BIRC6 - baculoviral IAP repeat containing 6 Gene

中文名称：含杆状病毒 IAP 重复 6

种属: Homo sapiens

同用名: BRUCE; APOLLON

基因 ID: 57448 | 基因类型: protein coding

关于 BIRC6

Cytogenetic location: 2p22.3 Genomic coordinates (GRCh38): 2:32,357,023-32,618,878 (from NCBI)

This gene has 15 transcripts (splice variants), 205 orthologues, 7 paralogues and is associated with 115 phenotypes. Ubiquitous expression in thyroid (RPKM 6.5), ovary (RPKM 6.3) and 25 other tissues.

功能概要

该基因编码的蛋白质具有 BIR (细胞凋亡蛋白重复的杆状病毒抑制) 结构域和 UBCc (泛素结合酶 E2，催化) 结构域。该蛋白通过泛素化促进凋亡蛋白的降解来抑制细胞凋亡。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein with a BIR (baculoviral inhibition of Apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating Enzyme E2, catalytic) domain. This protein inhibits Apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]

BIRC6 基因产物(2)

mRNA	Protein	Name
NM_001378125.1	NP_001365054.1	baculoviral IAP repeat-containing protein 6 isoform 2
NM_016252.4	NP_057336.3	baculoviral IAP repeat-containing protein 6 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cysteine-type endopeptidase inhibitor activity	IMP IMP: 通过突变表型推断	15200957	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	14765125	GOA
enables ubiquitin-protein transferase activity	IDA IDA: 通过直接分析推断	15200957	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	15200957	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway	IMP IMP: 通过突变表型推断	14765125	GOA
involved in regulation of cytokinesis	IMP IMP: 通过突变表型推断	18329369	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endosome	IDA IDA: 通过直接分析推断	18329369	GOA
located in microtubule organizing center	IDA IDA: 通过直接分析推断	18329369	GOA
located in midbody	IDA IDA: 通过直接分析推断	18329369	GOA
located in spindle pole	IDA IDA: 通过直接分析推断	18329369	GOA
located in trans-Golgi network	IDA IDA: 通过直接分析推断	18329369	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BIRC6 蛋白结构

BIR

BIRC6

UQ_con

0
800
1600
2400
3200
4000
4857 a.a.

蛋白主名

其他名称

baculoviral IAP repeat-containing protein 6

BIR repeat-containing ubiquitin-conjugating enzyme

BIRC6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	BIRC6	Q9NR09	EXOC4	Homo sapiens	Q96A65	IF	18329369
种属内	BIRC6	Q9NR09	EXOC4	Homo sapiens	Q96A65	Anti Tag CoIP	18329369
种属内	BIRC6	Q9NR09	PLK1	Homo sapiens	P53350	Anti Bait CoIP	18329369
种属内	BIRC6	Q9NR09	PLK1	Homo sapiens	P53350	IF	18329369
种属内	BIRC6	Q9NR09	MAP2K1	Homo sapiens	Q02750	Anti Bait CoIP	18329369

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Brain Cancer

Adult Brain Tumor	Malignant Neoplasm Of Brain
Brain Neoplasms	Brain Neoplasm
Neoplasm Of Brain	Primary Malignant Neoplasm Of Brain
Brain Tumors	Adult Malignant Brain Neoplasm
Brain Neoplasm, Adult	Bt - Brain Tumour
Malignant Brain Tumour	Malignant Primary Brain Neoplasm
Malignant Primary Brain Tumor	Malignant Tumor Of Adult Brain
Malignant Tumor Of Brain	Primary Brain Neoplasm
Primary Brain Tumor	Tumor Of The Brain
Brain Tumor, Adult	Brain Tumor Primary
Malignant Primary Brain Tumors	Primary Brain Tumors
Cancer, Brain	Brain Tumor, Primary

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Hypoplastic Left Heart Syndrome

Hlhs	Heart, Hypoplastic Left, Syndrome
Hypoplasia Of The Left Heart	Left Heart Hypoplasia Syndrome
Hlhs - [Hypoplastic Left Heart Syndrome]	Hypoplasia Of Aortic Valve, In Hypoplastic Left Heart Syndrome
Atresia Of Mitral Valve, In Hypoplastic Left Heart Syndrome	Atresia Or Marked Hypoplasia Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle
Atresia Or Marked Hypoplasia, Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle With Mitral Valve Atresia	Aortic Valve Atresia, In Hypoplastic Left Heart Syndrome
Ascending Aorta Hypoplasia, In Hypoplastic Left Heart Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01514	BIRC6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	BIRC6	VGNC	VGNC:26502
Rattus norvegicus	BIRC6	RGD	RGD:1307247
Felis catus	BIRC6	VGNC	VGNC:80031
Mus musculus	BIRC6	MGD	MGI:1276108
Canis familiaris	BIRC6	VGNC	VGNC:38462
Macaca mulatta	BIRC6	VGNC	VGNC:81365

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