Hipk2 - homeodomain interacting protein kinase 2 Gene

种属: Mus musculus

同用名: Stank; 1110014O20Rik; B230339E18Rik

基因 ID: 15258 | 基因类型: protein coding

关于 Hipk2

功能概要

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; protein serine/threonine kinase activity; and transcription corepressor activity. Contributes to transcription coactivator activity. Involved in several processes, including camera-type eye morphogenesis; protein phosphorylation; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including adult walking behavior; cell surface receptor signaling pathway; and intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; metanephros; paraxial mesenchyme; and sensory organ. Orthologous to human HIPK2 (homeodomain interacting protein kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Hipk2 基因产物(4)

mRNA	Protein	Name
NM_001136065.2	NP_001129537.1	homeodomain-interacting protein kinase 2 isoform 1
NM_001294143.1	NP_001281072.1	homeodomain-interacting protein kinase 2 isoform 3
NM_001294144.1	NP_001281073.1	homeodomain-interacting protein kinase 2 isoform 4
NM_010433.2	NP_034563.2	homeodomain-interacting protein kinase 2 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
NOT enables DNA binding	IDA IDA: 通过直接分析推断	9748262	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	16407227	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	9748262	MGI
enables protein kinase activity	IDA IDA: 通过直接分析推断	9748262	MGI
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	16407227	MGI
contributes to transcription coactivator activity	IMP IMP: 通过突变表型推断	16407227	MGI
enables transcription corepressor activity	IDA IDA: 通过直接分析推断	9748262	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within adult locomotory behavior	IMP IMP: 通过突变表型推断	17159989	MGI
acts upstream of or within adult walking behavior	IMP IMP: 通过突变表型推断	17159989	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: 通过遗传相互作用推断	16537918	MGI
acts upstream of cell population proliferation	IGI IGI: 通过遗传相互作用推断	16537918	MGI
involved in embryonic camera-type eye morphogenesis	IMP IMP: 通过突变表型推断	20579985	MGI
involved in embryonic retina morphogenesis in camera-type eye	IMP IMP: 通过突变表型推断	20579985	MGI
acts upstream of or within gene expression	IGI IGI: 通过遗传相互作用推断	31582725	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI IGI: 通过遗传相互作用推断	16537918	MGI
involved in iris morphogenesis	IMP IMP: 通过突变表型推断	20579985	MGI
involved in lens induction in camera-type eye	IMP IMP: 通过突变表型推断	20579985	MGI
acts upstream of or within lung morphogenesis	IGI IGI: 通过遗传相互作用推断	31582725	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: 通过突变表型推断	17159989	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	9748262	MGI
acts upstream of neuron apoptotic process	IMP IMP: 通过突变表型推断	17159989	MGI
involved in neuron differentiation	IMP IMP: 通过突变表型推断	20579985	MGI
involved in peptidyl-serine phosphorylation	IDA IDA: 通过直接分析推断	16407227	MGI
involved in peptidyl-threonine phosphorylation	IDA IDA: 通过直接分析推断	16407227	MGI
involved in positive regulation of DNA binding	IDA IDA: 通过直接分析推断	9748262	MGI
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	16407227	MGI
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: 通过遗传相互作用推断	16537918	MGI
involved in positive regulation of protein binding	IDA IDA: 通过直接分析推断	16407227	MGI
acts upstream of or within positive regulation of protein phosphorylation	IGI IGI: 通过遗传相互作用推断	20360400	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	17159989	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	16407227	MGI
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	9748262	MGI
acts upstream of protein phosphorylation	IGI IGI: 通过遗传相互作用推断	20360400	MGI
acts upstream of or within respiratory system process	IGI IGI: 通过遗传相互作用推断	31582725	MGI
involved in retina layer formation	IMP IMP: 通过突变表型推断	20579985	MGI
acts upstream of or within smoothened signaling pathway	IGI IGI: 通过遗传相互作用推断	16537918	MGI
acts upstream of or within thyroid gland development	IGI IGI: 通过遗传相互作用推断	31582725	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IMP IMP: 通过突变表型推断	17159989	MGI
acts upstream of or within voluntary musculoskeletal movement	IMP IMP: 通过突变表型推断	17159989	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of RNA polymerase II transcription regulator complex	IMP IMP: 通过突变表型推断	16407227	MGI
located in cytoplasm	IDA IDA: 通过直接分析推断	11078605	MGI
located in nucleus	IDA IDA: 通过直接分析推断	9748262	MGI
part of protein-containing complex	IDA IDA: 通过直接分析推断	16870469	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

homeodomain-interacting protein kinase 2

nuclear body-associated kinase 1

sialophorin tail-associated nuclear serine/threonine-protein kinase

Hipk2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	Hipk2	Q9QZR5	WSB1	Homo sapiens	Q9Y6I7	Pull Down	18093972
种属间	Hipk2	Q9QZR5	MECP2	Homo sapiens	P51608	Anti Bait CoIP	19820693
种属内	Hipk2	Q9QZR5	Nlk	Mus musculus	O54949	Y2H	15082531
种属内	Hipk2	Q9QZR5	Myb	Mus musculus	P06876	Y2H	15082531
种属内	Hipk2	Q9QZR5	Mef2c	Mus musculus	Q8CFN5	Anti Bait CoIP	23565059

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-100464	tBID	Inhibitor	99.03%	否
HY-U00439A	Protein kinase inhibitor 1 hydrochloride	Inhibitor	≥98.0%	否
HY-135906	CK2/ERK8-IN-1		≥99.0%	否
HY-128439	BT173	Inhibitor	98.71%	否
HY-U00439	Protein kinase inhibitor 1	Inhibitor	≥99.0%	否
HY-RS06182	HIPK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Hipk2	NCBI	NCBI:28996

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Hipk2 - homeodomain interacting protein kinase 2 Gene

关于 Hipk2

功能概要

Hipk2 基因产物(4)

Hipk2 蛋白互作信息

直系同源

热门区域

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Hipk2 - homeodomain interacting protein kinase 2 Gene

关于 Hipk2

功能概要

Hipk2 基因产物(4)

Hipk2 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z