2. Gene
  3. Sphk1 - sphingosine kinase 1 Gene

Sphk1 - sphingosine kinase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：鞘氨醇激酶 1

种属: Rattus norvegicus

基因 ID: 170897 | 基因类型: protein coding

关于 Sphk1

Primary_assembly 10: 101,758,711-101,764,240 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 277 orthologues, 4 paralogues and is associated with 7 phenotypes. Biased expression in Thymus (RPKM 63.), Kidney (RPKM 34.3) and 7 other tissues.

功能概要

该基因编码的蛋白可启动 D-赤型-鞘氨醇激酶活性。参与多个过程，包括环氧合酶途径； NF-kappaB 转录因子活性的正调控；和大分子代谢过程的正向调控。位于多个细胞成分中，包括轴突；胞质溶胶；和突触小泡。腺癌和高级别胶质瘤的生物标志物。该基因的人类直系同源物与 2 型糖尿病有关。与人 SPHK1（鞘氨醇激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables D-erythro-sphingosine kinase activity. Involved in several processes, including cyclooxygenase pathway; positive regulation of NF-kappaB transcription factor activity; and positive regulation of macromolecule metabolic process. Located in several cellular components, including axon; cytosol; and synaptic vesicle. Biomarker of adenocarcinoma and high grade glioma. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SphK1 (sphingosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Sphk1 基因产物(6)

mRNA Protein Name
NM_001270809.1 NP_001257738.1 sphingosine kinase 1 isoform b
NM_001270807.1 NP_001257736.1 sphingosine kinase 1 isoform b
NM_001270808.1 NP_001257737.1 sphingosine kinase 1 isoform b
NM_133386.3 NP_596877.2 sphingosine kinase 1 isoform b
NM_001270811.1 NP_001257740.1 sphingosine kinase 1 isoform a
NM_001270810.1 NP_001257739.1 sphingosine kinase 1 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables D-erythro-sphingosine kinase activity IDA
IDA: 通过直接分析推断
15715670 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
16888242 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to growth factor stimulus IEP
IEP: 通过表达模式推断
16135093 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: 通过表达模式推断
17158340 RGD
involved in cellular response to starvation IEP
IEP: 通过表达模式推断
16959847 RGD
involved in cyclooxygenase pathway IDA
IDA: 通过直接分析推断
18723875 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
18723875 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
17158340 RGD
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
28284343 RGD
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
17200676 RGD
involved in positive regulation of interleukin-17 production IMP
IMP: 通过突变表型推断
28284343 RGD
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
15289497 RGD
involved in positive regulation of neurotransmitter secretion IMP
IMP: 通过突变表型推断
17325039 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
16313513 RGD
involved in regulation of neuroinflammatory response IMP
IMP: 通过突变表型推断
28284343 RGD
involved in regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: 通过突变表型推断
28284343 RGD
involved in response to ATP IEP
IEP: 通过表达模式推断
17200676 RGD
involved in response to amine IEP
IEP: 通过表达模式推断
17164439 RGD
involved in response to interleukin-1 IEP
IEP: 通过表达模式推断
15855330 RGD
involved in response to magnesium ion IEP
IEP: 通过表达模式推断
18028875 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
15715670 RGD
involved in response to progesterone IEP
IEP: 通过表达模式推断
17164439 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
17325039 RGD
located in synaptic vesicle IDA
IDA: 通过直接分析推断
17325039 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Sphk1 蛋白结构

PLN02958

PLN02958: cl29912 (85 - 418)

  • 0
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  • 458 a.a.
蛋白主名 其他名称

sphingosine kinase 1

SK 1

SPK 1

acetyltransferase SPHK1

相关产品

Pre-clinical Phase
生物活性分子 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15425 PF-543 Inhibitor 99.85% 否
HY-15425A PF-543 Citrate Inhibitor 99.47% 否
HY-124042 K6PC-5 Activator 99.27% 否
HY-12892 SKI-178 Inhibitor 98.91% 否
HY-101572 MHP Activator 98.23% 否
HY-147282 Amgen-23 Inhibitor 99.00% 否
HY-101805 SK1-IN-1 Inhibitor 98.72% 否
HY-119016A SK1-​I hydrochloride Inhibitor 99.49% 否
HY-148707 SphK1&2-IN-1 Inhibitor 99.33% 否
HY-148262 SphK1-IN-3 Inhibitor / 否
HY-150615 SphK1-IN-2 Inhibitor / 否
HY-143296 SphK1-IN-1 Inhibitor / 否
HY-12900 RB-005 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sphk1 NCBI NCBI:8877
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