FCN1 - ficolin 1 Gene

中文名称：纤维胶蛋白 1

种属: Homo sapiens

同用名: FCNM

基因 ID: 2219 | 基因类型: protein coding

关于 FCN1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:134,903,232-134,917,912 (from NCBI)

This gene has 1 transcript (splice variant), 114 orthologues and 25 paralogues. Biased expression in bone marrow (RPKM 318.5), appendix (RPKM 117.5) and 3 other tissues.

功能概要

ficolin 蛋白家族的特征在于存在一个前导肽、一个短的 N 末端片段，然后是一个胶原蛋白样区域和一个 C 末端纤维蛋白原样结构域。胶原蛋白样和纤维蛋白原样结构域也分别存在于其他蛋白质中，例如补体蛋白 C1q、称为收集素的 C 型凝集素和生腱蛋白。然而，所有这些蛋白质都识别不同的目标，并且在功能上各不相同。由 FCN1 编码的 Ficolin 1 主要在外周血白细胞中表达，并被假定为具有弹性蛋白结合活性的血浆蛋白。[RefSeq 提供，2008 年 7 月]

The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in Other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]

FCN1 基因产物(1)

mRNA	Protein	Name
NM_002003.5	NP_001994.2	ficolin-1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables G protein-coupled receptor binding	IPI IPI: 通过物理相互作用推断	21037097	GOA
enables pattern recognition receptor activity	IMP IMP: 通过突变表型推断	21037097	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17581635	GOA
enables sialic acid binding	IDA IDA: 通过直接分析推断	20400674	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	21037097	GOA
involved in cell surface pattern recognition receptor signaling pathway	IMP IMP: 通过突变表型推断	21037097	GOA
involved in complement activation, lectin pathway	IDA IDA: 通过直接分析推断	16116205	GOA
involved in negative regulation of viral entry into host cell	IDA IDA: 通过直接分析推断	22851708	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: 通过突变表型推断	21037097	GOA
involved in positive regulation of opsonization	IDA IDA: 通过直接分析推断	16116205	GOA
involved in protein localization to cell surface	IDA IDA: 通过直接分析推断	20400674	GOA
involved in proteolysis	IDA IDA: 通过直接分析推断	16116205	GOA
involved in recognition of apoptotic cell	IDA IDA: 通过直接分析推断	15804047	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	21037097	GOA
part of serine-type endopeptidase complex	IDA IDA: 通过直接分析推断	16116205	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FCN1 蛋白结构

Collagen

Fibrinogen_C

0
100
200
300
326 a.a.

蛋白主名

其他名称

ficolin-1

M-ficolin

FCN1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FCN1	O00602	CRP	Homo sapiens	P02741	ELISA	21037097
种属内	FCN1	O00602	CRP	Homo sapiens	P02741	H1-H2 MS	21037097
种属内	FCN1	O00602	CRP	Homo sapiens	P02741	PLA	21037097
种属间	FCN1	O00602	CRP-1	Carcinoscorpius rotundicauda	Q2TS39	Saturation Binding	17581635
种属间	FCN1	O00602	CRP-1	Carcinoscorpius rotundicauda	Q2TS39	Pull Down	17581635

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 FCN1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76930	Ficolin-1 Protein, Human (HEK293, His)	NP_001994.2 (A30-A326)	≥95%

关联疾病

疾病名称

别名

Rheumatic Fever

Acute Rheumatic Fever	Rhf - Rheumatic Fever
Inflammatory Rheumatism	Active Rheumatic Fever Nos
Acute Active Rheumatic Fever	Subacute Active Rheumatic Fever
Subacute Rheumatic Fever	Active Rheumatic Fever With Unspecified Type Of Heart Involvement
Acute Rheumatic Heart Disease	Active Rheumatic Heart Disease
Acute Organic Rhd - [Rheumatic Heart Disease]	Acute Rhd - [Rheumatic Heart Disease]

Pulmonary Aspergilloma

3mc Syndrome 2

3MC2	Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia
Oculo-Skeletal-Abdominal Syndrome	Osa Syndrome
Carnevale Syndrome	Carnevale Syndrome, Formerly
Carnevale Krajewska Fischetto Syndrome	3mc Syndrome, Type 2

3mc Syndrome 1

Oculopalatoskeletal Syndrome	3MC1
Craniosynostosis With Lid Anomalies	Michels Syndrome, Formerly
Michels Syndrome	3mc Syndrome, Type 1

3mc Syndrome

Craniofacial-Ulnar-Renal Syndrome	Malpuech Facial Clefting Syndrome
Oculopalatoskeletal Syndrome	Carnevale Syndrome
Michels Syndrome	Malpuech-Michels-Mingarelli-Carnevale Syndrome
Carnevale-Krajewska-Fischetto Syndrome	Craniosynostosis With Lid Anomalies
Malpuech Syndrome	Mingarelli Syndrome
Oculo-Skeletal-Abdominal Syndrome	Osa Syndrome
Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia	Ptosis-Strabismus-Rectus Abdominis Diastasis

Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Atypical Hemolytic Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To
Ahus	AHUS1
Hemolytic-Uremic Syndrome	Ahus 1
Ahus, Susceptibility To, 1	Hemolytic Uremic Syndrome, Atypical
Non-Shiga-Like Toxin-Associated Hus	Non-Stx-Hus
Nonenteropathic Hus	Atypical Hus
Shiga Toxin-Associated Hemolytic Uremic Syndrome	D+ Hus
Ehec-Hus	Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli
Hemolytic Uremic Syndrome With Diarrhea	Stec-Hus
Shiga-Like Toxin-Associated Hus	Stx-Hus
Typical Hus	Typical Hemolytic Uremic Syndrome
Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies	Atypical Hus With Anti-Factor H Antibodies
Ahus With Anti-Factor H Antibodies	Ahus With Neutralizing Autoantibodies Against Factor H
Hemolytic Uremic Syndrome Atypical 1	Atypical Hemolytic Uremic Syndrome With H Factor Anomaly
D Hus	Hemolytic-Uremic Syndrome Without Diarrhea
Hemolytic-Uremic Syndrome, Atypical, Type 1	Hemolytic Uremic Syndrome, Typical

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04839	FCN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	FCN1	MGD	MGI:1341158
Rattus norvegicus	FCN1	RGD	RGD:621222
Macaca mulatta	FCN1	NCBI
Others	FCN1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FCN1 - ficolin 1 Gene

关于 FCN1

功能概要

FCN1 基因产物(1)

FCN1 蛋白结构

FCN1 蛋白互作信息

重组 FCN1 蛋白

关联疾病

直系同源

热门区域

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FCN1 - ficolin 1 Gene

关于 FCN1

功能概要

FCN1 基因产物(1)

FCN1 蛋白结构

FCN1 蛋白互作信息

重组 FCN1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z