ETS2 - ETS proto-oncogene 2, transcription factor Gene

中文名称：ETS 原癌基因 2，转录因子

种属: Homo sapiens

同用名: ETS2IT1

基因 ID: 2114 | 基因类型: protein coding

关于 ETS2

Cytogenetic location: 21q22.2 Genomic coordinates (GRCh38): 21:38,805,183-38,824,955 (from NCBI)

This gene has 9 transcripts (splice variants), 155 orthologues and 28 paralogues. Ubiquitous expression in spleen (RPKM 50.4), small intestine (RPKM 39.5) and 22 other tissues.

功能概要

该基因编码一种转录因子，该因子调节参与发育和细胞凋亡的基因。编码的蛋白质也是一种原癌基因，并显示参与端粒酶的调节。该基因的假基因位于 X 染色体上。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 1 月]

This gene encodes a transcription factor which regulates genes involved in development and Apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of Telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

ETS2 基因产物(2)

mRNA	Protein	Name
NM_001256295.2	NP_001243224.1	protein C-ets-2 isoform 2
NM_005239.6	NP_005230.1	protein C-ets-2 isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	12637547	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	12637547	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA IDA: 通过直接分析推断	11909962	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	11909962	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	18242510	GOA
enables protein domain specific binding	IPI IPI: 通过物理相互作用推断	11583620	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	12637547	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	11909962	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ETS2 蛋白结构

SAM_PNT

Ets

0
100
200
300
400
469 a.a.

蛋白主名

其他名称

protein C-ets-2

oncogene ETS-2

ETS2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ETS2	P15036	COP1	Homo sapiens	Q8NHY2	Anti Tag CoIP	25117710
种属内	ETS2	P15036	COP1	Homo sapiens	Q8NHY2	Anti Tag CoIP	26496610
种属内	ETS2	P15036	CDK10	Homo sapiens	Q15131	Anti Bait CoIP	18242510
种属内	ETS2	P15036	CDK10	Homo sapiens	Q15131	Anti Tag CoIP	18242510
种属内	ETS2	P15036	TWIST1	Homo sapiens	Q15672	Anti Bait CoIP	18598946
种属内	ETS2	P15036	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
种属内	ETS2	P15036	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
种属内	ETS2	P15036	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
种属内	ETS2	P15036	SERPINH1	Homo sapiens	P50454	Y2H Pooling	32814053
种属内	ETS2	P15036	SERPINH1	Homo sapiens	P50454	Validated Y2H	32814053
种属内	ETS2	P15036	SERPINH1	Homo sapiens	P50454	Y2H Array	32814053
种属内	ETS2	P15036	TP53	Homo sapiens	P04637	Anti Bait CoIP	26331536
种属内	ETS2	P15036	TP53	Homo sapiens	P04637	Pull Down	26331536
种属内	ETS2	P15036	TP53	Homo sapiens	P04637	Anti Tag CoIP	26331536
种属内	ETS2	P15036	PRKACA	Homo sapiens	P17612	Validated Y2H	32814053
种属内	ETS2	P15036	PRKACA	Homo sapiens	P17612	Y2H Array	32814053
种属内	ETS2	P15036	PRKACA	Homo sapiens	P17612	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Choriocarcinoma

Chorioepithelioma

Acute Megakaryocytic Leukemia

Acute Megakaryoblastic Leukemia	Acute Megakaryoblastic Leukaemia
Megakaryocytic Myelosis	Thrombocytic Leukaemia
Amkl	Aml M7
Acute Myeloblastic Leukemia Type 7	Acute Myeloid Leukemia M7
Megakaryoblastic Leukemia Acute	Leukemia, Megakaryoblastic, Acute
Acute Myeloid Leukaemia, M7	Acute Megakaryocytic Leukaemia
Acute Megakaryoblastic Leukaemia, Fab M7	Fab M7
Malignant Megakaryocytosis	M7 - Acute Megakaryoblastic Leukaemia
Megakaryoblastic Leukaemia	Megakaryocytic Leukaemia
Acute Megakaryoblastic Leukaemia, Nos	Acute Megakaryoblastic Leukaemia Without Mention Of Remission

Down Syndrome

Trisomy 21	Complete Trisomy 21 Syndrome
Down'S Syndrome	Trisomy 21 Syndrome
Down'S Syndrome - Trisomy 21	Downs Syndrome
G Trisomy	47,Xx,+21
47,Xy,+21	Trisomy G
Down Syndrome, Susceptibility To	Chromosome 21 Trisomy
Trisomy 21 Nos	Abnormal Autosomes 21

Endometrium Carcinoma In Situ

Carcinoma In Situ Of Endometrium

Endometrial Carcinoma In Situ

Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome	Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome
Syndactyly With Renal And Anogenital Malformations	STAR
Syndactyly, Telecanthus, Anogenital And Renal Malformations	Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations

Hyperhidrosis, Gustatory

Frey Syndrome	Gustatory Sweating
Auriculotemporal Nerve Syndrome	Gustatory Hyperhidrosis
Frey'S Syndrome	Sweating, Gustatory
HYPRG	Baillarger Syndrome
Hyperhidrosis Gustatory	Auriculotemporal Syndrome

Myeloproliferative Syndrome, Transient

Transient Abnormal Myelopoiesis	Transient Myeloproliferative Syndrome
Transient Myeloproliferative Disease	Mst
Tam	Leukemia, Transient, Of Down Syndrome
Tmd	Leukemia, Transient
Transient Leukemia	Transient Leukemia Of Down Syndrome

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Chromosomal Duplication Syndrome

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Chromosomal Disease

Chromosomal Disorders

Congenital Chromosomal Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04563	ETS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	ETS2	MGD	MGI:95456
Felis catus	ETS2	VGNC	VGNC:61981
Canis familiaris	ETS2	VGNC	VGNC:40495
Rattus norvegicus	ETS2	RGD	RGD:1584977
Macaca mulatta	ETS2	VGNC	VGNC:72440
Bos taurus	ETS2	VGNC	VGNC:28627

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ETS2 - ETS proto-oncogene 2, transcription factor Gene

关于 ETS2

功能概要

ETS2 基因产物(2)

ETS2 蛋白结构

ETS2 蛋白互作信息

关联疾病

直系同源

热门区域

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ETS2 - ETS proto-oncogene 2, transcription factor Gene

关于 ETS2

功能概要

ETS2 基因产物(2)

ETS2 蛋白结构

ETS2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z