FBP1 - fructose-bisphosphatase 1 Gene

中文名称：果糖双磷酸酶 1

种属: Homo sapiens

同用名: FBP

基因 ID: 2203 | 基因类型: protein coding

关于 FBP1

Cytogenetic location: 9q22.32 Genomic coordinates (GRCh38): 9:94,603,133-94,640,263 (from NCBI)

This gene has 5 transcripts (splice variants), 143 orthologues, 1 paralogue and is associated with 3 phenotypes. Biased expression in liver (RPKM 175.9), kidney (RPKM 118.4) and 9 other tissues.

功能概要

果糖 1,6-二磷酸酶 1 是一种糖异生调节酶，可催化果糖 1,6-二磷酸水解为果糖 6-磷酸和无机磷酸盐。 1,6-二磷酸果糖酶缺乏与低血糖和代谢性酸中毒有关。[RefSeq 提供，2008 年 7 月]

Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory Enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]

FBP1 基因产物(2)

mRNA	Protein	Name
NM_000507.4	NP_000498.2	fructose-1,6-bisphosphatase 1
NM_001127628.2	NP_001121100.1	fructose-1,6-bisphosphatase 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables AMP binding	IDA IDA: 通过直接分析推断	8387495	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IMP IMP: 通过突变表型推断	25043030	GOA
enables fructose 1,6-bisphosphate 1-phosphatase activity	IDA IDA: 通过直接分析推断	8387495	GOA
enables fructose 1,6-bisphosphate 1-phosphatase activity	IMP IMP: 通过突变表型推断	7558035	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16169070	GOA
enables metal ion binding	IMP IMP: 通过突变表型推断	8387495	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	8387495	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to magnesium ion	IDA IDA: 通过直接分析推断	10222032	GOA
involved in cellular response to xenobiotic stimulus	IDA IDA: 通过直接分析推断	16442285	GOA
involved in dephosphorylation	IDA IDA: 通过直接分析推断	8387495	GOA
involved in dephosphorylation	IMP IMP: 通过突变表型推断	7558035	GOA
involved in fructose 6-phosphate metabolic process	IDA IDA: 通过直接分析推断	8387495	GOA
involved in gluconeogenesis	IMP IMP: 通过突变表型推断	19259699	GOA
involved in negative regulation of Ras protein signal transduction	IDA IDA: 通过直接分析推断	19881551	GOA
involved in negative regulation of cell growth	IDA IDA: 通过直接分析推断	19881551	GOA
involved in negative regulation of glycolytic process	IDA IDA: 通过直接分析推断	19881551	GOA
involved in negative regulation of glycolytic process	IMP IMP: 通过突变表型推断	25043030	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	25043030	GOA
involved in regulation of gluconeogenesis	IMP IMP: 通过突变表型推断	7558035	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	20096900	GOA
located in nucleus	IMP IMP: 通过突变表型推断	25043030	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FBP1 蛋白结构

FBPase

0
100
200
300
338 a.a.

蛋白主名

其他名称

fructose-1,6-bisphosphatase 1

D-fructose-1,6-bisphosphate 1-phosphohydrolase 1

FBP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FBP1	P09467	HIF1A	Homo sapiens	Q16665	Anti Tag CoIP	25043030
种属内	FBP1	P09467	HIF1A	Homo sapiens	Q16665	Pull Down	25043030
种属内	FBP1	P09467	EPAS1	Homo sapiens	Q99814	Anti Bait CoIP	25043030
种属内	FBP1	P09467	EPAS1	Homo sapiens	Q99814	Pull Down	25043030
种属内	FBP1	P09467	EPAS1	Homo sapiens	Q99814	Anti Tag CoIP	25043030
种属内	FBP1	P09467	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
种属内	FBP1	P09467	HTT	Homo sapiens	P42858	Validated Y2H	32814053
种属内	FBP1	P09467	HTT	Homo sapiens	P42858	Y2H Array	32814053
种属内	FBP1	P09467	FBP1	Homo sapiens	P09467	Validated Y2H	25910212
种属内	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H Array	31515488
种属内	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H Bait-Prey Pool	25910212
种属内	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H Pooling	16169070
种属内	FBP1	P09467	FBP1	Homo sapiens	P09467	SLC	25910212
种属内	FBP1	P09467	FBP1	Homo sapiens	P09467	Validated Y2H	32296183
种属内	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H Array	25502805
种属内	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H Array	25910212
种属内	FBP1	P09467	FBP2	Homo sapiens	O00757	Validated Y2H	25910212
种属内	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H Pooling	16189514
种属内	FBP1	P09467	FBP2	Homo sapiens	O00757	Y2H Array	31515488
种属内	FBP1	P09467	FBP2	Homo sapiens	O00757	Y2H Bait-Prey Pool	25910212
种属内	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H Array	25416956
种属内	FBP1	P09467	FBP2	Homo sapiens	O00757	SLC	25910212
种属内	FBP1	P09467	FBP2	Homo sapiens	O00757	Y2H Array	25910212
种属内	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H Prey Pooling	32296183
种属内	FBP1	P09467	FBP2	Homo sapiens	O00757	Anti Tag CoIP	33961781
种属内	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H Array	32296183
种属内	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H Prey Pooling	25416956
种属内	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H	21516116
种属内	FBP1	P09467	FBP2	Homo sapiens	O00757	Y2H Prey Pooling	25416956
种属内	FBP1	P09467	FBP2	Homo sapiens	O00757	Y2H Array	25416956
种属内	FBP1	P09467	BIN1	Homo sapiens	O00499	Peptide Array	16275660
种属内	FBP1	P09467	BIN1	Homo sapiens	O00499	Y2H	16275660
种属内	FBP1	P09467	FXR2	Homo sapiens	P51116	Y2H Array	31515488
种属内	FBP1	P09467	FXR2	Homo sapiens	P51116	Y2H Pooling	16189514

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 FBP1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70275	FBP1 Protein, Human (HEK293, His)	P09467 (A2-Q338)	≥95%

FBP1 抗体

目录号	产品名	应用	反应物种
HY-P81519	FBP1 Antibody (YA1264)	IHC-P	Human, Mouse, Rat

关联疾病

疾病名称

别名

Fructose-1,6-Bisphosphatase Deficiency

Fructose-1,6-Diphosphatase Deficiency	Baker-Winegrad Disease
FBP1D	Fbpase Deficiency
Fructose 1,6 Diphosphatase Deficiency	Fructose 1 Phosphate Aldolase Deficiency
Fbp1 Deficiency	Hereditary Fructose Intolerance Syndrome

Hypoglycemia

Hypoglycaemia	Low Blood Sugar
Hypoglycaemia Nos	Spontaneous Hypoglycaemia
Nondiabetic Hypoglycaemia	Hypoglycaemic Disorder Nos
Hypoglycaemic Syndrome

Metabolic Acidosis

Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic

Acute Pyelonephritis

Apn - [Acute Pyelonephritis]

Glycogen Storage Disease Ia

Von Gierke Disease	Glycogen Storage Disease Type I
Glycogen Storage Disease I	Hepatorenal Form Of Glycogen Storage Disease
Hepatorenal Glycogenosis	Glucose-6-Phosphatase Deficiency
Glycogen Storage Disease, Type I	Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ia
GSD1A	Gsd1
Von Gierke'S Disease	Glycogen Storage Disease Type 1a
Glycogen Storage Disease 1a	Glucose-6-Phosphate Transport Defect
Gsd Ia	Deficiency Of Glucose-6-Phosphatase
Glycogenosis Type I	Glucose-6-Phosphatase Deficiency Glycogen Storage Disease
Glycogenosis Type 1	Glucose-6-Phosphate Deficiency
Gsd I	Gsd Type I
G6p Deficiency Type 1a	Gsd Due To G6p Deficiency Type 1a
Gsd Due To G6p Deficiency Type Ia	Gsd Type 1a
Gsdia	Glycogen Storage Disease Due To G6p Deficiency Type Ia
Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type 1a	Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type Ia
Glycogenosis Type Ia	Gsd-Ia
Storage Disease, Glycogen, Type 1a	Glycogen Storage Disease Type Ia

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04779	FBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	FBP1	MGD	MGI:95492
Rattus norvegicus	FBP1	RGD	RGD:2595
Bos taurus	FBP1	VGNC	VGNC:28887
Felis catus	FBP1	VGNC	VGNC:62172
Canis familiaris	FBP1	VGNC	VGNC:40757
Macaca mulatta	FBP1	VGNC	VGNC:72625
Others	FBP1	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FBP1 - fructose-bisphosphatase 1 Gene

关于 FBP1

功能概要

FBP1 基因产物(2)

FBP1 蛋白结构

FBP1 蛋白互作信息

重组 FBP1 蛋白

FBP1 抗体

关联疾病

直系同源

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FBP1 - fructose-bisphosphatase 1 Gene

关于 FBP1

功能概要

FBP1 基因产物(2)

FBP1 蛋白结构

FBP1 蛋白互作信息

重组 FBP1 蛋白

FBP1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z