1. Gene
  2. PLK1 - polo like kinase 1 Gene

PLK1 - polo like kinase 1 Gene

中文名称:马球样激酶 1

种属: Homo sapiens

同用名: PLK; STPK13

基因 ID: 5347 | 基因类型: protein coding

关于 PLK1

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:23,678,889-23,690,367 (from NCBI)

This gene has 9 transcripts (splice variants), 184 orthologues and 4 paralogues. Biased expression in testis (RPKM 20.5), lymph node (RPKM 15.8) and 13 other tissues.

功能概要

该基因编码的 Ser/Thr 蛋白激酶属于 CDC5/Polo 亚家族。它在有丝分裂期间高度表达,并且在许多不同类型的癌症中发现水平升高。癌细胞中这种蛋白质的消耗会显着抑制细胞增殖并诱导细胞凋亡;因此,它是癌症治疗的目标。[RefSeq 提供,2015 年 9 月]

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of Cancer. Depletion of this protein in Cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for Cancer therapy. [provided by RefSeq, Sep 2015]

PLK1 基因产物(1)

mRNA Protein Name
NM_005030.6 NP_005021.2 serine/threonine-protein kinase PLK1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IMP
IMP: 通过突变表型推断
17461553 GOA
enables anaphase-promoting complex binding IPI
IPI: 通过物理相互作用推断
18662541 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
21041660 GOA
enables magnesium ion binding IMP
IMP: 通过突变表型推断
17461553 GOA
enables microtubule binding IDA
IDA: 通过直接分析推断
12939256 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12493754 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
17146433 GOA
enables protein kinase activity IMP
IMP: 通过突变表型推断
17461553 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
12639966 GOA
enables protein serine kinase activity IDA
IDA: 通过直接分析推断
21723128 GOA
enables protein serine/threonine kinase activity EXP
EXP: 通过实验结果推断
18378770 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
12524548 GOA
enables protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
19473992 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G2/M transition of mitotic cell cycle IDA
IDA: 通过直接分析推断
19160488 GOA
involved in centrosome cycle IMP
IMP: 通过突变表型推断
8991084 GOA
involved in double-strand break repair IDA
IDA: 通过直接分析推断
22325354 GOA
involved in double-strand break repair via alternative nonhomologous end joining IDA
IDA: 通过直接分析推断
37440612 GOA
involved in establishment of mitotic spindle orientation IDA
IDA: 通过直接分析推断
23509069 GOA
acts upstream of or within establishment of protein localization IMP
IMP: 通过突变表型推断
18331714 GOA
involved in microtubule bundle formation IDA
IDA: 通过直接分析推断
12939256 GOA
involved in mitotic G2 DNA damage checkpoint signaling IDA
IDA: 通过直接分析推断
18662541 GOA
involved in mitotic cell cycle IDA
IDA: 通过直接分析推断
18615013 GOA
involved in mitotic cell cycle IMP
IMP: 通过突变表型推断
18477460 GOA
involved in mitotic cytokinesis IDA
IDA: 通过直接分析推断
19468302 GOA
involved in mitotic sister chromatid segregation IMP
IMP: 通过突变表型推断
23455478 GOA
involved in mitotic spindle assembly checkpoint signaling IMP
IMP: 通过突变表型推断
23455478 GOA
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
18174154 GOA
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
21041660 GOA
involved in negative regulation of double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
28512243 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
18174154 GOA
involved in nuclear membrane disassembly IMP
IMP: 通过突变表型推断
20679239 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
16885022 GOA
involved in positive regulation of peptidyl-threonine phosphorylation IMP
IMP: 通过突变表型推断
21041660 GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
19473992 GOA
involved in positive regulation of proteolysis IDA
IDA: 通过直接分析推断
16885022 GOA
involved in positive regulation of ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
15148369 GOA
involved in positive regulation of ubiquitin-protein transferase activity IMP
IMP: 通过突变表型推断
19473992 GOA
involved in protein destabilization IDA
IDA: 通过直接分析推断
16885022 GOA
involved in protein localization to chromatin IDA
IDA: 通过直接分析推断
21111234 GOA
involved in protein localization to nuclear envelope IMP
IMP: 通过突变表型推断
20679239 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
19468300 GOA
involved in protein phosphorylation IMP
IMP: 通过突变表型推断
17461553 GOA
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
16885022 GOA
involved in regulation of cytokinesis IDA
IDA: 通过直接分析推断
17351640 GOA
involved in regulation of cytokinesis IMP
IMP: 通过突变表型推断
12939256 GOA
involved in regulation of mitotic cell cycle IMP
IMP: 通过突变表型推断
17495026 GOA
involved in regulation of mitotic metaphase/anaphase transition IDA
IDA: 通过直接分析推断
23509069 GOA
involved in regulation of mitotic metaphase/anaphase transition IMP
IMP: 通过突变表型推断
21041660 GOA
involved in regulation of mitotic spindle assembly IDA
IDA: 通过直接分析推断
22621898 GOA
involved in regulation of protein binding IMP
IMP: 通过突变表型推断
21041660 GOA
involved in regulation of protein localization to cell cortex IDA
IDA: 通过直接分析推断
23509069 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
8991084 GOA
located in kinetochore IDA
IDA: 通过直接分析推断
17617734 GOA
located in microtubule cytoskeleton IDA
IDA: 通过直接分析推断
21041660 GOA
located in midbody IDA
IDA: 通过直接分析推断
19468300 GOA
located in nucleus IDA
IDA: 通过直接分析推断
18615013 GOA
part of outer kinetochore IDA
IDA: 通过直接分析推断
18195732 GOA
located in spindle IDA
IDA: 通过直接分析推断
12939256 GOA
colocalizes with spindle microtubule IDA
IDA: 通过直接分析推断
21041660 GOA
located in spindle midzone IDA
IDA: 通过直接分析推断
19468302 GOA
located in spindle pole IDA
IDA: 通过直接分析推断
18331714 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PLK1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (55 - 305)

POLO_box

POLO_box: POLO box duplicated region (417 - 480)

POLO_box

POLO_box: POLO box duplicated region (515 - 583)

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  • 500
  • 603 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase PLK1

PLK-1

cell cycle regulated protein kinase

polo (Drosophia)-like kinase

serine/threonine-protein kinase 13

PLK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PLK1 P53350 ERCC6L Homo sapiens Q2NKX8 35271311
种属内
PLK1 P53350 ERCC6L Homo sapiens Q2NKX8
TAP
20360068
种属内
PLK1 P53350 NEK9 Homo sapiens Q8TD19 21642957
种属内
PLK1 P53350 NEK9 Homo sapiens Q8TD19 21642957
种属内
PLK1 P53350 NEK9 Homo sapiens Q8TD19 21642957
种属内
PLK1 P53350 C1orf226 Homo sapiens A1L170 32707033
种属内
PLK1 P53350 PSEN1 Homo sapiens P49768-2 32814053
种属内
PLK1 P53350 PSEN1 Homo sapiens P49768-2 32814053
种属内
PLK1 P53350 PSEN1 Homo sapiens P49768-2 32814053
种属内
PLK1 P53350 CHEK2 Homo sapiens O96017
IF
12493754
种属内
PLK1 P53350 CHEK2 Homo sapiens O96017 20126263
种属内
PLK1 P53350 CHEK2 Homo sapiens O96017 12493754
种属内
PLK1 P53350 CHEK2 Homo sapiens O96017 12493754
种属内
PLK1 P53350 CHEK2 Homo sapiens O96017 12493754
种属间
PLK1 P53350 Tp53bp1 Mus musculus P70399-1 20126263
种属内
PLK1 P53350 CENPU Homo sapiens Q71F23-1 19597481
种属内
PLK1 P53350 CENPU Homo sapiens Q71F23-1
ITC
19597481
种属内
PLK1 P53350 CENPU Homo sapiens Q71F23-1 19597481
种属内
PLK1 P53350 BIRC6 Homo sapiens Q9NR09 26496610
种属内
PLK1 P53350 BIRC6 Homo sapiens Q9NR09 18329369
种属内
PLK1 P53350 SLX4 Homo sapiens Q8IY92 32707033
种属内
PLK1 P53350 SLX4 Homo sapiens Q8IY92
Y2H
19596235
种属内
PLK1 P53350 SLX4 Homo sapiens Q8IY92 25852190
种属内
PLK1 P53350 SLX4 Homo sapiens Q8IY92 19596235
种属内
PLK1 P53350 GTSE1 Homo sapiens Q9NYZ3 20577264
种属内
PLK1 P53350 GTSE1 Homo sapiens Q9NYZ3
IF
20577264
种属内
PLK1 P53350 NHSL2 Homo sapiens Q5HYW2 32296183
种属内
PLK1 P53350 MCM7 Homo sapiens P33993 15654075
种属内
PLK1 P53350 TANK Homo sapiens Q92844 21988832
种属内
PLK1 P53350 TANK Homo sapiens Q92844 21988832
种属内
PLK1 P53350 YWHAE Homo sapiens P62258 36931259
种属内
PLK1 P53350 TP53 Homo sapiens P04637
Y2H
16753148
种属内
PLK1 P53350 MCM2 Homo sapiens P49736
TAP
27173435
种属内
PLK1 P53350 MDM2 Homo sapiens Q00987 19833129
种属内
PLK1 P53350 MDM2 Homo sapiens Q00987 19833129
种属内
PLK1 P53350 MDM2 Homo sapiens Q00987 19833129
种属内
PLK1 P53350 TP53BP1 Homo sapiens Q12888 20126263
种属内
PLK1 P53350 TP53BP1 Homo sapiens Q12888 32707033
种属内
PLK1 P53350 AXIN2 Homo sapiens Q9Y2T1 16815967
种属内
PLK1 P53350 AURKA Homo sapiens O14965 18615013
种属内
PLK1 P53350 KAT7 Homo sapiens O95251
Y2H
18250300
种属内
PLK1 P53350 KAT7 Homo sapiens O95251 18250300
种属内
PLK1 P53350 KAT7 Homo sapiens O95251 18250300
种属内
PLK1 P53350 KAT7 Homo sapiens O95251 18250300
种属内
PLK1 P53350 KAT7 Homo sapiens O95251 18250300
种属内
PLK1 P53350 SPAG9 Homo sapiens O60271
TAP
27173435
种属内
PLK1 P53350 SPAG9 Homo sapiens O60271 19596235
种属内
PLK1 P53350 BORA Homo sapiens Q6PGQ7 35271311
种属内
PLK1 P53350 BORA Homo sapiens Q6PGQ7 18615013
种属内
PLK1 P53350 CDC25C Homo sapiens P30307 12595692
种属内
PLK1 P53350 CDC25C Homo sapiens P30307 19597481
种属内
PLK1 P53350 BORA Homo sapiens Q6PGQ7 32707033
种属内
PLK1 P53350 CDC25C Homo sapiens P30307
ITC
17307877
种属内
PLK1 P53350 CDC25C Homo sapiens P30307 19597481
种属内
PLK1 P53350 CDC25C Homo sapiens P30307 14532005
种属内
PLK1 P53350 CDC25C Homo sapiens P30307 17307877
种属内
PLK1 P53350 BORA Homo sapiens Q6PGQ7 33961781
种属内
PLK1 P53350 BORA Homo sapiens Q6PGQ7 19596235
种属内
PLK1 P53350 BORA Homo sapiens Q6PGQ7 28514442
种属内
PLK1 P53350 CDC25C Homo sapiens P30307 17307877
种属内
PLK1 P53350 FADD Homo sapiens Q13158 20890306
种属内
PLK1 P53350 FADD Homo sapiens Q13158 20890306
种属内
PLK1 P53350 HSPA1A Homo sapiens P08107 21887822
种属内
PLK1 P53350 HSPA1A Homo sapiens P08107 21887822
种属间
PLK1 P53350 Dvl2 Mus musculus Q60838 22609948
种属内
PLK1 P53350 PHC2 Homo sapiens Q8IXK0
Y2H
21988832
种属内
PLK1 P53350 OFD1 Homo sapiens O75665 21988832
种属内
PLK1 P53350 RACGAP1 Homo sapiens Q9H0H5 19468302
种属内
PLK1 P53350 RACGAP1 Homo sapiens Q9H0H5 19468302
种属内
PLK1 P53350 RACGAP1 Homo sapiens Q9H0H5 19468300
种属内
PLK1 P53350 DVL2 Homo sapiens O14641 22609948
种属内
PLK1 P53350 DVL2 Homo sapiens O14641 32707033
种属内
PLK1 P53350 CASP8 Homo sapiens Q14790 32814053
种属内
PLK1 P53350 CASP8 Homo sapiens Q14790 32814053
种属内
PLK1 P53350 CASP8 Homo sapiens Q14790 32814053
种属内
PLK1 P53350 EVI5 Homo sapiens O60447 16439210
种属内
PLK1 P53350 EVI5 Homo sapiens O60447 26496610
种属内
PLK1 P53350 EVI5 Homo sapiens O60447 16439210
种属内
PLK1 P53350 WEE1 Homo sapiens P30291 32707033
种属内
PLK1 P53350 EIF4B Homo sapiens P23588 21887822
种属内
PLK1 P53350 EIF4B Homo sapiens P23588 21887822
种属间
PLK1 P53350 Q99IB8-PRO_0000045602 Hepatitis C virus Q99IB8-PRO_0000045602 20534861
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PLK1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76550 PLK1 Protein, Human (sf9, His) P53350 (M1-S603) ≥95%

PLK1 抗体

目录号 产品名 应用 反应物种
HY-P80972 PLK1 Antibody WB, ICC/IF, IP Human, Rat

关联疾病

疾病名称 别名
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Lung Cancer Susceptibility 3

Lung Adenocarcinoma

Adenocarcinoma Of Lung

LNCR3

Adenocarcinoma Of Lung, Susceptibility To

Bronchogenic Lung Adenocarcinoma

Nonsmall Cell Adenocarcinoma

Adenocarcinoma Lung

Lung Adenocarcinomas

Non-Small Cell Adenocarcinoma

Breast Intraductal Papillomatosis

Breast Papillomatosis

Intraductal Papillomatosis Of The Breast

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Polyploidy

Polyploid

Polyploidy Syndrome

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome

Mva Syndrome

Mosaic Variegated Aneuplody Microcephaly Syndrome

Warburton Anyane Yeboa Syndrome

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly

Gastric Cancer

Stomach Cancer

Stomach Carcinoma

Gastric Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia

Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Desmoplastic/Nodular Medulloblastoma

Medulloblastoma With Extensive Nodularity

Desmoplastic Medulloblastoma

Medulloblastoma, Somatic

Medulloblastoma, Desmoplastic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Mben

Medulloblastoma Desmoplastic

Neuroectodermal Tumors, Primitive

Medulloblastomas

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

Cornelia De Lange Syndrome

De Lange Syndrome

Brachmann De Lange Syndrome

Brachmann-De Lange Syndrome

Cdls

Bdls

Typus Degenerativus Amstelodamensis

Cataract 36

CTRCT36

Catc4

Autosomal Recessive Congenital Cataract 4

Cataract, Autosomal Recessive Congenital 4

Cataract, Type 36

Ataxia-Telangiectasia

Ataxia Telangiectasia

Louis-Bar Syndrome

AT

At1

Ataxia-Telangiectasia Syndrome

Ataxia - Telangiectasia Variant

Boder-Sedgwick Syndrome

Louis Bar Syndrome

Cerebello-Oculocutaneous Telangiectasia

Immunodeficiency With Ataxia Telangiectasia

A-T

Ataxia Telangiectasia Syndrome

Atm

Telangiectasia, Cerebello-Oculocutaneous

Ataxia-Telangiectasia Variant

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Gonococcal Keratitis
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia

Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus

Rhabdomyosarcoma
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus PLK1 VGNC VGNC:33033
Rattus norvegicus PLK1 RGD RGD:3352
Mus musculus PLK1 MGD MGI:97621
Canis familiaris PLK1 VGNC VGNC:44695
Felis catus PLK1 VGNC VGNC:68905
Others PLK1 NCBI