Smad3 - SMAD family member 3 Gene

种属: Mus musculus

同用名: Madh3

基因 ID: 17127 | 基因类型: protein coding

关于 Smad3

功能概要

Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Involved in several processes, including JNK cascade; negative regulation of osteoblast proliferation; and positive regulation of chondrocyte differentiation. Acts upstream of or within several processes, including animal organ development; regulation of transcription by RNA polymerase II; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; limb; and nervous system. Used to study osteoarthritis. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic Cancer. Orthologous to human SMAD3 (Smad Family member 3). [provided by Alliance of Genome Resources, Apr 2022]

Smad3 基因产物(1)

mRNA	Protein	Name
NM_016769.4	NP_058049.3	mothers against decapentaplegic homolog 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	27336669	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IPI IPI: 通过物理相互作用推断	24964035	MGI
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	12943993	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	25065622	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	11937490	MGI
enables chromatin DNA binding	IDA IDA: 通过直接分析推断	16224064	MGI
enables chromatin binding	IDA IDA: 通过直接分析推断	16619037	MGI
enables collagen binding	IPI IPI: 通过物理相互作用推断	14559231	MGI
enables double-stranded DNA binding	IDA IDA: 通过直接分析推断	15282343	MGI
enables identical protein binding	IPI IPI: 通过物理相互作用推断	21724602	MGI
enables promoter-specific chromatin binding	IDA IDA: 通过直接分析推断	18802055	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	11711431	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in JNK cascade	IMP IMP: 通过突变表型推断	18802055	MGI
involved in MAPK cascade	IMP IMP: 通过突变表型推断	18802055	MGI
acts upstream of or within SMAD protein signal transduction	IGI IGI: 通过遗传相互作用推断	23390484	MGI
involved in T cell activation	IMP IMP: 通过突变表型推断	10064594	MGI
acts upstream of or within apoptotic process	IMP IMP: 通过突变表型推断	19679673	MGI
acts upstream of or within cell population proliferation	IGI IGI: 通过遗传相互作用推断	19679673	MGI
involved in cellular response to virus	IDA IDA: 通过直接分析推断	18802055	MGI
acts upstream of or within developmental growth	IGI IGI: 通过遗传相互作用推断	15183723	MGI
acts upstream of or within embryonic cranial skeleton morphogenesis	IGI IGI: 通过遗传相互作用推断	15183723	MGI
acts upstream of or within embryonic foregut morphogenesis	IGI IGI: 通过遗传相互作用推断	15183723	MGI
acts upstream of or within embryonic pattern specification	IGI IGI: 通过遗传相互作用推断	15183723	MGI
acts upstream of or within endoderm development	IGI IGI: 通过遗传相互作用推断	15183723	MGI
acts upstream of or within gastrulation	IGI IGI: 通过遗传相互作用推断	15183723	MGI
acts upstream of or within heart looping	IGI IGI: 通过遗传相互作用推断	15183723	MGI
acts upstream of or within immune system development	IGI IGI: 通过遗传相互作用推断	15183723	MGI
acts upstream of or within in utero embryonic development	IGI IGI: 通过遗传相互作用推断	15183723	MGI
acts upstream of or within lens fiber cell differentiation	IMP IMP: 通过突变表型推断	17215516	MGI
acts upstream of or within liver development	IGI IGI: 通过遗传相互作用推断	15183723	MGI
acts upstream of or within mesoderm formation	IMP IMP: 通过突变表型推断	15084457	MGI
involved in negative regulation of inflammatory response	IMP IMP: 通过突变表型推断	10559937	MGI
acts upstream of or within negative regulation of osteoblast differentiation	IGI IGI: 通过遗传相互作用推断	15150273	MGI
involved in negative regulation of osteoblast proliferation	IMP IMP: 通过突变表型推断	21035443	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	9702197	MGI
involved in negative regulation of wound healing	IMP IMP: 通过突变表型推断	10559937	MGI
acts upstream of or within osteoblast development	IGI IGI: 通过遗传相互作用推断	15150273	MGI
involved in osteoblast differentiation	IMP IMP: 通过突变表型推断	11585338	MGI
acts upstream of or within paraxial mesoderm morphogenesis	IMP IMP: 通过突变表型推断	15084457	MGI
acts upstream of or within pericardium development	IGI IGI: 通过遗传相互作用推断	15183723	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	15282343	MGI
involved in positive regulation of chondrocyte differentiation	IMP IMP: 通过突变表型推断	21035443	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	12943993	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	25065622	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	15150273	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	18802055	MGI
acts upstream of or within regulation of binding	IDA IDA: 通过直接分析推断	15282343	MGI
acts upstream of or within regulation of epithelial cell proliferation	IMP IMP: 通过突变表型推断	12845704	MGI
involved in regulation of immune response	IMP IMP: 通过突变表型推断	10064594	MGI
acts upstream of or within regulation of striated muscle tissue development	IDA IDA: 通过直接分析推断	11711431	MGI
acts upstream of or within regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: 通过直接分析推断	11711431	MGI
acts upstream of or within response to transforming growth factor beta	IGI IGI: 通过遗传相互作用推断	19679673	MGI
acts upstream of or within skeletal system development	IGI IGI: 通过遗传相互作用推断	15183723	MGI
acts upstream of or within somitogenesis	IMP IMP: 通过突变表型推断	15183723	MGI
acts upstream of or within thyroid gland development	IGI IGI: 通过遗传相互作用推断	15183723	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IDA IDA: 通过直接分析推断	15239668	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IMP IMP: 通过突变表型推断	15239668	MGI
involved in ureteric bud development	IEP IEP: 通过表达模式推断	14656760	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	11160896	MGI
located in nucleus	IDA IDA: 通过直接分析推断	11160896	MGI
located in plasma membrane	IDA IDA: 通过直接分析推断	12543979	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

mothers against decapentaplegic homolog 3

MAD homolog 3	Smad 3
mMad3	mad3
mothers against DPP homolog 3

Smad3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Smad3	Q8BUN5	Pou5f1	Mus musculus	P20263	Anti Bait CoIP	22036565
种属内	Smad3	Q8BUN5	Pou5f1	Mus musculus	P20263	CH-IP	22036565
种属内	Smad3	Q8BUN5	Pou5f1	Mus musculus	P20263	Crosslink	22036565
种属内	Smad3	Q8BUN5	Axin1	Mus musculus	O35625	Anti Tag CoIP	16601693
种属内	Smad3	Q8BUN5	Smad4	Mus musculus	P97471	Anti Bait CoIP	18268325
种属内	Smad3	Q8BUN5	Smad4	Mus musculus	P97471	Anti Bait CoIP	22045334
种属内	Smad3	Q8BUN5	Smad4	Mus musculus	P97471	Anti Bait CoIP	22036565
种属内	Smad3	Q8BUN5	Smad4	Mus musculus	P97471	PLA	22442258

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 Smad3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P73636	SMAD3 Protein, Human/Mouse/Rat (sf9, His-GST)	Q8BUN5 (M1-S425)	≥95%

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-13013	SIS3	Inhibitor	98.71%	否
HY-12953	R-268712	Inhibitor	99.88%	否
HY-W012977	3,3-Dimethyl-1-butanol	Inhibitor	99.56%	否
HY-N2033	Chebulinic acid	Inhibitor	99.68%	否
HY-47888	PLN-1474	Inhibitor	99.30%	否
HY-18758	IN-1130	Inhibitor	99.93%	否
HY-100444	SIS3 free base	Inhibitor	98.11%	否
HY-144043	ALK5-IN-8	Inhibitor	98.06%	否
HY-147025	(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine		99.06%	否
HY-121410	Narasin		≥98.0%	否
HY-163536	TGF-β1/Smad3-IN-1	Inhibitor	98.05%	否
HY-128439	BT173	Inhibitor	98.71%	否
HY-114683	KS370G	Inhibitor	99.71%	否
HY-146434	TGFβ-IN-2	Inhibitor	99.37%	否
HY-114495	Caerulomycin A	Inhibitor	≥98.0%	否
HY-W803134	(E/Z)-SIS3 free base	Inhibitor	99.48%	否
HY-P10363	Tiger17	Activator	/	否
HY-P10899	ETTAC-2	Inhibitor	/	否
HY-RS13394	SMAD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W108953	Myristoyl tetrapeptide-12	Activator	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Smad3	NCBI	NCBI:4088
Rattus norvegicus	Smad3	NCBI	NCBI:25631

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