2. Gene
  3. Pim2 - proviral integration site 2 Gene

Pim2 - proviral integration site 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：前病毒整合位点 2

种属: Mus musculus

同用名: Pim-2; DXCch3

基因 ID: 18715 | 基因类型: protein coding

关于 Pim2

Chromosome X: 7,744,501-7,749,671 forward strand.GRCm39:CM001013.3

This gene has 3 transcripts (splice variants), 115 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in spleen adult (RPKM 19.6), thymus adult (RPKM 12.7) and 28 other tissues.

功能概要

该基因编码的蛋白可启动蛋白质丝氨酸/苏氨酸激酶活性。参与多个过程，包括 I-kappaB 激酶/NF-kappaB 信号的正调控；自噬的正调节；和蛋白质稳定。作用于几个过程的上游或内部，包括凋亡线粒体变化；蛋白质结合活性的负调节；和巨自噬的正调控。预计在细胞质中有活性。在脾脏和胸腺中表达。与人 PIM2（Pim-2 原癌基因，丝氨酸/苏氨酸激酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of autophagy; and protein stabilization. Acts upstream of or within several processes, including apoptotic mitochondrial changes; negative regulation of protein binding activity; and positive regulation of macroautophagy. Predicted to be active in cytoplasm. Is expressed in spleen and thymus. Orthologous to human PIM2 (Pim-2 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Pim2 基因产物(1)

mRNA Protein Name
NM_138606.2 NP_613072.1 serine/threonine-protein kinase pim-2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11854514 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
11854514 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
12869584 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within apoptotic mitochondrial changes IDA
IDA: 通过直接分析推断
12869584 MGI
acts upstream of apoptotic process IMP
IMP: 通过突变表型推断
17476689 MGI
acts upstream of macroautophagy IMP
IMP: 通过突变表型推断
17476689 MGI
acts upstream of or within negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
12869584 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
17476689 MGI
acts upstream of or within negative regulation of protein binding IMP
IMP: 通过突变表型推断
17476689 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
18438430 MGI
involved in positive regulation of autophagy IMP
IMP: 通过突变表型推断
17476689 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
15548703 MGI
acts upstream of or within positive regulation of macroautophagy IMP
IMP: 通过突变表型推断
17476689 MGI
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
15548703 MGI
involved in protein stabilization IDA
IDA: 通过直接分析推断
18438430 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pim2 蛋白结构

PKc_like

PKc_like: cl21453 (89 - 345)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase pim-2

相关产品

Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-101870B Uzansertib phosphate Inhibitor 99.39% Phase 2
HY-101870 Uzansertib Inhibitor / Phase 2
HY-15604 AZD1208 Inhibitor 99.71% Phase 1
HY-19322B PIM-447 dihydrochloride Inhibitor 99.94% Phase 1
Pre-clinical Phase
生物活性分子 (18)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15698A CRT0066101 dihydrochloride Inhibitor 99.92% 否
HY-16576A SMI-4a Inhibitor 99.63% 否
HY-N4149 Quercetagetin Inhibitor 99.94% 否
HY-16976 GDC-0339 Inhibitor 99.87% 否
HY-101947 SMI-16a Inhibitor ≥98.0% 否
HY-120758 SEL24-B489 Inhibitor 99.02% 否
HY-15698 CRT0066101 Inhibitor 99.66% 否
HY-111552 PIM1-IN-1 Inhibitor 99.83% 否
HY-122665 HTH-01-091 Inhibitor 98.64% 否
HY-164460 AZD1897 Inhibitor 99.69% 否
HY-163119 Pim-1 kinase inhibitor 9 Inhibitor / 否
HY-163442A PIM3-IN-1 hydrochloride Inhibitor / 否
HY-15698B CRT0066101 trihydrochloride Inhibitor / 否
HY-142696 CDK6/PIM1-IN-1 Inhibitor / 否
HY-160006 PIM-IN-2 / 否
HY-123983 HS56 Inhibitor / 否
HY-157404 Pim-1/2 kinase inhibitor 2 Inhibitor / 否
HY-101783 GNE-955 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pim2 NCBI NCBI:11040
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