1. Gene
  2. DBN1 - drebrin 1 Gene

DBN1 - drebrin 1 Gene

中文名称:德布林 1

种属: Homo sapiens

同用名: D0S117E

基因 ID: 1627 | 基因类型: protein coding

关于 DBN1

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,456,610-177,473,634 (from NCBI)

This gene has 11 transcripts (splice variants), 199 orthologues and 4 paralogues. Ubiquitous expression in endometrium (RPKM 21.1), brain (RPKM 16.5) and 24 other tissues.

功能概要

该基因编码的蛋白质是一种细胞质肌动蛋白结合蛋白,被认为在神经元生长过程中发挥作用。它是 drebrin 蛋白家族的成员,在大脑中受到发育调节。大脑中这种蛋白质数量的减少被认为是阿尔茨海默病记忆障碍发病机制的一个可能促成因素。至少有两种编码不同蛋白质亚型的选择性剪接变体已被描述用于该基因。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

DBN1 基因产物(7)

mRNA Protein Name
NM_001363541.2 NP_001350470.2 drebrin isoform c
NM_001364151.2 NP_001351080.2 drebrin isoform d
NM_001364152.2 NP_001351081.2 drebrin isoform e
NM_001393630.1 NP_001380559.1 drebrin isoform f
NM_001393631.1 NP_001380560.1 drebrin isoform g
NM_004395.4 NP_004386.3 drebrin isoform a
NM_080881.3 NP_543157.2 drebrin isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12577067 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cytoplasmic sequestering of protein IDA
IDA: 通过直接分析推断
28966017 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
8838578 GOA
located in cytoskeleton IDA
IDA: 通过直接分析推断
24327345 GOA
located in dendrite IDA
IDA: 通过直接分析推断
8838578 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DBN1 蛋白结构

Cofilin_ADF

Cofilin_ADF: Cofilin/tropomyosin-type actin-binding protein (12 - 133)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 649 a.a.
蛋白主名 其他名称

drebrin

developmentally-regulated brain protein

DBN1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DBN1 Q16643 AFDN Homo sapiens P55196
Anti Bait CoIP
23750010
种属内
DBN1 Q16643 AFDN Homo sapiens P55196
Confocal
23750010
种属内
DBN1 Q16643 GRB2 Homo sapiens P62993
Y2H Array
25814554
种属内
DBN1 Q16643 GRB2 Homo sapiens P62993
Lumier
25814554
种属内
DBN1 Q16643 CXCR4 Homo sapiens P61073
Pull Down
20215400
种属内
DBN1 Q16643 CXCR4 Homo sapiens P61073
Anti Bait CoIP
20215400
种属内
DBN1 Q16643 CXCR4 Homo sapiens P61073
Anti Bait CoIP
23926103
种属内
DBN1 Q16643 PTEN Homo sapiens P60484
Anti Tag CoIP
23940795
种属内
DBN1 Q16643 PTEN Homo sapiens P60484
FRET
23940795
种属内
DBN1 Q16643 TINF2 Homo sapiens Q9BSI4
Pull Down
21044950
种属内
DBN1 Q16643 TINF2 Homo sapiens Q9BSI4
BiFC
21044950
种属内
DBN1 Q16643 ZMYND8 Homo sapiens Q9ULU4
ITC
28966017
种属内
DBN1 Q16643 ZMYND8 Homo sapiens Q9ULU4
X-Ray Diffraction
28966017
种属内
DBN1 Q16643 ZMYND8 Homo sapiens Q9ULU4
GMS
28966017
种属内
DBN1 Q16643 ZMYND8 Homo sapiens Q9ULU4
Confocal
28966017
种属内
DBN1 Q16643 DBN1 Homo sapiens Q16643-1
Anti Tag CoIP
23750010
种属间: 跨种属相互作用 种属内: 同种属相互作用

DBN1 抗体

目录号 产品名 应用 反应物种
HY-P83573 Drebrin Antibody (YA3318) WB, ICC/IF, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21

Dyskeratosis Congenita, Autosomal Recessive 2

DKCB2

Autosomal Recessive Dyskeratosis Congenita 2

Dyskeratosis Congenita, Autosomal Recessive, 2

Dyskeratosis Congenita, Autosomal Recessive, Type 2

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus DBN1 VGNC VGNC:61347
Canis familiaris DBN1 VGNC VGNC:39783
Bos taurus DBN1 VGNC VGNC:27890
Rattus norvegicus DBN1 RGD RGD:70885
Mus musculus DBN1 MGD MGI:1931838
Macaca mulatta DBN1 VGNC VGNC:71742