2. Gene
  3. Itch - itchy, E3 ubiquitin protein ligase Gene

Itch - itchy, E3 ubiquitin protein ligase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: AIP4; A130065M08; 6720481N21Rik; 8030492O04Rik; C230047C07Rik

基因 ID: 16396 | 基因类型: protein coding

关于 Itch

功能概要

Enables Ligase activity. Involved in several processes, including negative regulation of JNK cascade; negative regulation of NF-kappaB transcription factor activity; and protein K48-linked ubiquitination. Acts upstream of or within several processes, including cellular protein metabolic process; negative regulation of alpha-beta T cell proliferation; and positive regulation of T cell anergy. Located in several cellular components, including cell cortex; cytoplasmic vesicle; and nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human ITCH (itchy E3 ubiquitin protein Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Itch 基因产物(2)

mRNA Protein Name
NM_001243712.1 NP_001230641.1 E3 ubiquitin-protein ligase Itchy
NM_008395.3 NP_032421.2 E3 ubiquitin-protein ligase Itchy
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ligase activity IMP
IMP: 通过突变表型推断
18246070 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11782481 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of CD4-positive, alpha-beta T cell proliferation IMP
IMP: 通过突变表型推断
14973438 MGI
acts upstream of T cell anergy IMP
IMP: 通过突变表型推断
14973438 MGI
acts upstream of or within negative regulation of CD4-positive, alpha-beta T cell proliferation IMP
IMP: 通过突变表型推断
14973438 MGI
involved in negative regulation of JNK cascade IMP
IMP: 通过突变表型推断
18246070 MGI
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
18246070 MGI
involved in negative regulation of defense response to virus IMP
IMP: 通过突变表型推断
19881509 MGI
acts upstream of or within positive regulation of T cell anergy IMP
IMP: 通过突变表型推断
14973438 MGI
acts upstream of or within positive regulation of protein catabolic process IDA
IDA: 通过直接分析推断
14973438 MGI
acts upstream of or within positive regulation of protein catabolic process IMP
IMP: 通过突变表型推断
14973438 MGI
involved in protein K48-linked ubiquitination IMP
IMP: 通过突变表型推断
18246070 MGI
acts upstream of protein catabolic process IMP
IMP: 通过突变表型推断
14973438 MGI
acts upstream of or within protein polyubiquitination IDA
IDA: 通过直接分析推断
14973438 MGI
involved in regulation of protein deubiquitination IMP
IMP: 通过突变表型推断
18246070 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
14973438 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell cortex IDA
IDA: 通过直接分析推断
17137798 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
14973438 MGI
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
17137798 MGI
located in membrane IDA
IDA: 通过直接分析推断
14973438 MGI
located in nucleus IDA
IDA: 通过直接分析推断
11555636 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

E3 ubiquitin-protein ligase Itchy

HECT-type E3 ubiquitin transferase Itchy homolog

Itch 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Itch Q8C863 Cyld Mus musculus Q80TQ2
Anti Bait CoIP
22057290
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Approval
生物活性分子 (4)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0548A Hydroxyzine dihydrochloride Antagonist 99.81% 否
HY-B1183 Hydrocortisone acetate Agonist 99.14% 是
HY-B0548 Hydroxyzine Antagonist 99.60% 否
HY-106566 Alclometasone dipropionate ≥96.0% 否
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99025 Lebrikizumab Inhibitor 99.90% 否
HY-P99162 Nemolizumab Inhibitor 99.70% 否
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-136642 Fluocinolone Agonist 99.66% Phase 4
HY-14939 Vapitadine / Phase 2
Pre-clinical Phase
生物活性分子 (26)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-129047 Trypsin Activator / 否
HY-103368 Eact Activator 98.14% 否
HY-148244 MS47134 99.88% 否
HY-118069 (R)-ZINC-3573 Agonist 99.81% 否
HY-129047A Trypsin (MS grade) Activator 95.00% 否
HY-103320A Calhex 231 hydrochloride Inhibitor 99.81% 否
HY-147051 Nelremagpran 99.64% 否
HY-145997 MRGPRX4 modulator-1 99.09% 否
HY-148949 Kallikrein 5-IN-2 98.69% 否
HY-B1144A Chlormidazole hydrochloride Inhibitor 98.98% 否
HY-P1192 GR-73632 Agonist 99.93% 否
HY-103320B (1R,2R)-Calhex 231 hydrochloride Control 99.07% 否
HY-145153 S-777469 Agonist 98.83% 否
HY-108425 AMG8379 Antagonist / 否
HY-108425B (Rac)-AMG8379 Antagonist / 否
HY-103320 Calhex 231 Antagonist / 否
HY-108425A AMG8380 Antagonist / 否
HY-124356 Alcaftadine carboxylic acid / 否
HY-135495 AM-0466 Inhibitor / 否
HY-143481 Nav1.8-IN-2 Inhibitor / 否
HY-157496 EP3 antagonist 7 Antagonist / 否
HY-163840 GFRα2/3-IN-1 Inhibitor / 否
HY-P5357 SFNGGP-NH2 / 否
HY-RS06943 ITCH Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-124356AS Alcaftadine carboxylic acid-d3 sodium / 否
HY-N12040 γ-Isofagarine / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Itch NCBI NCBI:83737
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