ALCAM - activated leukocyte cell adhesion molecule Gene

中文名称：活化的白细胞粘附分子

种属: Homo sapiens

同用名: MEMD; CD166

基因 ID: 214 | 基因类型: protein coding

关于 ALCAM

Cytogenetic location: 3q13.11 Genomic coordinates (GRCh38): 3:105,366,909-105,576,900 (from NCBI)

This gene has 9 transcripts (splice variants), 258 orthologues and 3 paralogues. Broad expression in lung (RPKM 33.7), brain (RPKM 28.3) and 24 other tissues.

功能概要

该基因编码活化的白细胞细胞粘附分子 (ALCAM) ，也称为 CD166 (分化簇 166) ，它是免疫球蛋白受体亚家族的成员，在胞外域中具有五个免疫球蛋白样结构域 (VVC2C2C2) 。该蛋白与 T 细胞分化抗原 CD6 结合，并参与细胞粘附和迁移过程。已发现编码不同亚型的多个选择性剪接转录物变体。[RefSeq 提供，2011 年 8 月]

This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011]

ALCAM 基因产物(4)

mRNA	Protein	Name
NM_001243280.2	NP_001230209.1	CD166 antigen isoform 2 precursor
NM_001243281.2	NP_001230210.1	CD166 antigen isoform 3 precursor
NM_001243283.2	NP_001230212.1	CD166 antigen isoform 4 precursor
NM_001627.4	NP_001618.2	CD166 antigen isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	26146185	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	24945728	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP IMP: 通过突变表型推断	16352806	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of T cell receptor complex	IDA IDA: 通过直接分析推断	15294938	GOA
located in immunological synapse	IDA IDA: 通过直接分析推断	15294938	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	15294938	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ALCAM 蛋白结构

V-set

C2-set_2

Ig_2

Ig_3

0
100
200
300
400
500
583 a.a.

蛋白主名

其他名称

CD166 antigen

ALCAM 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ALCAM	Q13740	LGALS1	Homo sapiens	P09382	Competition Binding	24945728
种属内	ALCAM	Q13740	LGALS1	Homo sapiens	P09382	ELISA	24945728
种属内	ALCAM	Q13740	LGALS1	Homo sapiens	P09382	Anti Tag CoIP	33961781
种属内	ALCAM	Q13740	LGALS3	Homo sapiens	P17931	Pull Down	24945728
种属内	ALCAM	Q13740	LGALS3	Homo sapiens	P17931	ELISA	24945728
种属内	ALCAM	Q13740	ALCAM	Homo sapiens	Q13740	GMS	26146185
种属内	ALCAM	Q13740	CD6	Homo sapiens	P30203	Competition Binding	24945728
种属内	ALCAM	Q13740	CD6	Homo sapiens	P30203	ELISA	24945728
种属内	ALCAM	Q13740	ALCAM	Homo sapiens	Q13740	Light Scattering	26146185
种属内	ALCAM	Q13740	ALCAM	Homo sapiens	Q13740	SLCA	26146185
种属内	ALCAM	Q13740	ABCC1	Homo sapiens	P33527	Anti Tag CoIP	35271311

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ALCAM 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7471	ALCAM/CD166 Protein, Human (HEK293, Fc)	Q13740 (W28-A526)	≥95%
HY-P78056	ALCAM/CD166 Protein, Human (Biotinylated, HEK293, His)	Q13740 (W28-A526)	≥95%
HY-P78057	ALCAM/CD166 Protein, Human (Biotinylated, HEK293, His-Avi)	Q13740 (W28-A526)	≥95%

ALCAM 抗体

目录号	产品名	应用	反应物种
HY-P81138	CD166 Antibody	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Stork Bite

Salmon Patch Nevus

Unna'S Nevus

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00557	ALCAM Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P99788	Praluzatamab	Inhibitor	95.00%	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	ALCAM	MGD	MGI:1313266
Canis familiaris	ALCAM	VGNC	VGNC:37779
Rattus norvegicus	ALCAM	RGD	RGD:619972
Bos taurus	ALCAM	VGNC	VGNC:25805
Macaca mulatta	ALCAM	VGNC	VGNC:69783
Felis catus	ALCAM	VGNC	VGNC:59735
Macaca fascicularis	ALCAM	NCBI	NCBI:101867493
Others	ALCAM	NCBI

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ALCAM - activated leukocyte cell adhesion molecule Gene

关于 ALCAM

功能概要

ALCAM 基因产物(4)

ALCAM 蛋白结构

ALCAM 蛋白互作信息

重组 ALCAM 蛋白

ALCAM 抗体

关联疾病

直系同源

热门区域

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ALCAM - activated leukocyte cell adhesion molecule Gene

关于 ALCAM

功能概要

ALCAM 基因产物(4)

ALCAM 蛋白结构

ALCAM 蛋白互作信息

重组 ALCAM 蛋白

ALCAM 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z