,3-dioxygenase activity. Acts upstream of or within several processes, including carboxylic acid metabolic process; regulation of apoptotic process; and regulation of cytokine production. Located in smooth muscle contractile fiber and stereocilium bundle. Is expressed in cerebral cortex; corpus striatum; embryo; extraembryonic component; and hippocampus. Used to study pre-eclampsia. Orthologous to human IDO1 (indoleamine 2,3-dioxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ido1 基因产物(2)

mRNA Protein Name
NM_008324.3 NP_032350.1 indoleamine 2,3-dioxygenase 1 isoform 1
NM_001293690.2 NP_001280619.1 indoleamine 2,3-dioxygenase 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21804557 MGI
enables tryptophan 2,3-dioxygenase activity IDA
IDA: 通过直接分析推断
11751753 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of T cell proliferation IMP
IMP: 通过突变表型推断
18077788 MGI
acts upstream of or within cytokine production involved in inflammatory response IMP
IMP: 通过突变表型推断
19234212 MGI
acts upstream of or within inflammatory response IMP
IMP: 通过突变表型推断
18480171 MGI
acts upstream of interleukin-10 production IMP
IMP: 通过突变表型推断
19234212 MGI
acts upstream of interleukin-12 production IMP
IMP: 通过突变表型推断
19234212 MGI
acts upstream of or within kynurenic acid biosynthetic process IMP
IMP: 通过突变表型推断
19234212 MGI
acts upstream of or within multicellular organismal response to stress IMP
IMP: 通过突变表型推断
19234218 MGI
acts upstream of or within negative regulation of T cell apoptotic process IMP
IMP: 通过突变表型推断
18077788 MGI
acts upstream of or within negative regulation of T cell proliferation IMP
IMP: 通过突变表型推断
18077788 MGI
acts upstream of or within negative regulation of activated T cell proliferation IMP
IMP: 通过突变表型推断
18077788 MGI
acts upstream of or within negative regulation of interleukin-10 production IMP
IMP: 通过突变表型推断
19234212 MGI
acts upstream of or within positive regulation of T cell tolerance induction IMP
IMP: 通过突变表型推断
9712583 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
18480171 MGI
acts upstream of or within positive regulation of chronic inflammatory response IMP
IMP: 通过突变表型推断
18436652 MGI
acts upstream of or within positive regulation of interleukin-12 production IMP
IMP: 通过突变表型推断
19234212 MGI
acts upstream of or within positive regulation of type 2 immune response IMP
IMP: 通过突变表型推断
18436652 MGI
involved in quinolinate biosynthetic process IDA
IDA: 通过直接分析推断
2419335 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: 通过突变表型推断
19234212 MGI
acts upstream of or within swimming behavior IMP
IMP: 通过突变表型推断
19234218 MGI
acts upstream of or within tryptophan catabolic process to kynurenine IDA
IDA: 通过直接分析推断
2419335 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
17671174 MGI
located in smooth muscle contractile fiber IDA
IDA: 通过直接分析推断
19741271 MGI
located in stereocilium bundle IDA
IDA: 通过直接分析推断
19741271 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Ido1 蛋白结构

IDO

IDO: pfam01231 (15 - 401)

  • 0
  • 100
  • 200
  • 300
  • 407 a.a.
蛋白主名 其他名称

indoleamine 2,3-dioxygenase 1

IDO-1

indole 2,3-dioxygenase

indoleamine-pyrrole 2,3 dioxygenase

Ido1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Ido1 P28776 Ptpn11 Mus musculus P35235
Pull Down
21804557
种属内
Ido1 P28776 Ptpn11 Mus musculus P35235
Anti Bait CoIP
21804557
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 Ido1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72616 IDO-1 Protein, Mouse (His) P28776 (M1-P407) ≥95%

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-N0110 Palmatine chloride Inhibitor 99.81% 否
HY-N0110A Palmatine Inhibitor / 否
Clinical Phase
生物活性分子 (5)
目录号 产品名 作用方式
纯度 Phase
HY-15689 Epacadostat Inhibitor 99.66% Phase 3
HY-101560 Linrodostat Inhibitor 99.81% Phase 3
HY-139204 BMS-986242 Inhibitor 98.85% Phase 2
HY-101111 PF-06840003 Inhibitor 99.87% Phase 1
HY-13983 IDO-IN-7 Inhibitor 99.93% Phase 1
Pre-clinical Phase
生物活性分子 (28)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148383 DP00477 Inhibitor 99.03% 否
HY-N0110B Palmatine hydroxide Inhibitor 99.64% 否
HY-151108 IDO1/TDO-IN-4 Inhibitor 99.23% 否
HY-111540 LY-3381916 Inhibitor 99.92% 否
HY-131911 PROTAC IDO1 Degrader-1 Inhibitor 99.00% 否
HY-151093 IDO2-IN-1 Inhibitor 98.86% 否
HY-144652 IDO1-IN-19 Inhibitor 98.52% 否
HY-145280 IDO1/2-IN-1 Inhibitor 98.06% 否
HY-18769 BMS-978587 Inhibitor 99.92% 否
HY-78699 2-Hydrazinobenzothiazole Inhibitor 99.95% 否
HY-148572 NAMPT/IDO1-IN-1 Inhibitor / 否
HY-151886 NU223612 Inhibitor / 否
HY-144778 IDO1/TDO-IN-1 Inhibitor / 否
HY-144465 IDO1-IN-15 Inhibitor / 否
HY-161348 AT-0174 Inhibitor / 否
HY-120742 MMG-0358 Inhibitor / 否
HY-144468 IDO1-IN-17 Inhibitor / 否
HY-144274 IDO1-IN-14 Inhibitor / 否
HY-144466 IDO1-IN-16 Inhibitor / 否
HY-144273 IDO1-IN-13 Inhibitor / 否
HY-149227 IDO1-IN-21 Inhibitor / 否
HY-D0033 Roxyl-9 Inhibitor 99.22% 否
HY-158334 NDs-IN-1 Inhibitor / 否
HY-154387 1-Isopropyltryptophan Inhibitor / 否
HY-130607 IDO1-IN-2 Inhibitor / 否
HY-147772 ZC0101 Inhibitor / 否
HY-101560A Linrodostat mesylate Inhibitor / 否
HY-112147 IDO1 and HDAC1 Inhibitor Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ido1 NCBI NCBI:3620
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