2. Gene
  3. Mmp7 - matrix metallopeptidase 7 Gene

Mmp7 - matrix metallopeptidase 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：基质金属肽酶 7

种属: Mus musculus

同用名: MAT; MMP-7

基因 ID: 17393 | 基因类型: protein coding

关于 Mmp7

Chromosome 9: 7,692,091-7,699,586 forward strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 163 orthologues, 23 paralogues and is associated with 18 phenotypes. Biased expression in large intestine adult (RPKM 146.), small intestine adult (RPKM 25.5) and 2 other tissues.

功能概要

该基因编码细胞外基质降解酶基质金属蛋白酶家族的一个成员，这些酶参与组织重塑、伤口修复、动脉粥样硬化进展和肿瘤侵袭。编码的前原蛋白经过蛋白水解加工，产生成熟的锌依赖性内肽酶。缺少编码蛋白的小鼠缺乏功能性隐蛋白。该基因位于 9 号染色体上的其他基质金属蛋白酶基因簇中。[RefSeq 提供，2016 年 2 月]

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase Enzyme. Mice lacking the encoded protein are deficient in functional cryptdins. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]

Mmp7 基因产物(2)

mRNA Protein Name
NM_010810.5 NP_034940.2 matrilysin isoform 1 preproprotein
NM_001319986.1 NP_001306915.1 matrilysin isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables peptidase activity IDA
IDA: 通过直接分析推断
20056603 MGI
enables peptidase activity IMP
IMP: 通过突变表型推断
20056603 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within antibacterial peptide biosynthetic process IMP
IMP: 通过突变表型推断
20056603 MGI
acts upstream of or within antibacterial peptide secretion IMP
IMP: 通过突变表型推断
11248802 MGI
acts upstream of or within defense response to Gram-negative bacterium IMP
IMP: 通过突变表型推断
11248802 MGI
acts upstream of or within defense response to Gram-positive bacterium IMP
IMP: 通过突变表型推断
11248802 MGI
acts upstream of or within defense response to bacterium IMP
IMP: 通过突变表型推断
11248802 MGI
acts upstream of or within proteolysis IDA
IDA: 通过直接分析推断
20056603 MGI
acts upstream of or within proteolysis IMP
IMP: 通过突变表型推断
20056603 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
9037065 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: 通过突变表型推断
11248802 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Mmp7 蛋白结构

PG_binding_1

PG_binding_1: pfam01471 (33 - 84)

Peptidase_M10

Peptidase_M10: pfam00413 (105 - 261)

  • 0
  • 100
  • 200
  • 267 a.a.
蛋白主名 其他名称

matrilysin

matrilysin, uterine

matrin

matrix metalloproteinase 7

pump-1 protease

uterine metalloproteinase

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-12169 Marimastat Inhibitor ≥98.0% Phase 3
Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13564 Batimastat Inhibitor 98.92% 否
HY-103444 ARP-100 Inhibitor ≥99.0% 否
HY-N0774 Isofraxidin Inhibitor 99.00% 否
HY-151540 MMP-7-IN-1 Inhibitor 99.68% 否
HY-131498 MOCAc-PLGL(Dpa)AR 99.86% 否
HY-156430 MMP-7-IN-3 Inhibitor 99.93% 否
HY-RS08552 Mmp7 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-153563 MMP-7-IN-2 Inhibitor 99.34% 否
HY-119423 MMP Inhibitor II Inhibitor ≥99.0% 否
HY-161169 TP0628103 Inhibitor / 否
HY-130076 MMP-2 Inhibitor II Inhibitor / 否
HY-RS08551 MMP7 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08553 Mmp7 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-13564A Batimastat sodium salt Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mmp7 NCBI NCBI:4316
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