2. Gene
  3. Plk1 - polo like kinase 1 Gene

Plk1 - polo like kinase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：马球样激酶 1

种属: Mus musculus

同用名: Plk; STPK13

基因 ID: 18817 | 基因类型: protein coding

关于 Plk1

Chromosome 7: 121,758,662-121,769,096 forward strand.GRCm39:CM001000.3

This gene has 3 transcripts (splice variants), 186 orthologues, 4 paralogues and is associated with 16 phenotypes. Broad expression in liver E14.5 (RPKM 39.9), liver E14 (RPKM 38.7) and 17 other tissues.

功能概要

该基因编码的Ser/Thr蛋白激酶属于CDC5/Polo亚家族。它在有丝分裂期间高表达，并可能在 S 期的 DNA 复制中发挥作用。该基因在所有胚胎组织中均有表达，但在成人组织中仅限于胸腺和卵巢。纯合基因敲除小鼠的胚胎是致命的，表明该基因对早期胚胎发育很重要。该基因被认为是潜在的致癌基因，因为它在多种肿瘤和肿瘤细胞系中过度表达。癌细胞中这种蛋白质的消耗已被证明可以抑制细胞增殖并抑制致癌转化；因此，它是癌症治疗的目标。 [RefSeq 提供，2015 年 9 月]

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and may play a role in DNA replication during S phase. This gene is expressed in all embryonic tissues, but restricted to thymus and ovaries in adult tissues. Homozygous knockout mice were embryonic lethal, suggesting that this gene is important for early embryonic development. This gene is thought to be a potential oncogene because it is overexpressed in a variety of tumors and tumor cell lines. Depletion of this protein in Cancer cells has been shown to inhibit cell proliferation and suppress oncogenic transformation; hence, it is a target for Cancer therapy. [provided by RefSeq, Sep 2015]

Plk1 基因产物(1)

mRNA Protein Name
NM_011121.4 NP_035251.3 serine/threonine-protein kinase PLK1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22405274 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
21637952 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
22405274 MGI
enables protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
27979967 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within female meiosis chromosome segregation IMP
IMP: 通过突变表型推断
25533956 MGI
acts upstream of or within homologous chromosome segregation IMP
IMP: 通过突变表型推断
25533956 MGI
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
27979967 MGI
acts upstream of or within peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
27979967 MGI
acts upstream of or within protein localization to organelle IDA
IDA: 通过直接分析推断
27979967 MGI
acts upstream of or within protein phosphorylation IMP
IMP: 通过突变表型推断
22854038 MGI
involved in protein phosphorylation IMP
IMP: 通过突变表型推断
21637952 MGI
acts upstream of or within regulation of protein binding IMP
IMP: 通过突变表型推断
27979967 MGI
acts upstream of or within synaptonemal complex disassembly IMP
IMP: 通过突变表型推断
22854038 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centriolar satellite IDA
IDA: 通过直接分析推断
27979967 MGI
located in centriole IDA
IDA: 通过直接分析推断
27979967 MGI
located in chromatin IDA
IDA: 通过直接分析推断
22854038 MGI
located in chromosome, centromeric region IDA
IDA: 通过直接分析推断
26919979 MGI
located in condensed chromosome, centromeric region IDA
IDA: 通过直接分析推断
22854038 MGI
located in kinetochore IDA
IDA: 通过直接分析推断
25533956 MGI
located in mitotic spindle pole IDA
IDA: 通过直接分析推断
26919979 MGI
located in synaptonemal complex IDA
IDA: 通过直接分析推断
22854038 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Plk1 蛋白结构

STKc_PLK1

STKc_PLK1: cd14187 (44 - 308)

POLO_box_1

POLO_box_1: cd13118 (406 - 493)

POLO_box_2

POLO_box_2: cd13117 (508 - 589)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 603 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase PLK1

PLK-1

serine/threonine-protein kinase 13

重组 Plk1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73706 PLK1 Protein, Mouse (sf9, His) Q07832 (M1-S603) ≥95%

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-12137 Volasertib Inhibitor 99.87% 是
HY-12137A Volasertib trihydrochloride Inhibitor / 否
Clinical Phase
生物活性分子 (10)
目录号 产品名 作用方式
纯度 Phase
HY-12037A Rigosertib Inhibitor 99.01% Phase 3
HY-12037 Rigosertib sodium Inhibitor 99.57% Phase 3
HY-50698 BI 2536 Inhibitor 99.95% Phase 2
HY-15828 Onvansertib Inhibitor 99.55% Phase 2
HY-147298 Plogosertib Inhibitor 99.95% Phase 2
HY-50877 GSK461364 Inhibitor 99.82% Phase 1
HY-15160 TAK-960 Inhibitor 99.75% Phase 1
HY-12045 HMN-214 Inhibitor 99.16% Phase 1
HY-15160B TAK-960 dihydrochloride Inhibitor 99.19% Phase 1
HY-15160A TAK-960 hydrochloride Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (23)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100789 ON1231320 Inhibitor 99.24% 否
HY-11003 GW843682X Inhibitor 99.89% 否
HY-15155 MLN0905 Inhibitor 99.94% 否
HY-15161 Ro3280 Inhibitor 98.87% 否
HY-18009 (Z)-LFM-A13 Inhibitor 99.80% 否
HY-108597 TC-S 7005 Inhibitor 99.68% 否
HY-15158 SBE13 Hydrochloride Inhibitor 99.66% 否
HY-12134 Poloxin Inhibitor 98.01% 否
HY-N8692 Dihydrobaicalein Inhibitor 99.94% 否
HY-158031 PLK1/BRD4-IN-5 Inhibitor 99.55% 否
HY-15159 Cyclapolin 9 Inhibitor 99.16% 否
HY-160558 PLK1/BRD4-IN-3 Inhibitor 99.66% 否
HY-77195 Poloxime Inhibitor ≥95.0% 否
HY-110002 LFM-A13 Inhibitor 99.65% 否
HY-15158A SBE13 Inhibitor / 否
HY-143471 WNY0824 Inhibitor / 否
HY-112395 BTO-1 Inhibitor / 否
HY-169579 PLK1-IN-11 Inhibitor / 否
HY-149100 PLK1-IN-6 Inhibitor / 否
HY-161521 PLK1-IN-10 Inhibitor / 否
HY-18651 (E/Z)-Rigosertib sodium / 否
HY-148974 PLK1-IN-5 Inhibitor / 否
HY-115589 YLT-11 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Plk1 NCBI NCBI:5347
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