2. Gene
  3. Cxcl12 - C-X-C motif chemokine ligand 12 Gene

Cxcl12 - C-X-C motif chemokine ligand 12 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Sdf1

基因 ID: 24772 | 基因类型: protein coding

关于 Cxcl12

功能概要

Predicted to enable CXCR Chemokine Receptor binding activity; chemokine activity; and Integrin binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; nervous system development; and regulation of ion transport. Located in several cellular components, including extracellular space; nucleus; and plasma membrane. Used to study myocardial infarction. Biomarker of anti-basement membrane glomerulonephritis; brain ischemia; myocardial infarction; status epilepticus; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Orthologous to human CXCL12 (C-X-C motif chemokine ligand 12). [provided by Alliance of Genome Resources, Apr 2022]

Cxcl12 基因产物(3)

mRNA Protein Name
NM_001033882.1 NP_001029054.1 stromal cell-derived factor 1 isoform beta precursor
NM_001033883.1 NP_001029055.1 stromal cell-derived factor 1 isoform gamma precursor
NM_022177.3 NP_071513.1 stromal cell-derived factor 1 isoform alpha precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adult locomotory behavior IMP
IMP: 通过突变表型推断
19303923 RGD
involved in animal organ regeneration IMP
IMP: 通过突变表型推断
17148669 RGD
involved in detection of mechanical stimulus involved in sensory perception of pain IMP
IMP: 通过突变表型推断
27760212 RGD
involved in detection of temperature stimulus involved in sensory perception of pain IMP
IMP: 通过突变表型推断
27760212 RGD
involved in neuron migration IDA
IDA: 通过直接分析推断
12401342 RGD
involved in positive regulation of axon extension involved in axon guidance IMP
IMP: 通过突变表型推断
18701697 RGD
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
11820456 RGD
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
17425785 RGD
involved in positive regulation of dopamine secretion IDA
IDA: 通过直接分析推断
18671738 RGD
involved in positive regulation of endothelial cell proliferation IMP
IMP: 通过突变表型推断
18690419 RGD
involved in positive regulation of neuron differentiation IMP
IMP: 通过突变表型推断
17425785 RGD
involved in regulation of calcium ion transport IDA
IDA: 通过直接分析推断
18671738 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
17581219 RGD
involved in response to mechanical stimulus IEP
IEP: 通过表达模式推断
17145991 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
19294511 RGD
involved in response to ultrasound IEP
IEP: 通过表达模式推断
25181476 RGD
involved in telencephalon cell migration IMP
IMP: 通过突变表型推断
16971524 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
11820456 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

stromal cell-derived factor 1

SDF-1 gamma

chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)

stromal cell-derived factor-1 gamma

重组 Cxcl12 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7286 SDF-1 alpha/CXCL12 Protein, Rat Q9QZD1/Q80YV8 (K22-K89) ≥95%
HY-P72781 SDF-1 beta/CXCL12 Protein, Rat NP_001029054.1 (K22-M93) ≥95%

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-114244 USL311 Antagonist 99.97% Phase 2
HY-13696 MSX-122 Antagonist 98.92% Phase 1
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99272 Ulocuplumab Antagonist 99.90% Phase 3
Pre-clinical Phase
生物活性分子 (25)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-142617 ACT-1004-1239 Antagonist 99.80% 是
HY-110318 VUF11207 fumarate Agonist 98.50% 否
HY-101458A IT1t dihydrochloride 99.77% 否
HY-139643 CXCR7 antagonist-1 Antagonist 99.97% 否
HY-15478 WZ811 Antagonist 99.79% 否
HY-15971 AMD 3465 hexahydrobromide ≥98.0% 否
HY-139643A CXCR7 antagonist-1 hydrochloride Antagonist 99.66% 否
HY-P1103 CTCE-9908 Antagonist 99.47% 否
HY-15971A AMD 3465 99.59% 否
HY-112709 LIT-927 99.86% 否
HY-101458 IT1t / 否
HY-N3255 Minecoside Inhibitor 99.86% 否
HY-160041 Olaptesed pegol Inhibitor / 否
HY-160041A Olaptesed pegol sodium Inhibitor / 否
HY-129094 ICT5040 Antagonist / 否
HY-131374 TN14003 Inhibitor / 否
HY-139906 CXCL12 ligand 1 Inhibitor / 否
HY-146372 CXCR4 antagonist 5 Antagonist / 否
HY-146401 CXCR4 antagonist 6 Antagonist / 否
HY-147978 CXCR4 antagonist 8 Antagonist / 否
HY-147979 CXCR4 antagonist 9 Antagonist / 否
HY-168095 CXCR4 antagonist 10 Inhibitor / 否
HY-P10415 EPI-X4 Antagonist / 否
HY-P1103A CTCE-9908 TFA Antagonist / 否
HY-RS03386 CXCL12 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cxcl12 NCBI NCBI:6387
Canis familiaris Cxcl12 NCBI NCBI:449622
Mus musculus Cxcl12 NCBI NCBI:20315
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