2. Gene
  3. Smad3 - SMAD family member 3 Gene

Smad3 - SMAD family member 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: mad3; Madh3; Smad 3

基因 ID: 25631 | 基因类型: protein coding

关于 Smad3

功能概要

Enables several functions, including DNA-binding transcription factor activity; SMAD binding activity; and beta-catenin binding activity. Involved in several processes, including positive regulation of hydrolase activity; regulation of gene expression; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in cytoplasm and nucleus. Part of transcription regulator complex. Used to study pre-malignant neoplasm. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic Cancer. Orthologous to human SMAD3 (Smad Family member 3). [provided by Alliance of Genome Resources, Apr 2022]

Smad3 基因产物(1)

mRNA Protein Name
NM_013095.3 NP_037227.1 mothers against decapentaplegic homolog 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
12702545 RGD
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
22073128 RGD
enables beta-catenin binding IDA
IDA: 通过直接分析推断
20097766 RGD
enables enzyme binding IPI
IPI: 通过物理相互作用推断
22073128 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
16362038 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
12702545 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in SMAD protein signal transduction IMP
IMP: 通过突变表型推断
22073128 RGD
involved in activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
IMP: 通过突变表型推断
11839804 RGD
involved in adrenal gland development IDA
IDA: 通过直接分析推断
12844345 RGD
involved in cellular response to glucose stimulus IEP
IEP: 通过表达模式推断
32065356 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: 通过表达模式推断
33409963 RGD
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
14517210 RGD
involved in negative regulation of cardiac muscle hypertrophy in response to stress IGI
IGI: 通过遗传相互作用推断
27038547 RGD
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
15987742 RGD
involved in negative regulation of lung blood pressure IGI
IGI: 通过遗传相互作用推断
27038547 RGD
involved in negative regulation of protein catabolic process IDA
IDA: 通过直接分析推断
16690606 RGD
involved in negative regulation of protein catabolic process IMP
IMP: 通过突变表型推断
20097766 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16205635 RGD
involved in positive regulation of alkaline phosphatase activity IDA
IDA: 通过直接分析推断
12096832 RGD
involved in positive regulation of bone mineralization IDA
IDA: 通过直接分析推断
12096832 RGD
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
20097766 RGD
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
17545585 RGD
involved in positive regulation of focal adhesion assembly IDA
IDA: 通过直接分析推断
15987742 RGD
involved in positive regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
16371439 RGD
involved in positive regulation of nitric oxide biosynthetic process IGI
IGI: 通过遗传相互作用推断
27038547 RGD
involved in positive regulation of positive chemotaxis IDA
IDA: 通过直接分析推断
15987742 RGD
involved in positive regulation of stress fiber assembly IDA
IDA: 通过直接分析推断
15987742 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12702545 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16891311 RGD
involved in positive regulation of transforming growth factor beta3 production IMP
IMP: 通过突变表型推断
16891311 RGD
involved in protein stabilization IMP
IMP: 通过突变表型推断
20097766 RGD
involved in signal transduction involved in regulation of gene expression IMP
IMP: 通过突变表型推断
22073128 RGD
involved in transdifferentiation IDA
IDA: 通过直接分析推断
15987742 RGD
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
16371439 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
16690606 RGD
part of transcription regulator complex IDA
IDA: 通过直接分析推断
16891311 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

mothers against decapentaplegic homolog 3

MAD (mothers against decapentaplegic, Drosophila) homolog 3

MAD homolog 3

mothers against DPP homolog 3

Smad3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Smad3 P84025 Akt1 Rattus norvegicus P47196
Anti Tag CoIP
16362038
种属内
Smad3 P84025 Akt1 Rattus norvegicus P47196
Anti Bait CoIP
16362038
种属间
Smad3 P84025 N Human SARS coronavirus P59595
Pull Down
18055455
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (18)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13013 SIS3 Inhibitor 98.71% 否
HY-12953 R-268712 Inhibitor 99.88% 否
HY-W012977 3,3-Dimethyl-1-butanol Inhibitor 99.56% 否
HY-47888 PLN-1474 Inhibitor 99.30% 否
HY-18758 IN-1130 Inhibitor 99.93% 否
HY-N2033 Chebulinic acid Inhibitor 99.68% 否
HY-100444 SIS3 free base Inhibitor 98.11% 否
HY-144043 ALK5-IN-8 Inhibitor 98.06% 否
HY-147025 (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine 99.06% 否
HY-163536 TGF-β1/Smad3-IN-1 Inhibitor 98.05% 否
HY-114495 Caerulomycin A Inhibitor ≥98.0% 否
HY-128439 BT173 Inhibitor 98.71% 否
HY-114683 KS370G 99.71% 否
HY-146434 TGFβ-IN-2 Inhibitor 99.37% 否
HY-W803134 (E/Z)-SIS3 free base Inhibitor 99.48% 否
HY-P10363 Tiger17 Activator / 否
HY-RS13394 SMAD3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W108953 Myristoyl tetrapeptide-12 Activator / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Smad3 NCBI NCBI:4088
Mus musculus Smad3 NCBI NCBI:17127
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