Akt1 - AKT serine/threonine kinase 1 Gene

中文名称：AKT 丝氨酸/苏氨酸激酶 1

种属: Rattus norvegicus

同用名: Akt

关于 Akt1

功能概要

该基因编码的蛋白可启动多项功能，包括 ATP 绑定活动； GTP酶激活蛋白结合活性；和酶结合活性。参与多个过程，包括细胞大分子生物合成过程；细胞对机械刺激的反应；和调节细胞蛋白质代谢过程。作用于多个过程的上游或内部，包括细胞对胰岛素刺激的反应；细胞大小的负调节；钠离子转运的正向调节。位于胞质溶胶中；线粒体；和核。用于研究常染色体隐性多囊肾病；高血压;阳痿;心肌梗塞;和 2 型糖尿病。多种疾病的生物标志物，包括脑缺血；结肠癌;糖尿病性视网膜病变; 2型糖尿病；和输尿管梗阻。该基因的人类直系同源物与多种疾病有关，包括考登综合征 6；乳腺癌（多发性）；肺部疾病（多发）；胰腺癌（多发性）；和生殖器官癌（多发性）。与人类 AKT1（AKT 丝氨酸/苏氨酸激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ATP binding activity; GTPase activating protein binding activity; and Enzyme binding activity. Involved in several processes, including cellular macromolecule biosynthetic process; cellular response to mechanical stimulus; and regulation of cellular protein metabolic process. Acts upstream of or within several processes, including cellular response to Insulin stimulus; negative regulation of cell size; and positive regulation of sodium ion transport. Located in cytosol; mitochondrion; and nucleus. Used to study autosomal recessive polycystic kidney disease; hypertension; impotence; myocardial infarction; and type 2 diabetes mellitus. Biomarker of several diseases, including brain ischemia; colon cancer; diabetic retinopathy; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome 6; breast Cancer (multiple); lung disease (multiple); pancreatic Cancer (multiple); and reproductive organ Cancer (multiple). Orthologous to human Akt1 (Akt serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]