Ldlr - low density lipoprotein receptor Gene

种属: Mus musculus

同用名: Hlb301

基因 ID: 16835 | 基因类型: protein coding

关于 Ldlr

功能概要

Enables several functions, including amyloid-beta binding activity; low-density lipoprotein particle binding activity; and low-density lipoprotein particle receptor activity. Involved in several processes, including lipid transport; regulation of inflammatory response; and regulation of lipid metabolic process. Acts upstream of or within several processes, including Cholesterol homeostasis; lipoprotein catabolic process; and low-density lipoprotein particle clearance. Located in several cellular components, including basolateral plasma membrane; endosome; and lysosome. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; paravertebral ganglion; and sensory organ. Used to study familial hypercholesterolemia and fatty liver disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ldlr 基因产物(3)

mRNA	Protein	Name
NM_001252658.1	NP_001239587.1	low-density lipoprotein receptor isoform 2 precursor
NM_001252659.1	NP_001239588.1	low-density lipoprotein receptor isoform 3 presursor precursor
NM_010700.3	NP_034830.2	low-density lipoprotein receptor isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables amyloid-beta binding	IPI IPI: 通过物理相互作用推断	22383525	MGI
enables low-density lipoprotein particle binding	IDA IDA: 通过直接分析推断	7848292	MGI
enables low-density lipoprotein particle receptor activity	IDA IDA: 通过直接分析推断	12072432	MGI
enables low-density lipoprotein particle receptor activity	IMP IMP: 通过突变表型推断	17148552	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	12169628	MGI
enables very-low-density lipoprotein particle receptor activity	IDA IDA: 通过直接分析推断	16166565	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in amyloid-beta clearance	IGI IGI: 通过遗传相互作用推断	20005821	MGI
involved in amyloid-beta clearance by cellular catabolic process	IDA IDA: 通过直接分析推断	22383525	MGI
involved in artery morphogenesis	IMP IMP: 通过突变表型推断	22927332	MGI
involved in cellular response to fatty acid	IGI IGI: 通过遗传相互作用推断	24255059	MGI
acts upstream of or within cholesterol homeostasis	IGI IGI: 通过遗传相互作用推断	11120757	MGI
involved in cholesterol homeostasis	IGI IGI: 通过遗传相互作用推断	25524771	MGI
acts upstream of or within cholesterol homeostasis	IMP IMP: 通过突变表型推断	9788969	MGI
involved in cholesterol import	IMP IMP: 通过突变表型推断	18175806	MGI
acts upstream of or within cholesterol metabolic process	IMP IMP: 通过突变表型推断	17071966	MGI
acts upstream of or within cholesterol transport	IMP IMP: 通过突变表型推断	17148552	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: 通过突变表型推断	17148552	MGI
involved in high-density lipoprotein particle clearance	IGI IGI: 通过遗传相互作用推断	25524771	MGI
acts upstream of or within lipid metabolic process	IGI IGI: 通过遗传相互作用推断	11120757	MGI
acts upstream of or within lipoprotein catabolic process	IDA IDA: 通过直接分析推断	15741654	MGI
acts upstream of or within lipoprotein catabolic process	IMP IMP: 通过突变表型推断	9788969	MGI
acts upstream of or within lipoprotein metabolic process	IGI IGI: 通过遗传相互作用推断	11120757	MGI
involved in long-term memory	IGI IGI: 通过遗传相互作用推断	24412220	MGI
acts upstream of or within low-density lipoprotein particle clearance	IDA IDA: 通过直接分析推断	26965651	MGI
involved in low-density lipoprotein particle clearance	IMP IMP: 通过突变表型推断	18175806	MGI
involved in negative regulation of amyloid fibril formation	IGI IGI: 通过遗传相互作用推断	20005821	MGI
involved in negative regulation of astrocyte activation	IGI IGI: 通过遗传相互作用推断	20005821	MGI
involved in negative regulation of gene expression	IMP IMP: 通过突变表型推断	24255059	MGI
involved in negative regulation of microglial cell activation	IGI IGI: 通过遗传相互作用推断	20005821	MGI
involved in negative regulation of protein metabolic process	IDA IDA: 通过直接分析推断	22383525	MGI
involved in phagocytosis	IDA IDA: 通过直接分析推断	22383525	MGI
involved in phospholipid transport	IMP IMP: 通过突变表型推断	18175806	MGI
involved in plasma lipoprotein particle clearance	IDA IDA: 通过直接分析推断	22383525	MGI
involved in positive regulation of gene expression	IGI IGI: 通过遗传相互作用推断	24255059	MGI
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	24255059	MGI
involved in positive regulation of inflammatory response	IGI IGI: 通过遗传相互作用推断	24255059	MGI
involved in positive regulation of lysosomal protein catabolic process	IDA IDA: 通过直接分析推断	22383525	MGI
involved in positive regulation of triglyceride biosynthetic process	IMP IMP: 通过突变表型推断	18175806	MGI
involved in receptor-mediated endocytosis	IDA IDA: 通过直接分析推断	20005821	MGI
involved in regulation of cholesterol metabolic process	IGI IGI: 通过遗传相互作用推断	24412220	MGI
involved in regulation of phosphatidylcholine catabolic process	IMP IMP: 通过突变表型推断	18175806	MGI
involved in regulation of protein metabolic process	IGI IGI: 通过遗传相互作用推断	24412220	MGI
involved in response to caloric restriction	IGI IGI: 通过遗传相互作用推断	24412220	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in apical part of cell	IDA IDA: 通过直接分析推断	22848640	MGI
located in basolateral plasma membrane	IDA IDA: 通过直接分析推断	22848640	MGI
located in cell surface	IDA IDA: 通过直接分析推断	22848640	MGI
located in early endosome	IDA IDA: 通过直接分析推断	11092755	MGI
located in endosome	IDA IDA: 通过直接分析推断	12746448	MGI
located in late endosome	IDA IDA: 通过直接分析推断	11092755	MGI
located in lysosome	IDA IDA: 通过直接分析推断	11092755	MGI
located in plasma membrane	IDA IDA: 通过直接分析推断	20005821	MGI
located in somatodendritic compartment	IDA IDA: 通过直接分析推断	18341993	MGI
located in sorting endosome	IDA IDA: 通过直接分析推断	11092755	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

low-density lipoprotein receptor

LDL receptor

重组 Ldlr 蛋白

目录号	产品名	蛋白编号	纯度
HY-P73272	LDLR Protein, Mouse (HEK293, His)	P35951 (A22-R790)	≥95%
HY-P73838	LDLR Protein, Mouse (Biotinylated, A23V, C27G, HEK293, His)	P35951/NP_034830.2 (A22-R790, A23V, C27G)	≥95%

目录号	产品名	作用方式	纯度	Phase
HY-P4073	ANG1005		98.83%	Phase 3

目录号	产品名	作用方式	纯度	Phase
HY-P99822	Recaticimab		99.71%	Phase 3
HY-P99793	Orticumab	Inhibitor	≥99.0%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P2341	Angiopep-2 hydrochloride		99.74%	否
HY-NP013	Oxidized low density lipoprotein (mouse)		≥98.0%	否
HY-145001	20-HC-Me-Pyrrolidine	Inhibitor	97.66%	否
HY-101529	Imanixil		99.03%	否
HY-125544	LY 295427	Modulator	≥98.0%	否
HY-120651	LDL-IN-2	Inhibitor	≥99.0%	否
HY-100144	Pirozadil		98.31%	否
HY-NP012	Low density lipoprotein (human)		/	否
HY-U00054	LDL-IN-3	Inhibitor	/	否
HY-167873	Habenariol	Inhibitor	/	否
HY-P10502	L57		/	否
HY-P10698	VH-N412		/	否
HY-P10697	VH4127	Modulator	/	否
HY-126551	Butenoyl-PAF		/	否
HY-147279	Milpocitide		/	否
HY-161941	MeIm		/	否
HY-165512	Nicanartine	Inhibitor	/	否
HY-161938	BRD8518		/	否
HY-123260	S12340	Inhibitor	/	否
HY-159595	PCSK9-IN-29	Inducer	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990143	Anti-Mouse/Rat/Bovine VLDL-R Antibody (IgG-6A6)	Inhibitor	95.00%	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Ldlr	NCBI	NCBI:3949
Macaca fascicularis	Ldlr	NCBI	NCBI:102127361

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Ldlr - low density lipoprotein receptor Gene

关于 Ldlr

功能概要

Ldlr 基因产物(3)

重组 Ldlr 蛋白

直系同源

热门区域

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Ldlr - low density lipoprotein receptor Gene

关于 Ldlr

功能概要

Ldlr 基因产物(3)

重组 Ldlr 蛋白

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z