2. Gene
  3. FER - FER tyrosine kinase Gene

FER - FER tyrosine kinase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：FER 酪氨酸激酶

种属: Homo sapiens

同用名: TYK3; PPP1R74; p94-Fer

基因 ID: 2241 | 基因类型: protein coding

关于 FER

Cytogenetic location: 5q21.3 Genomic coordinates (GRCh38): 5:108,747,897-109,196,841 (from NCBI)

This gene has 9 transcripts (splice variants), 222 orthologues and 32 paralogues. Ubiquitous expression in thyroid (RPKM 2.8), testis (RPKM 2.2) and 25 other tissues.

功能概要

该基因编码的蛋白质是非跨膜受体酪氨酸激酶 FPS/FES 家族的成员。它调节细胞间粘附并通过生长因子受体介导从细胞表面到细胞骨架的信号传导。可变剪接导致多个转录本变体。已在 X 染色体上鉴定出一个相关的假基因。[RefSeq 提供，2015 年 4 月]

The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane Receptor Tyrosine Kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the Cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Apr 2015]

FER 基因产物(4)

mRNA Protein Name
NM_001308028.2 NP_001294957.1 tyrosine-protein kinase Fer isoform b
NM_001308031.2 NP_001294960.1 tyrosine-protein kinase Fer isoform c
NM_001308038.2 NP_001294967.1 tyrosine-protein kinase Fer isoform d
NM_005246.4 NP_005237.2 tyrosine-protein kinase Fer isoform a

FER 蛋白结构

FCH

FCH: Fes/CIP4, and EFC/F-BAR homology domain (1 - 92)

SH2

SH2: SH2 domain (460 - 531)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (565 - 814)

  • 0
  • 200
  • 400
  • 600
  • 822 a.a.
蛋白主名 其他名称

tyrosine-protein kinase Fer

feline encephalitis virus-related kinase FER

FER 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FER P16591 CDC37 Homo sapiens Q16543
Lumier
25036637
种属内
FER P16591 CDC37 Homo sapiens Q16543
Pull Down
32707033
种属内
FER P16591 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
种属间
FER P16591 Bcat Gallus gallus O42486
CoIP
15226396
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category
Trichothiodystrophy 5, Nonphotosensitive

TTD5

Nonphotosensitive Trichothiodystrophy 5

Trichothiodystrophy 5, Non-Photosensitive
Ceroid Lipofuscinosis, Neuronal, 6a

Neuronal Ceroid Lipofuscinosis 6

CLN6

Vlincl

Cln6 Disease

Ceroid Lipofuscinosis, Neuronal, 6

Late-Infantile Neuronal Ceroid Lipofuscinosis

CLN6A

Neuronal Ceroid Lipofuscinosis, Late Infantile, Variant

Neuronal Ceroid Lipofuscinosis 6a

Neuronal Ceroid Lipofuscinosis 6 Variable Age Of Onset

Cln6 Disease, Adult Kufs Type A

Cln6 Disease, Late Infantile

Neuronal Ceroid Lipofuscinosis, Gypsy/Indian Early Juvenile Variant

Ceroid Lipofuscinosis Neuronal 6

Cln6-Related Neuronal Ceroid Lipofuscinosis

Late Infantile Neuronal Ceroid Lipofuscinosis

Jansky-Bielschowsky Disease

Lincl

Late Infantile Ncl

Neuronal Ceroid Lipofuscinosis 6 With Variable Age At Onset

Variant Late-Onset Infantile Neuronal Ceroid Lipofuscinosis

Ceroid Lipofuscinosis, Neuronal, Late Infantile, Variant

Lipofuscinosis, Ceroid, Neuronal, Type 6

Ceroid Lipofuscinosis, Neuronal, 5
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-122844 Ifebemtinib Inhibitor 99.86% Phase 2
Pre-clinical Phase
生物活性分子 (17)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100579 Ferrostatin-1 Inhibitor 99.96% 否
HY-123919 TL13-112 Inhibitor 98.15% 否
HY-148063 DB0614 98.80% 否
HY-112097 E260 Inhibitor 99.05% 否
HY-128576 DS21360717 99.80% 否
HY-122582 TL13-12 Inhibitor 98.06% 否
HY-148061 DB1113 99.28% 否
HY-160971 Ribonucleic Acid, Transfer from Brewing yeast Inhibitor ≥99.0% 否
HY-116087 SRS11-92 Inhibitor 99.92% 否
HY-76542A 5,6-trans-Vitamin D2 98.77% 否
HY-136194 TL13-22 Inhibitor 99.71% 否
HY-10338A Foretinib phosphate Inhibitor / 否
HY-136195 TL13-110 Inhibitor / 否
HY-156066 Ferrostatin-1 diyne Inhibitor / 否
HY-161731 DS08701581 Inhibitor / 否
HY-RS04862 FER Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04863 FER1L6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris FER NCBI NCBI:403754
Felis catus FER NCBI NCBI:101094235
Macaca fascicularis FER NCBI NCBI:102143808
Canis lupus familiaris FER NCBI
Mus musculus FER NCBI NCBI:14158
Susscrofa domestica FER NCBI
Rattus norvegicus FER NCBI NCBI:301737
Macaca mulatta FER NCBI NCBI:711220
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