Relb - avian reticuloendotheliosis viral (v-rel) oncogene related B Gene

中文名称：禽网状内皮增生病毒 (v-rel) 致癌基因相关 B

种属: Mus musculus

同用名: shep

关于 Relb

功能概要

该基因编码的蛋白可启动 DNA 结合转录激活剂活性，RNA 聚合酶 II 特异性； RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性；和相同的蛋白质结合活性。参与基因表达的昼夜节律调节；转录的负调控，DNA 模板化；和 RNA 聚合酶 II 对转录的正调控。作用于多个过程的上游或内部，包括 NIK/NF-kappaB 信号；抗原加工和呈递；和单核细胞分化。位于细胞质和细胞核中。以轴向骨架表示；眼睛;心;和输尿管。用于研究特应性皮炎。该基因与乳腺癌和免疫缺陷 53 相关的人类直向同源基因。与人类 RelB 直向同源基因（RELB 原癌基因，NF-kB 亚基）。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in circadian regulation of gene expression; negative regulation of transcription, DNA-templated; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including NIK/NF-kappaB signaling; antigen processing and presentation; and mononuclear cell differentiation. Located in cytosol and nucleus. Is expressed in axial skeleton; eye; heart; and ureter. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in breast Cancer and immunodeficiency 53. Orthologous to human RelB (RelB proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]