2. Gene
  3. Cxcl12 - chemokine (C-X-C motif) ligand 12 Gene

Cxcl12 - chemokine (C-X-C motif) ligand 12 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Pbsf; Sdf1; Tlsf; Tpar1; Scyb12

基因 ID: 20315 | 基因类型: protein coding

关于 Cxcl12

功能概要

This gene encodes a member of the alpha chemokine protein family. The encoded protein is secreted and functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4. The encoded protein plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Cxcl12 基因产物(3)

mRNA Protein Name
NM_001012477.2 NP_001012495.1 stromal cell-derived factor 1 isoform gamma precursor
NM_013655.4 NP_038683.1 stromal cell-derived factor 1 isoform beta precursor
NM_021704.3 NP_068350.1 stromal cell-derived factor 1 isoform alpha precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chemokine activity IDA
IDA: 通过直接分析推断
12183377 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within T cell proliferation IMP
IMP: 通过突变表型推断
12707343 MGI
acts upstream of or within ameboidal-type cell migration IMP
IMP: 通过突变表型推断
15626744 MGI
acts upstream of or within blood vessel endothelial cell migration IMP
IMP: 通过突变表型推断
15626744 MGI
acts upstream of or within brain development IDA
IDA: 通过直接分析推断
12183377 MGI
acts upstream of or within branching involved in blood vessel morphogenesis IMP
IMP: 通过突变表型推断
15626744 MGI
acts upstream of or within cell-cell adhesion IDA
IDA: 通过直接分析推断
20847314 MGI
involved in dopaminergic neuron differentiation IDA
IDA: 通过直接分析推断
22535492 MGI
acts upstream of or within germ cell development IDA
IDA: 通过直接分析推断
12900445 MGI
acts upstream of or within germ cell migration IDA
IDA: 通过直接分析推断
12900445 MGI
acts upstream of or within induction of positive chemotaxis IDA
IDA: 通过直接分析推断
12900445 MGI
acts upstream of or within motor neuron axon guidance IMP
IMP: 通过突变表型推断
16129397 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
22956548 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IGI
IGI: 通过遗传相互作用推断
22956548 MGI
acts upstream of or within positive regulation of calcium ion import IDA
IDA: 通过直接分析推断
8962122 MGI
acts upstream of or within positive regulation of cell migration IDA
IDA: 通过直接分析推断
12900445 MGI
acts upstream of or within positive regulation of chemotaxis IGI
IGI: 通过遗传相互作用推断
22956548 MGI
acts upstream of or within positive regulation of myoblast fusion IMP
IMP: 通过突变表型推断
23844157 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: 通过遗传相互作用推断
22956548 MGI
acts upstream of or within regulation of cell migration IDA
IDA: 通过直接分析推断
12183377 MGI
acts upstream of or within regulation of cell migration IGI
IGI: 通过遗传相互作用推断
19064997 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
19008373 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

stromal cell-derived factor 1

12-O-tetradecanoylphorbol 13-acetate repressed protein 1

pre-B-cell growth-stimulating factor

thymic lymphoma cell-stimulating factor

重组 Cxcl12 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7285 SDF-1 alpha/CXCL12 Protein, Mouse P40224-1 (K22-K89) ≥95%
HY-P7403 SDF-1 alpha/CXCL12 Protein, Mouse (68a.a, CHO) P40224-1 (K22-K89) ≥95%
HY-P72782 SDF-1 beta/CXCL12 Protein, Mouse P40224-2 (K22-M93) ≥95%
HY-P700219AF Animal-Free SDF-1 alpha/CXCL12 Protein, Mouse (His) P40224 (G21-K89) ≥95%

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-114244 USL311 Antagonist 99.97% Phase 2
HY-13696 MSX-122 Antagonist 98.92% Phase 1
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99272 Ulocuplumab Antagonist 99.90% Phase 3
Pre-clinical Phase
生物活性分子 (28)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-142617 ACT-1004-1239 Antagonist 99.80% 否
HY-101458A IT1t dihydrochloride 99.77% 否
HY-110318 VUF11207 fumarate Agonist 98.50% 否
HY-139643 CXCR7 antagonist-1 Antagonist 99.85% 否
HY-15478 WZ811 Antagonist 99.80% 否
HY-15971 AMD 3465 hexahydrobromide ≥98.0% 否
HY-139643A CXCR7 antagonist-1 hydrochloride Antagonist 99.41% 否
HY-P1103 CTCE-9908 Antagonist 99.47% 否
HY-15971A AMD 3465 99.59% 否
HY-112709 LIT-927 99.86% 否
HY-101458 IT1t / 否
HY-N3255 Minecoside Inhibitor 99.86% 否
HY-160041 Olaptesed pegol Inhibitor / 否
HY-160041A Olaptesed pegol sodium Inhibitor / 否
HY-129094 ICT5040 Antagonist / 否
HY-131374 TN14003 Inhibitor / 否
HY-139906 CXCL12 ligand 1 Agonist / 否
HY-146372 CXCR4 antagonist 5 Antagonist / 否
HY-146401 CXCR4 antagonist 6 Antagonist / 否
HY-147978 CXCR4 antagonist 8 Antagonist / 否
HY-147979 CXCR4 antagonist 9 Antagonist / 否
HY-167851 CCX662 Antagonist / 否
HY-168095 CXCR4 antagonist 10 Inhibitor / 否
HY-P10321 HBP08 / 否
HY-P10415 EPI-X4 Antagonist 98.80% 否
HY-P1103A CTCE-9908 TFA Antagonist / 否
HY-RS03386 CXCL12 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W104862 4-Amino-D-phenylalanine Inhibitor / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990390 Anti-CXCL12/SDF1a Antibody / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cxcl12 NCBI NCBI:6387
Canis familiaris Cxcl12 NCBI NCBI:449622
Rattus norvegicus Cxcl12 NCBI NCBI:24772
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