Mef2c - myocyte enhancer factor 2C Gene

种属: Mus musculus

同用名: Mef2; 5430401D19Rik; 9930028G15Rik

基因 ID: 17260 | 基因类型: protein coding

关于 Mef2c

功能概要

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and histone deacetylase binding activity. Involved in several processes, including animal organ development; modulation of chemical synaptic transmission; and positive regulation of cell differentiation. Acts upstream of or within several processes, including animal organ development; cardiac muscle hypertrophy in response to stress; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; heart; limb; and urinary system. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 20. Orthologous to human MEF2C (myocyte enhancer factor 2C). [provided by Alliance of Genome Resources, Apr 2022]

Mef2c 基因产物(18)

mRNA	Protein	Name
NM_001170537.2	NP_001164008.1	myocyte-specific enhancer factor 2C isoform 1
NM_001347564.2	NP_001334493.1	myocyte-specific enhancer factor 2C isoform 3
NM_001347566.2	NP_001334495.1	myocyte-specific enhancer factor 2C isoform 3
NM_001347567.2	NP_001334496.1	myocyte-specific enhancer factor 2C isoform 3
NM_001347568.2	NP_001334497.1	myocyte-specific enhancer factor 2C isoform 4
NM_001347569.2	NP_001334498.1	myocyte-specific enhancer factor 2C isoform 4
NM_001347571.2	NP_001334500.1	myocyte-specific enhancer factor 2C isoform 5
NM_001347572.2	NP_001334501.1	myocyte-specific enhancer factor 2C isoform 5
NM_001347573.2	NP_001334502.1	myocyte-specific enhancer factor 2C isoform 5
NM_001347574.2	NP_001334503.1	myocyte-specific enhancer factor 2C isoform 5
NM_001347575.2	NP_001334504.1	myocyte-specific enhancer factor 2C isoform 5
NM_001347576.2	NP_001334505.1	myocyte-specific enhancer factor 2C isoform 5
NM_001347577.2	NP_001334506.1	myocyte-specific enhancer factor 2C isoform 5
NM_001347578.2	NP_001334507.1	myocyte-specific enhancer factor 2C isoform 6
NM_001347579.2	NP_001334508.1	myocyte-specific enhancer factor 2C isoform 7
NM_001347580.2	NP_001334509.1	myocyte-specific enhancer factor 2C isoform 7
NM_001347581.2	NP_001334510.1	myocyte-specific enhancer factor 2C isoform 8
NM_025282.4	NP_079558.1	myocyte-specific enhancer factor 2C isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	14762206	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	7760790	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: 通过突变表型推断	20181743	MGI
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	12130539	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	17420000	MGI
enables HMG box domain binding	IPI IPI: 通过物理相互作用推断	11554755	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	7760790	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	15890826	MGI
enables chromatin binding	IDA IDA: 通过直接分析推断	18086704	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	16140986	MGI
enables histone deacetylase binding	IPI IPI: 通过物理相互作用推断	10983972	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	12130539	MGI
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	17336904	MGI
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	8035824	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of negative effect AMPA selective glutamate receptor signaling pathway	IMP IMP: 通过突变表型推断	18599438	MGI
involved in B cell homeostasis	IMP IMP: 通过突变表型推断	19211936	MGI
involved in B cell proliferation	IMP IMP: 通过突变表型推断	18438409	MGI
involved in B cell receptor signaling pathway	IMP IMP: 通过突变表型推断	18955699	MGI
involved in MAPK cascade	IDA IDA: 通过直接分析推断	14515274	MGI
involved in MAPK cascade	IMP IMP: 通过突变表型推断	18955699	MGI
acts upstream of negative effect NMDA selective glutamate receptor signaling pathway	IMP IMP: 通过突变表型推断	18599438	MGI
involved in axon guidance	IMP IMP: 通过突变表型推断	30735130	MGI
acts upstream of or within blood vessel development	IMP IMP: 通过突变表型推断	9778514	MGI
acts upstream of or within blood vessel remodeling	IMP IMP: 通过突变表型推断	9162005	MGI
acts upstream of or within cardiac muscle cell differentiation	IGI IGI: 通过遗传相互作用推断	19035347	MGI
acts upstream of or within cardiac muscle hypertrophy in response to stress	IMP IMP: 通过突变表型推断	10531040	MGI
acts upstream of or within cardiac ventricle formation	IGI IGI: 通过遗传相互作用推断	19035347	MGI
involved in cardiac ventricle formation	IMP IMP: 通过突变表型推断	16680724	MGI
acts upstream of or within cartilage morphogenesis	IMP IMP: 通过突变表型推断	17420000	MGI
acts upstream of or within cell fate commitment	IMP IMP: 通过突变表型推断	19169261	MGI
involved in cell morphogenesis involved in neuron differentiation	IMP IMP: 通过突变表型推断	18599437	MGI
acts upstream of cell proliferation in bone marrow	IGI IGI: 通过遗传相互作用推断	18278031	MGI
involved in cellular response to calcium ion	IDA IDA: 通过直接分析推断	15998798	MGI
involved in cellular response to fluid shear stress	IDA IDA: 通过直接分析推断	20181743	MGI
involved in cellular response to lipopolysaccharide	IDA IDA: 通过直接分析推断	18955699	MGI
involved in cellular response to trichostatin A	IDA IDA: 通过直接分析推断	20181743	MGI
involved in cellular response to xenobiotic stimulus	IDA IDA: 通过直接分析推断	16775627	MGI
acts upstream of or within chondrocyte differentiation	IGI IGI: 通过遗传相互作用推断	17336904	MGI
involved in embryonic heart tube development	IGI IGI: 通过遗传相互作用推断	30735130	MGI
involved in embryonic heart tube development	IMP IMP: 通过突变表型推断	30735130	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IMP IMP: 通过突变表型推断	17420000	MGI
acts upstream of or within embryonic viscerocranium morphogenesis	IMP IMP: 通过突变表型推断	17420000	MGI
acts upstream of or within endochondral ossification	IGI IGI: 通过遗传相互作用推断	17336904	MGI
acts upstream of or within endochondral ossification	IMP IMP: 通过突变表型推断	17336904	MGI
involved in epithelial cell proliferation involved in renal tubule morphogenesis	IMP IMP: 通过突变表型推断	20181743	MGI
involved in excitatory postsynaptic potential	IMP IMP: 通过突变表型推断	18599437	MGI
involved in gene expression	IMP IMP: 通过突变表型推断	30735130	MGI
involved in germinal center formation	IMP IMP: 通过突变表型推断	18955699	MGI
involved in glomerulus morphogenesis	IMP IMP: 通过突变表型推断	20181743	MGI
acts upstream of or within heart development	IMP IMP: 通过突变表型推断	9778514	MGI
involved in heart looping	IMP IMP: 通过突变表型推断	16680724	MGI
involved in humoral immune response	IMP IMP: 通过突变表型推断	18955699	MGI
involved in learning or memory	IMP IMP: 通过突变表型推断	18599437	MGI
involved in melanocyte differentiation	IMP IMP: 通过突变表型推断	21610032	MGI
acts upstream of or within monocyte differentiation	IMP IMP: 通过突变表型推断	18326819	MGI
acts upstream of or within muscle cell fate determination	IMP IMP: 通过突变表型推断	17786239	MGI
involved in negative regulation of epithelial cell proliferation	IMP IMP: 通过突变表型推断	20181743	MGI
involved in negative regulation of gene expression	IMP IMP: 通过突变表型推断	16680724	MGI
involved in negative regulation of neuron apoptotic process	IDA IDA: 通过直接分析推断	18579729	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	7677753	MGI
involved in nephron tubule epithelial cell differentiation	IMP IMP: 通过突变表型推断	20181743	MGI
involved in neural crest cell differentiation	IMP IMP: 通过突变表型推断	21610032	MGI
involved in neuron development	IMP IMP: 通过突变表型推断	18599437	MGI
involved in neuron differentiation	IMP IMP: 通过突变表型推断	18599437	MGI
involved in neuron migration	IMP IMP: 通过突变表型推断	18599437	MGI
involved in osteoblast differentiation	IEP IEP: 通过表达模式推断	21652706	MGI
acts upstream of or within osteoblast differentiation	IGI IGI: 通过遗传相互作用推断	17336904	MGI
acts upstream of or within outflow tract morphogenesis	IGI IGI: 通过遗传相互作用推断	19035347	MGI
involved in platelet formation	IMP IMP: 通过突变表型推断	19211936	MGI
involved in positive regulation of B cell proliferation	IMP IMP: 通过突变表型推断	18955699	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	9738004	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	11554755	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	9162005	MGI
involved in positive regulation of alkaline phosphatase activity	IMP IMP: 通过突变表型推断	21652706	MGI
involved in positive regulation of behavioral fear response	IMP IMP: 通过突变表型推断	18579729	MGI
involved in positive regulation of bone mineralization	IMP IMP: 通过突变表型推断	21652706	MGI
involved in positive regulation of cardiac muscle cell differentiation	IMP IMP: 通过突变表型推断	16680724	MGI
involved in positive regulation of cardiac muscle cell proliferation	IMP IMP: 通过突变表型推断	16680724	MGI
acts upstream of or within positive regulation of cell proliferation in bone marrow	IGI IGI: 通过遗传相互作用推断	18278031	MGI
involved in positive regulation of gene expression	IDA IDA: 通过直接分析推断	18579729	MGI
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	16680724	MGI
involved in positive regulation of macrophage apoptotic process	IMP IMP: 通过突变表型推断	16775627	MGI
involved in positive regulation of neuron differentiation	IDA IDA: 通过直接分析推断	18579729	MGI
involved in positive regulation of osteoblast differentiation	IMP IMP: 通过突变表型推断	21652706	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	16818234	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	7760790	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	8900141	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	15890826	MGI
involved in primary heart field specification	IMP IMP: 通过突变表型推断	16680724	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	12130539	MGI
involved in regulation of dendritic spine development	IMP IMP: 通过突变表型推断	18599438	MGI
involved in regulation of germinal center formation	IMP IMP: 通过突变表型推断	18438409	MGI
involved in regulation of megakaryocyte differentiation	IMP IMP: 通过突变表型推断	19211936	MGI
involved in regulation of neuron apoptotic process	IMP IMP: 通过突变表型推断	22496871	MGI
involved in regulation of neurotransmitter secretion	IMP IMP: 通过突变表型推断	18599438	MGI
acts upstream of or within regulation of sarcomere organization	IMP IMP: 通过突变表型推断	17875930	MGI
involved in regulation of synapse assembly	IMP IMP: 通过突变表型推断	18599438	MGI
involved in regulation of synaptic activity	IMP IMP: 通过突变表型推断	18599437	MGI
involved in regulation of synaptic plasticity	IMP IMP: 通过突变表型推断	22496871	MGI
involved in regulation of synaptic transmission, glutamatergic	IMP IMP: 通过突变表型推断	18599438	MGI
involved in renal tubule morphogenesis	IMP IMP: 通过突变表型推断	20181743	MGI
acts upstream of or within roof of mouth development	IGI IGI: 通过遗传相互作用推断	17420000	MGI
involved in secondary heart field specification	IMP IMP: 通过突变表型推断	15890826	MGI
involved in semaphorin-plexin signaling pathway involved in axon guidance	IMP IMP: 通过突变表型推断	30735130	MGI
involved in sinoatrial valve morphogenesis	IMP IMP: 通过突变表型推断	16680724	MGI
acts upstream of or within skeletal muscle cell differentiation	IMP IMP: 通过突变表型推断	22147266	MGI
acts upstream of or within skeletal muscle tissue development	IMP IMP: 通过突变表型推断	17786239	MGI
acts upstream of or within smooth muscle cell differentiation	IMP IMP: 通过突变表型推断	9778514	MGI
involved in sympathetic neuron axon guidance	IMP IMP: 通过突变表型推断	30735130	MGI
involved in ventricular cardiac muscle cell differentiation	IMP IMP: 通过突变表型推断	16680724	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	11081517	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

myocyte-specific enhancer factor 2C

Mef2c 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	Mef2c	Q8CFN5	HDAC7	Homo sapiens	Q8WUI4	Anti Bait CoIP	23565059
种属内	Mef2c	Q8CFN5	Hipk2	Mus musculus	Q9QZR5	Anti Bait CoIP	23565059

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-120877	MRT199665		99.74%	否
HY-120877A	(R)-MRT199665		98.70%	否
HY-RS08311	MEF2C Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Mef2c	NCBI	NCBI:4208

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Mef2c - myocyte enhancer factor 2C Gene

关于 Mef2c

功能概要

Mef2c 基因产物(18)

Mef2c 蛋白互作信息

直系同源

热门区域

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Mef2c - myocyte enhancer factor 2C Gene

关于 Mef2c

功能概要

Mef2c 基因产物(18)

Mef2c 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z