Pak3 - p21 (RAC1) activated kinase 3 Gene

中文名称：p21 (RAC1) 激活激酶 3

种属: Mus musculus

同用名: Stk4; PAK-3; Pak65beta; Pak65alpha

关于 Pak3

功能概要

该基因编码的蛋白可启动蛋白激酶活性和小 GTPase 结合活性。参与轴突发生和树突棘形态发生。在有机环状化合物和树突棘发育的细胞反应上游或细胞反应中起作用。位于突触后密度。在谷氨酸能突触中活跃。以多种结构表达，包括中枢神经系统；性腺;肝;肺;和视网膜。用于研究非综合征性 X 连锁智力障碍 30。该基因的人类直系同源物涉及非综合征性 X 连锁智力障碍 30。与人类 PAK3（p21 (RAC1) 激活激酶 3）直系同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein kinase activity and small GTPase binding activity. Involved in axonogenesis and dendritic spine morphogenesis. Acts upstream of or within cellular response to organic cyclic compound and dendritic spine development. Located in postsynaptic density. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; gonad; liver; lung; and retina. Used to study non-syndromic X-linked intellectual disability 30. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 30. Orthologous to human PAK3 (p21 (RAC1) activated kinase 3). [provided by Alliance of Genome Resources, Apr 2022]