2. PROTAC PI3K/Akt/mTOR
  3. PROTACs Akt
  4. INY-03-041 trihydrochloride

INY-03-041 trihydrochloride 

目录号: HY-133120A 纯度: 99.27%
COA 产品使用指南

摩尔计算器

INY-03-041 trihydrochloride 是一种有效的、高选择性的、基于 PROTAC 的泛-AKT 降解剂，由ATP 竞争性 AKT 抑制剂Ipatasertib (HY-15186) 结合 Lenalidomide (HY-A0003，Cereblon 配体)组成。INY-03-041 trihydrochloride 可抑制 AKT1，AKT2 和 AKT3，IC50 分别为 2.0 nM，6.8 nM 和 3.5 nM。

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INY-03-041 trihydrochloride Chemical Structure

INY-03-041 trihydrochloride Chemical Structure

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3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥7900
In-stock
5 mg   询价  
10 mg   询价  

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Customer Review

Other Forms of INY-03-041 trihydrochloride:

INY-03-041 trihydrochloride 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

INY-03-041 trihydrochloride is a potent, highly selective and PROTAC-based pan-AKT degrader consisting of the ATP-competitive AKT inhibitor Ipatasertib (HY-15186) conjugated to Lenalidomide (HY-A0003, Cereblon ligand). INY-03-041 trihydrochloride inhibits AKT1, AKT2 and AKT3 with IC50s of 2.0, 6.8 and 3.5 nM, respectively[1].

IC50 & Target

Akt1

2.0 nM (IC50)

Akt3

3.5 nM (IC50)

Akt2

6.8 nM (IC50)

Cereblon

 

体外研究
(In Vitro)

INY-03-041 (10-1000 nM; 0-24 hours) induces potent degradation of all three AKT isoforms in MDA-MB-468 cells[1].
INY-03-041 exhibits potent in vitro inhibition of S6K1 (IC50 =37.3 nM) and PKG1 (IC50 = 33.2 nM)[1].
INY-03-041 displays enhanced anti-proliferative effects compared with Ipatasertib (HY-15186) in MDA-MB-468 and HCC1937 cells[1].
INY-03-041 (250 nM, 12 h) promotes sustained AKT degradation and inhibition of downstream signaling effects for up to 96 h, even after compound washout[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

INY-03-041 trihydrochloride 相关抗体:

Western Blot Analysis[1]

Cell Line: MDA-MB-468 cells
Concentration: 0, 10, 50, 100, 250, 500, and 1000 nM
Incubation Time: 0, 2, 4, 6, 8. 10, 12, and 24 h
Result: Induced potent degradation of all three AKT isoforms in a dose-dependent manner after a 12-h treatment, with maximal degradation observed between 100 and 250 nM. At concentrations of 500 nM and greater, AKT degradation is diminished. Treatment with 250 nM of INY-03-041 over time reveals partial degradation of all AKT isoforms within 4 h and progressive loss of AKT abundance out to 24 h.
分子量

907.80

Formula

C44H59Cl4N7O5
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 140 mg/mL (154.22 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1016 mL 5.5078 mL 11.0156 mL
5 mM 0.2203 mL 1.1016 mL 2.2031 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.27%

COA (262 KB) HNMR (252 KB) RP-HPLC (242 KB) MS (70 KB)

产品使用指南 (1538 KB)
参考文献

INY-03-041 trihydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1016 mL 5.5078 mL 11.0156 mL 27.5391 mL
5 mM 0.2203 mL 1.1016 mL 2.2031 mL 5.5078 mL
10 mM 0.1102 mL 0.5508 mL 1.1016 mL 2.7539 mL
15 mM 0.0734 mL 0.3672 mL 0.7344 mL 1.8359 mL
20 mM 0.0551 mL 0.2754 mL 0.5508 mL 1.3770 mL
25 mM 0.0441 mL 0.2203 mL 0.4406 mL 1.1016 mL
30 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.9180 mL
40 mM 0.0275 mL 0.1377 mL 0.2754 mL 0.6885 mL
50 mM 0.0220 mL 0.1102 mL 0.2203 mL 0.5508 mL
60 mM 0.0184 mL 0.0918 mL 0.1836 mL 0.4590 mL
80 mM 0.0138 mL 0.0688 mL 0.1377 mL 0.3442 mL
100 mM 0.0110 mL 0.0551 mL 0.1102 mL 0.2754 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

INY-03-041 trihydrochloridePROTACsAktPKBProtein kinase BCRBNMDA-MB-468HCC1937 cellsZR-75-1 cellsPC3 cellsInhibitorinhibitorinhibit

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目录号：
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