1. Gene
  2. Cntn2 - contactin 2 Gene

Cntn2 - contactin 2 Gene

种属: Mus musculus

同用名: Tax; TAG1; TAG-1; D130012K04Rik

基因 ID: 21367 | 基因类型: protein coding

关于 Cntn2

功能概要

This gene encodes a member of the contactin family of proteins, part of the immunoglobulin superfamily of cell adhesion molecules. The encoded glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein plays a role in the proliferation, migration, and axon guidance of neurons of the developing cerebellum. Mice lacking a functional copy of this gene exhibit epileptic seizures and elevated expression of A1 adenosine receptors. [provided by RefSeq, Sep 2016]

Cntn2 基因产物(1)

mRNA Protein Name
NM_177129.5 NP_796103.2 contactin-2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables carbohydrate binding IDA
IDA: 通过直接分析推断
19458237 MGI
enables cell adhesion mediator activity IMP
IMP: 通过突变表型推断
18650339 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
18550718 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of G protein-coupled adenosine receptor signaling pathway IMP
IMP: 通过突变表型推断
11178983 MGI
acts upstream of or within adult walking behavior IMP
IMP: 通过突变表型推断
18760366 MGI
acts upstream of or within axon guidance IGI
IGI: 通过遗传相互作用推断
18550718 MGI
acts upstream of or within axon guidance IMP
IMP: 通过突变表型推断
18550718 MGI
acts upstream of or within axonal fasciculation IMP
IMP: 通过突变表型推断
18650339 MGI
acts upstream of or within central nervous system myelination IMP
IMP: 通过突变表型推断
18650339 MGI
acts upstream of or within cerebral cortex GABAergic interneuron migration IMP
IMP: 通过突变表型推断
11714688 MGI
involved in clustering of voltage-gated potassium channels IMP
IMP: 通过突变表型推断
12963709 MGI
acts upstream of or within establishment of localization in cell IDA
IDA: 通过直接分析推断
18550718 MGI
involved in establishment of protein localization to juxtaparanode region of axon IDA
IDA: 通过直接分析推断
12975355 MGI
involved in fat cell differentiation IMP
IMP: 通过突变表型推断
22752552 MGI
acts upstream of or within learning IMP
IMP: 通过突变表型推断
18760366 MGI
acts upstream of or within microtubule cytoskeleton organization IMP
IMP: 通过突变表型推断
18650339 MGI
acts upstream of or within negative regulation of neuron differentiation IGI
IGI: 通过遗传相互作用推断
18278038 MGI
acts upstream of neuron differentiation IGI
IGI: 通过遗传相互作用推断
18278038 MGI
acts upstream of or within neuron migration IMP
IMP: 通过突变表型推断
11807022 MGI
acts upstream of or within neuron projection development IGI
IGI: 通过遗传相互作用推断
19458237 MGI
acts upstream of or within positive regulation of adenosine receptor signaling pathway IMP
IMP: 通过突变表型推断
11178983 MGI
acts upstream of or within positive regulation of protein processing IDA
IDA: 通过直接分析推断
18278038 MGI
acts upstream of or within protein localization to juxtaparanode region of axon IGI
IGI: 通过遗传相互作用推断
20962216 MGI
acts upstream of or within protein localization to juxtaparanode region of axon IMP
IMP: 通过突变表型推断
18760366 MGI
involved in protein localization to juxtaparanode region of axon IMP
IMP: 通过突变表型推断
12963709 MGI
acts upstream of protein processing IDA
IDA: 通过直接分析推断
18278038 MGI
acts upstream of or within receptor internalization IDA
IDA: 通过直接分析推断
18550718 MGI
involved in reduction of food intake in response to dietary excess IMP
IMP: 通过突变表型推断
22752552 MGI
acts upstream of or within regulation of astrocyte differentiation IMP
IMP: 通过突变表型推断
18650339 MGI
acts upstream of or within regulation of axon diameter IMP
IMP: 通过突变表型推断
18650339 MGI
involved in regulation of cell morphogenesis IMP
IMP: 通过突变表型推断
18650339 MGI
acts upstream of or within regulation of neuronal synaptic plasticity IMP
IMP: 通过突变表型推断
11178983 MGI
involved in response to dietary excess IMP
IMP: 通过突变表型推断
22752552 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
8089271 MGI
is active in axon initial segment IDA
IDA: 通过直接分析推断
18509034 MGI
located in cell surface IDA
IDA: 通过直接分析推断
8089271 MGI
located in juxtaparanode region of axon IDA
IDA: 通过直接分析推断
12963709 MGI
located in myelin sheath IDA
IDA: 通过直接分析推断
12963709 MGI
located in neuron projection IDA
IDA: 通过直接分析推断
18650339 MGI
located in neuronal cell body IDA
IDA: 通过直接分析推断
8089271 MGI
located in node of Ranvier IDA
IDA: 通过直接分析推断
12963709 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

contactin-2

TAX-1

axonal glycoprotein TAG-1

axonin

axonin-1

transient axonal glycoprotein 1

重组 Cntn2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74223 Contactin-2/CNTN2 Protein, Mouse (HEK293, His) Q61330 (Q31-E1013) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cntn2 NCBI NCBI:6900