1. Gene
  2. Map4k3 - mitogen-activated protein kinase kinase kinase kinase 3 Gene

Map4k3 - mitogen-activated protein kinase kinase kinase kinase 3 Gene

中文名称:丝裂原活化蛋白激酶激酶激酶激酶 3

种属: Mus musculus

同用名: Glk; MEKKK3; MEKKK 3; MAPKKKK3; RAB8IPL1; 4833416M01Rik; 4833416M07Rik; 9530052P13Rik

基因 ID: 225028 | 基因类型: protein coding

关于 Map4k3

Chromosome 17: 80,887,941-81,035,914 reverse strand.GRCm39:CM001010.3

This gene has 8 transcripts (splice variants), 211 orthologues, 35 paralogues and is associated with 16 phenotypes. Ubiquitous expression in bladder adult (RPKM 16.8), limb E14.5 (RPKM 14.8) and 28 other tissues.

功能概要

预测该基因编码的蛋白可启动 ATP 绑定活动; MAP激酶激酶激酶活性;和 SH3 域绑定活动。预计参与多个过程,包括蛋白质磷酸化;对紫外线的反应;和对肿瘤坏死因子的反应。预测作用于磷酸化上游或内部。以多种结构表达,包括消化系统;脑;泌尿生殖系统;呼吸系统;和感觉器官。与人 MAP4K3(丝裂原活化蛋白激酶激酶 kinase kinase 3)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable ATP binding activity; MAP kinase kinase kinase kinase activity; and SH3 domain binding activity. Predicted to be involved in several processes, including protein phosphorylation; response to UV; and response to tumor necrosis factor. Predicted to act upstream of or within phosphorylation. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Map4k3 基因产物(2)

mRNA Protein Name
NM_001360278.1 NP_001347207.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform 2
NM_001290345.1 NP_001277274.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21983831 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Map4k3 蛋白结构

STKc_MAP4K3_like

STKc_MAP4K3_like: cd06613 (14 - 272)

CNH

CNH: smart00036 (560 - 873)

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  • 894 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase kinase kinase kinase 3

MAPK/ERK kinase kinase kinase 3

MEK kinase kinase 3

germinal center kinase-related protein kinase

Map4k3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra Map4k3 Q99JP0 Prkcq Mus musculus Q02111
Anti Bait CoIP
21983831
Cross Map4k3 Q99JP0 LCP2 Homo sapiens Q13094
Anti Tag CoIP
21983831
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Map4k3 NCBI NCBI:8491