EIF5A - eukaryotic translation initiation factor 5A Gene

中文名称：真核翻译起始因子 5A

种属: Homo sapiens

同用名: FABAS; EIF-5A; EIF5A1; eIF-4D; eIF5AI

基因 ID: 1984 | 基因类型: protein coding

关于 EIF5A

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,306,999-7,312,463 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 207 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in esophagus (RPKM 53.8), appendix (RPKM 49.4) and 25 other tissues.

功能概要

启用 U6 snRNA 结合活性和蛋白质 N 末端结合活性。参与多个过程，包括细胞对病毒的反应； p53 类介质对内在凋亡信号通路的正向调控；和肿瘤坏死因子介导的信号通路。位于环状片层；细胞质；和核。核孔的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables U6 snRNA binding activity and protein N-terminus binding activity. Involved in several processes, including cellular response to virus; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and tumor necrosis factor-mediated signaling pathway. Located in annulate lamellae; cytoplasm; and nucleus. Part of nuclear pore. [provided by Alliance of Genome Resources, Apr 2022]

EIF5A 基因产物(6)

mRNA	Protein	Name
NM_001143760.1	NP_001137232.1	eukaryotic translation initiation factor 5A-1 isoform A
NM_001143761.1	NP_001137233.1	eukaryotic translation initiation factor 5A-1 isoform B
NM_001143762.2	NP_001137234.1	eukaryotic translation initiation factor 5A-1 isoform B
NM_001370420.1	NP_001357349.1	eukaryotic translation initiation factor 5A-1 isoform B
NM_001370421.1	NP_001357350.1	eukaryotic translation initiation factor 5A-1 isoform B
NM_001970.5	NP_001961.1	eukaryotic translation initiation factor 5A-1 isoform B

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA binding	IDA IDA: 通过直接分析推断	15303967	GOA
enables U6 snRNA binding	IDA IDA: 通过直接分析推断	9285100	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9442029	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to virus	IMP IMP: 通过突变表型推断	8596953	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IDA IDA: 通过直接分析推断	15371445	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	15371445	GOA
involved in translational elongation	IMP IMP: 通过突变表型推断	29712776	GOA
involved in tumor necrosis factor-mediated signaling pathway	IDA IDA: 通过直接分析推断	17187778	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in annulate lamellae	IDA IDA: 通过直接分析推断	12210765	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	12210765	GOA
part of nuclear pore	IDA IDA: 通过直接分析推断	10381392	GOA
located in nucleus	IDA IDA: 通过直接分析推断	12210765	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EIF5A 蛋白结构

eIF-5a

0
100
154 a.a.

蛋白主名

其他名称

eukaryotic translation initiation factor 5A-1

eukaryotic initiation factor 5A

EIF5A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	EIF5A	P63241	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
种属内	EIF5A	P63241	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
种属内	EIF5A	P63241	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
种属内	EIF5A	P63241	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
种属内	EIF5A	P63241	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
种属内	EIF5A	P63241	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
种属内	EIF5A	P63241	MEI4	Homo sapiens	A8MW99	Y2H Array	32296183
种属内	EIF5A	P63241	MEI4	Homo sapiens	A8MW99	Y2H Prey Pooling	32296183
种属内	EIF5A	P63241	GSC2	Homo sapiens	O15499	Y2H Array	32296183
种属内	EIF5A	P63241	GSC2	Homo sapiens	O15499	Y2H Prey Pooling	32296183
种属内	EIF5A	P63241	LBX1	Homo sapiens	P52954	Y2H Array	32296183
种属内	EIF5A	P63241	LBX1	Homo sapiens	P52954	Y2H Prey Pooling	32296183
种属内	EIF5A	P63241	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
种属内	EIF5A	P63241	REL	Homo sapiens	Q04864	Validated Y2H	25416956
种属内	EIF5A	P63241	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
种属内	EIF5A	P63241	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183
种属内	EIF5A	P63241	DHPS	Homo sapiens	P49366	Validated Y2H	25416956
种属内	EIF5A	P63241	CRX	Homo sapiens	O43186	Validated Y2H	25416956
种属内	EIF5A	P63241	CRX	Homo sapiens	O43186	Y2H Prey Pooling	25416956
种属内	EIF5A	P63241	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
种属内	EIF5A	P63241	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
种属内	EIF5A	P63241	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
种属内	EIF5A	P63241	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 EIF5A 蛋白

目录号	产品名	蛋白编号	纯度
HY-P78232	EIF5A Protein, Human (His)	NP_001961 (M1-K154)	≥95%

关联疾病

疾病名称

别名

Faundes-Banka Syndrome

FABAS

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Syndromic X-Linked Intellectual Disability Snyder Type

Snyder-Robinson Syndrome	Mental Retardation, X-Linked, Snyder-Robinson Type
Spermine Synthase Deficiency	Srs
Snyder-Robinson Mental Retardation Syndrome	X-Linked Intellectual Disability Snyder-Robinson Type
Mental Retardation, X-Linked, Syndromic, Snyder-Robinson Type	Snyder-Robinson X-Linked Mental Retardation Syndrome

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-111522	RK-9123016	Inhibitor	99.02%	否
HY-RS04286	EIF5A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04287	EIF5A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-121722	Deoxyhypusine		/	否
HY-122039	Hypusine dihydrochloride		/	否
HY-126171	Hypusine		/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	EIF5A	MGD	MGI:106248
Rattus norvegicus	EIF5A	RGD	RGD:1308029
Others	EIF5A	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

EIF5A - eukaryotic translation initiation factor 5A Gene

关于 EIF5A

功能概要

EIF5A 基因产物(6)

EIF5A 蛋白结构

EIF5A 蛋白互作信息

重组 EIF5A 蛋白

关联疾病

直系同源

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EIF5A - eukaryotic translation initiation factor 5A Gene

关于 EIF5A

功能概要

EIF5A 基因产物(6)

EIF5A 蛋白结构

EIF5A 蛋白互作信息

重组 EIF5A 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z