2. Gene
  3. Il1b - interleukin 1 beta Gene

Il1b - interleukin 1 beta Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：白介素 1β

种属: Mus musculus

同用名: Il-1b; IL-1beta

基因 ID: 16176 | 基因类型: protein coding

关于 Il1b

Chromosome 2: 129,206,490-129,213,059 reverse strand.GRCm39:CM000995.3

This gene has 3 transcripts (splice variants), 233 orthologues, 6 paralogues and is associated with 31 phenotypes. Broad expression in spleen adult (RPKM 1.3), lung adult (RPKM 1.) and 19 other tissues.

功能概要

该基因编码的蛋白质是白介素 1 细胞因子家族的成员。这种细胞因子由活化的巨噬细胞产生，作为一种前蛋白，它被半胱天冬酶 1 蛋白水解加工成其活性形式。编码的蛋白质在胸腺细胞增殖中起作用，并参与炎症反应。 [RefSeq 提供，2015 年 8 月]

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by Caspase 1. The encoded protein plays a role in thymocyte proliferation and is involved in the inflammatory response. [provided by RefSeq, Aug 2015]

Il1b 基因产物(1)

mRNA Protein Name
NM_008361.4 NP_032387.1 interleukin-1 beta
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cytokine activity IDA
IDA: 通过直接分析推断
12925700 MGI
enables receptor ligand activity IDA
IDA: 通过直接分析推断
16260493 MGI
enables receptor ligand activity IGI
IGI: 通过遗传相互作用推断
16260493 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of JNK cascade IDA
IDA: 通过直接分析推断
16260493 MGI
acts upstream of JNK cascade IGI
IGI: 通过遗传相互作用推断
16260493 MGI
acts upstream of or within astrocyte activation IDA
IDA: 通过直接分析推断
28377412 MGI
involved in cellular response to interleukin-17 IDA
IDA: 通过直接分析推断
30294880 MGI
acts upstream of or within ectopic germ cell programmed cell death IGI
IGI: 通过遗传相互作用推断
11536012 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: 通过突变表型推断
11536012 MGI
acts upstream of or within interleukin-1 beta production IGI
IGI: 通过遗传相互作用推断
19158679 MGI
acts upstream of interleukin-6 production IDA
IDA: 通过直接分析推断
15292196 MGI
acts upstream of or within interleukin-6 production IDA
IDA: 通过直接分析推断
15843532 MGI
acts upstream of or within leukocyte migration IDA
IDA: 通过直接分析推断
15034066 MGI
acts upstream of or within macrophage cytokine production IDA
IDA: 通过直接分析推断
15843532 MGI
involved in negative regulation of D-glucose transmembrane transport IDA
IDA: 通过直接分析推断
16865359 MGI
involved in negative regulation of MAP kinase activity IDA
IDA: 通过直接分析推断
16865359 MGI
involved in negative regulation of adiponectin secretion IDA
IDA: 通过直接分析推断
16865359 MGI
involved in negative regulation of insulin receptor signaling pathway IDA
IDA: 通过直接分析推断
16865359 MGI
involved in negative regulation of lipid metabolic process IDA
IDA: 通过直接分析推断
16865359 MGI
involved in negative regulation of synaptic transmission IMP
IMP: 通过突变表型推断
20739563 MGI
acts upstream of or within neutrophil chemotaxis IDA
IDA: 通过直接分析推断
12925700 MGI
acts upstream of or within positive regulation of JNK cascade IDA
IDA: 通过直接分析推断
16260493 MGI
acts upstream of or within positive regulation of JNK cascade IGI
IGI: 通过遗传相互作用推断
16260493 MGI
involved in positive regulation of JNK cascade IGI
IGI: 通过遗传相互作用推断
20739563 MGI
involved in positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
12598651 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
16260493 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IGI
IGI: 通过遗传相互作用推断
16260493 MGI
acts upstream of or within positive regulation of chemokine production IDA
IDA: 通过直接分析推断
12925700 MGI
involved in positive regulation of fever generation IDA
IDA: 通过直接分析推断
19940926 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: 通过直接分析推断
19666510 MGI
acts upstream of or within positive regulation of interleukin-6 production IDA
IDA: 通过直接分析推断
12925700 MGI
involved in positive regulation of interleukin-6 production IDA
IDA: 通过直接分析推断
20554964 MGI
involved in positive regulation of lipid catabolic process IDA
IDA: 通过直接分析推断
16865359 MGI
involved in positive regulation of p38MAPK cascade IGI
IGI: 通过遗传相互作用推断
20739563 MGI
involved in positive regulation of prostaglandin secretion IDA
IDA: 通过直接分析推断
19940926 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19734906 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
19666510 MGI
involved in positive regulation of vascular endothelial growth factor production IMP
IMP: 通过突变表型推断
12598651 MGI
involved in regulation of defense response to virus by host IDA
IDA: 通过直接分析推断
24784232 MGI
involved in regulation of nitric-oxide synthase activity IDA
IDA: 通过直接分析推断
15899045 MGI
acts upstream of or within response to ATP IDA
IDA: 通过直接分析推断
15905573 MGI
acts upstream of or within response to ATP IMP
IMP: 通过突变表型推断
18490713 MGI
acts upstream of or within response to carbohydrate IDA
IDA: 通过直接分析推断
16301672 MGI
acts upstream of or within response to lipopolysaccharide IDA
IDA: 通过直接分析推断
16423834 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: 通过突变表型推断
18490713 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
11016935 MGI
located in secretory granule IDA
IDA: 通过直接分析推断
16423834 MGI
located in vesicle IDA
IDA: 通过直接分析推断
15905573 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Il1b 蛋白结构

IL1_propep

IL1_propep: pfam02394 (0 - 101)

IL1

IL1: smart00125 (119 - 264)

  • 0
  • 100
  • 200
  • 269 a.a.
蛋白主名 其他名称

interleukin-1 beta

IL-1 beta

重组 Il1b 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7073 IL-1 beta Protein, Mouse P10749 (V118-S269) ≥95%
HY-P7073A IL-1 beta Protein, Mouse (CHO) P10749 (V118-S269) ≥95%
HY-P700187AF Animal-Free IL-1 beta Protein, Mouse (His) P10749 (V118-S269) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P1137 10Panx Inhibitor 99.40% 否
HY-141852 STAMBP-IN-1 Inhibitor 98.37% 否
HY-P1117 MMK1 99.22% 否
HY-147105 LRH-1 modulator-1 Agonist 98.04% 否
HY-147105A (+)-LRH-1 modulator-1 / 否
HY-111662 Fc 11a-2 Inhibitor / 否
HY-162168 Anti-inflammatory agent 71 Inhibitor / 否
HY-N8936 Narchinol B / 否
HY-P1117A MMK1 TFA / 否
HY-RS06716 IL1B Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06717 Il1b Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06718 Il1b Rat Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P99139 Anti-Mouse IL-1b Antibody (B122) Inhibitor 95.00% 否
HY-P990563 CDP-484 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Il1b NCBI NCBI:3553
Canis familiaris Il1b NCBI NCBI:403974
Felis catus Il1b NCBI NCBI:768274
Macaca fascicularis Il1b NCBI NCBI:102119749
Susscrofa domestica Il1b NCBI
Leporidae Il1b NCBI
Rattus norvegicus Il1b NCBI NCBI:24494
Macaca mulatta Il1b NCBI NCBI:704701
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