Snca - synuclein, alpha Gene

中文名称：突触核蛋白，阿尔法

种属: Mus musculus

同用名: NACP; alphaSYN; alpha-Syn

关于 Snca

功能概要

该基因编码的蛋白可启动花生四烯酸结合活性；组蛋白结合活性；和相同的蛋白质结合活性。参与多个过程，包括肽基丝氨酸磷酸化的正调节；含蛋白质的复杂组装；和突触小泡内吞作用。作用于多个过程的上游或内部，包括化学突触传递；化学突触传递的调节；和调节胺运输。位于多种细胞成分中，包括包涵体；神经细胞体；和突触小泡膜。以多种结构表达，包括大脑；泌尿生殖系统；肝;视网膜；和脾脏。用于研究帕金森病 1 和帕金森病 4。该基因与阿尔茨海默病相关的人类直向同源基因；路易体痴呆；帕金森病；帕金森病 1；和帕金森病 4. 与人类 SNCA（突触核蛋白 alpha）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables arachidonic acid binding activity; histone binding activity; and identical protein binding activity. Involved in several processes, including positive regulation of peptidyl-serine phosphorylation; protein-containing complex assembly; and synaptic vesicle endocytosis. Acts upstream of or within several processes, including chemical synaptic transmission; modulation of chemical synaptic transmission; and regulation of amine transport. Located in several cellular components, including inclusion body; neuronal cell body; and synaptic vesicle membrane. Is expressed in several structures, including brain; genitourinary system; liver; retina; and spleen. Used to study Parkinson's disease 1 and Parkinson's disease 4. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; Parkinson's disease 1; and Parkinson's disease 4. Orthologous to human SNCA (synuclein alpha). [provided by Alliance of Genome Resources, Apr 2022]