1. Gene
  2. DOK6 - docking protein 6 Gene

DOK6 - docking protein 6 Gene

中文名称:对接蛋白 6

种属: Homo sapiens

同用名: DOK5L; HsT3226

基因 ID: 220164 | 基因类型: protein coding

关于 DOK6

Cytogenetic location: 18q22.2 Genomic coordinates (GRCh38): 18:69,400,888-69,849,087 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 7 paralogues. Biased expression in brain (RPKM 6.3), kidney (RPKM 1.5) and 10 other tissues.

功能概要

DOK6 是 DOK (参见 DOK1;MIM 602919) 细胞内适配器家族的成员,在 RET (MIM 164761) 信号级联中发挥作用 (Crowder 等人,2004 [PubMed 15286081]) 。[OMIM 提供,3 月 2008]

DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008]

DOK6 基因产物(1)

mRNA Protein Name
NM_152721.6 NP_689934.2 docking protein 6
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16273093 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DOK6 蛋白结构

PH

PH: PH domain (8 - 109)

IRS

IRS: PTB domain (IRS-1 type) (136 - 230)

  • 0
  • 100
  • 200
  • 300
  • 331 a.a.
蛋白主名 其他名称

docking protein 6

downstream of tyrosine kinase 6

DOK6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DOK6 Q6PKX4 TBX15 Homo sapiens Q96SF7
Validated Y2H
32296183
Intra DOK6 Q6PKX4 TBX15 Homo sapiens Q96SF7
Y2H Array
32296183
Intra DOK6 Q6PKX4 TBX15 Homo sapiens Q96SF7
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 LGALS14 Homo sapiens Q8TCE9
Validated Y2H
32296183
Intra DOK6 Q6PKX4 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra DOK6 Q6PKX4 USP54 Homo sapiens Q70EL1-9
Validated Y2H
32296183
Intra DOK6 Q6PKX4 USP54 Homo sapiens Q70EL1-9
Y2H Array
32296183
Intra DOK6 Q6PKX4 USP54 Homo sapiens Q70EL1-9
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 ABHD11 Homo sapiens Q8NFV4-4
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 ABHD11 Homo sapiens Q8NFV4-4
Y2H Array
32296183
Intra DOK6 Q6PKX4 ABHD11 Homo sapiens Q8NFV4-4
Validated Y2H
32296183
Intra DOK6 Q6PKX4 FAM86C1P Homo sapiens Q9NVL1-2
Validated Y2H
32296183
Intra DOK6 Q6PKX4 FAM86C1P Homo sapiens Q9NVL1-2
Y2H Array
32296183
Intra DOK6 Q6PKX4 FAM86C1P Homo sapiens Q9NVL1-2
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 SLC30A6 Homo sapiens Q6NXT4-4
Y2H Array
32296183
Intra DOK6 Q6PKX4 SLC30A6 Homo sapiens Q6NXT4-4
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 CRYBB3 Homo sapiens P26998
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 CRYBB3 Homo sapiens P26998
Y2H Array
32296183
Intra DOK6 Q6PKX4 NTRK3 Homo sapiens Q16288
Y2H
20565848
Intra DOK6 Q6PKX4 NTRK3 Homo sapiens Q16288
Anti Tag CoIP
20565848
Intra DOK6 Q6PKX4 NTRK3 Homo sapiens Q16288
Pull Down
20565848
Intra DOK6 Q6PKX4 RUSC1 Homo sapiens Q9BVN2
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 RUSC1 Homo sapiens Q9BVN2
Y2H Array
32296183
Intra DOK6 Q6PKX4 RUSC1 Homo sapiens Q9BVN2
Validated Y2H
32296183
Intra DOK6 Q6PKX4 RBPMS Homo sapiens Q93062
Y2H Array
25416956
Intra DOK6 Q6PKX4 METTL27 Homo sapiens Q8N6F8
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 METTL27 Homo sapiens Q8N6F8
Validated Y2H
32296183
Intra DOK6 Q6PKX4 METTL27 Homo sapiens Q8N6F8
Y2H Array
32296183
Intra DOK6 Q6PKX4 LASP1 Homo sapiens Q14847-2
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 LASP1 Homo sapiens Q14847-2
Y2H Array
32296183
Intra DOK6 Q6PKX4 C1orf94 Homo sapiens Q6P1W5
Validated Y2H
25416956
Intra DOK6 Q6PKX4 C1orf94 Homo sapiens Q6P1W5
Y2H Array
25416956
Intra DOK6 Q6PKX4 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 ARID5A Homo sapiens Q03989
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Malignant Iris Melanoma

Malignant Melanoma Of Iris

Melanoma Of The Iris

Hirschsprung Disease 1

Hirschsprung Disease

Aganglionic Megacolon

Hscr

Hirschsprung'S Disease

Congenital Megacolon

Congenital Intestinal Aganglionosis

Colonic Aganglionosis

Hirschsprung Disease, Susceptibility To, 1

Hirschsprung Disease, Protection Against

HSCR1

Mgc

Pelvirectal Achalasia

Total Intestinal Aganglionosis

Megacolon, Aganglionic

Macrocolon

Hscr 1

Hirschsprung Disease Type 1

Hirschsprung Disease, Type 1

Congenital Dilatation Of Colon

Aganglionosis

Congenital Aganglionic Megacolon

Aganglionosis Of Colon

Bowel Aganglionosis

Colon Aganglionosis

Hirschsprung Megacolon

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus DOK6 VGNC VGNC:61585
Mus musculus DOK6 MGD MGI:3639495
Bos taurus DOK6 VGNC VGNC:28169
Macaca mulatta DOK6 VGNC VGNC:71915
Rattus norvegicus DOK6 RGD RGD:1564376
Canis familiaris DOK6 VGNC VGNC:40060