1. Gene
  2. GGN - gametogenetin Gene

GGN - gametogenetin Gene

中文名称:配子发生素

种属: Homo sapiens

基因 ID: 199720 | 基因类型: protein coding

关于 GGN

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,384,267-38,388,384 (from NCBI)

This gene has 5 transcripts (splice variants), 77 orthologues, 2 paralogues and is associated with 1 phenotype. Restricted expression toward testis (RPKM 12.5).

功能概要

该基因是一种生殖细胞特异性基因,编码与 POG (生殖细胞增殖) 相互作用的蛋白质。相似小鼠基因的可变剪接转录变体编码至少三种不同的蛋白质,即配子生成素蛋白 1a、配子生成素蛋白 2 和配子生成素蛋白 3,它们分别显示核周、细胞质和核仁定位。这些蛋白质调节 POG 的定位,并可能在精子发生中发挥作用。[RefSeq 提供,2008 年 7 月]

This gene is a germ cell-specific gene that encodes proteins that interact with POG (proliferation of germ cells). Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin protein 1a, gametogenetin protein 2, and gametogenetin protein 3, which show a perinuclear, cytoplasmic, and nucleolar localization, respectively. These proteins regulate the localization of POG and may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

GGN 基因产物(1)

mRNA Protein Name
NM_152657.4 NP_689870.3 gametogenetin
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

gametogenetin

GGN 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra GGN Q86UU5 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra GGN Q86UU5 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra GGN Q86UU5 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra GGN Q86UU5 ABI2 Homo sapiens Q9NYB9-2
Y2H Array
32296183
Intra GGN Q86UU5 ABI2 Homo sapiens Q9NYB9-2
Y2H Prey Pooling
32296183
Intra GGN Q86UU5 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra GGN Q86UU5 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra GGN Q86UU5 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra GGN Q86UU5 KRTAP2-4 Homo sapiens Q9BYR9
Validated Y2H
32296183
Intra GGN Q86UU5 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra GGN Q86UU5 SH3KBP1 Homo sapiens Q96B97
Validated Y2H
32296183
Intra GGN Q86UU5 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra GGN Q86UU5 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra GGN Q86UU5 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra GGN Q86UU5 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra GGN Q86UU5 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra GGN Q86UU5 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra GGN Q86UU5 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra GGN Q86UU5 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra GGN Q86UU5 WWP2 Homo sapiens O00308
Y2H Prey Pooling
32296183
Intra GGN Q86UU5 WWP2 Homo sapiens O00308
Y2H Array
32296183
Intra GGN Q86UU5 ZMYND19 Homo sapiens Q96E35
Validated Y2H
32296183
Intra GGN Q86UU5 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
32296183
Intra GGN Q86UU5 HOMER3 Homo sapiens Q9NSC5
Y2H Prey Pooling
32296183
Intra GGN Q86UU5 HOMER3 Homo sapiens Q9NSC5
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spermatogenic Failure 69

SPGF69

Spermatogenic Failure 9

Male Infertility Due To Globozoospermia

SPGF9

Male Infertility Due To Round-Headed Spermatozoa

Globozoospermia, Complete

Globozoospermia, Total

Globozoospermia

Globozoospermia Syndrome

Round-Headed Sperm Syndrome

Globozoospermia Complete

Globozoospermia Total

Chromosome 17q12 Deletion Syndrome

17q12 Microdeletion Syndrome

Del(17)(Q12)

Monosomy 17q12

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus GGN RGD RGD:1306765
Bos taurus GGN VGNC VGNC:29341
Mus musculus GGN MGD MGI:2181461
Macaca mulatta GGN VGNC VGNC:72740
Canis familiaris GGN VGNC VGNC:41199
Others GGN NCBI