DAO - D-amino acid oxidase Gene

中文名称：D-氨基酸氧化酶

种属: Homo sapiens

同用名: DAAO; OXDA; DAMOX

基因 ID: 1610 | 基因类型: protein coding

关于 DAO

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:108,880,092-108,901,043 (from NCBI)

This gene has 8 transcripts (splice variants), 215 orthologues, 1 paralogue and is associated with 1 phenotype. Biased expression in kidney (RPKM 37.6) and liver (RPKM 29.1).

功能概要

该基因编码过氧化物酶体酶 D-氨基酸氧化酶。该酶是一种黄素蛋白，它使用黄素腺嘌呤二核苷酸 (FAD) 作为其辅基。其底物包括多种 D-氨基酸，但对天然存在的 L-氨基酸无活性。其生物学功能尚不清楚；它可以作为一种解毒剂，去除在衰老过程中积累的 D-氨基酸。在小鼠中，它降解 D-丝氨酸，一种 NMDA 受体的共同激动剂。该基因可能在精神分裂症的病理生理学中发挥作用。[RefSeq 提供，2008 年 7 月]

This gene encodes the peroxisomal Enzyme D-amino acid oxidase. The Enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA Receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]

DAO 基因产物(3)

mRNA	Protein	Name
NM_001413634.1	NP_001400563.1	D-amino-acid oxidase isoform a
NM_001413635.1	NP_001400564.1	D-amino-acid oxidase isoform b
NM_001917.5	NP_001908.3	D-amino-acid oxidase isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables D-amino-acid oxidase activity	IDA IDA: 通过直接分析推断	12364586	GOA
enables D-amino-acid oxidase activity	IMP IMP: 通过突变表型推断	29274788	GOA
enables FAD binding	IDA IDA: 通过直接分析推断	16616139	GOA
enables FAD binding	IMP IMP: 通过突变表型推断	29274788	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16616139	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12364586	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in D-alanine catabolic process	IDA IDA: 通过直接分析推断	16616139	GOA
involved in D-amino acid catabolic process	IDA IDA: 通过直接分析推断	29274788	GOA
involved in D-serine catabolic process	IDA IDA: 通过直接分析推断	18544534	GOA
involved in D-serine metabolic process	IDA IDA: 通过直接分析推断	21679769	GOA
involved in dopamine biosynthetic process	IDA IDA: 通过直接分析推断	17303072	GOA
involved in proline catabolic process	IDA IDA: 通过直接分析推断	16616139	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	17880399	GOA
located in cytosol	IDA IDA: 通过直接分析推断	18544534	GOA
colocalizes with mitochondrial outer membrane	IDA IDA: 通过直接分析推断	21679769	GOA
located in peroxisomal matrix	IDA IDA: 通过直接分析推断	17684499	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DAO 蛋白结构

DAO

0
100
200
300
347 a.a.

蛋白主名

其他名称

D-amino-acid oxidase

DAO 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DAO	P14920	PRKAB2	Homo sapiens	O43741	Y2H Prey Pooling	25416956
种属内	DAO	P14920	PRKAB2	Homo sapiens	O43741	Y2H Array	31515488
种属内	DAO	P14920	KLHL42	Homo sapiens	Q9P2K6	Anti Tag CoIP	33961781
种属内	DAO	P14920	KLHL42	Homo sapiens	Q9P2K6	Anti Tag CoIP	28514442

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 DAO 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7898	D-amino-acid oxidase/DAO Protein, Human (His)	P14920 (M1-L347)	≥95%

关联疾病

疾病名称

别名

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Aging

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Schizoaffective Disorder

Schizo-Affective Psychosis	Schizo-Affective Type Schizophrenia
Schizoaffective Psychosis	Schizoaffective Schizophrenia
Schizophrenia, Schizo-Affective Type	Schizophreniform Psychosis, Affective Type

Schizotypal Personality Disorder

Schizotypal Personality

Molybdenum Cofactor Deficiency, Complementation Group B

MOCODB	Sulfite Oxidase Deficiency Due To Molybdenum Cofactor Deficiency Type B
Molybdenum Cofactor Deficiency B	Molybdenum Cofactor Deficiency Type B
Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase And Aldehyde Oxidase Type B	Mocod Type B
Molybdenum Cofactor Deficiency Complementation Group B	Deficiency, Molybdenum Cofactor, Complementation Group B

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-P2758	Diamine oxidase		/	Phase 4

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-117292	DAO-IN-2		99.83%	否
HY-W037417	DAO-IN-1	Inhibitor	97.46%	否
HY-15913	DAOS		99.88%	否
HY-RS03523	DAO Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W027382	SEP-227900		99.40%	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	DAO	VGNC	VGNC:39768
Bos taurus	DAO	VGNC	VGNC:27875
Macaca mulatta	DAO	VGNC	VGNC:71729
Rattus norvegicus	DAO	RGD	RGD:621138
Mus musculus	DAO	MGD	MGI:94859
Felis catus	DAO	VGNC	VGNC:61335
Others	DAO	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4