2. Gene
  3. ATG14 - autophagy related 14 Gene

ATG14 - autophagy related 14 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：自噬相关 14

种属: Homo sapiens

同用名: ATG14L; BARKOR; KIAA0831

基因 ID: 22863 | 基因类型: protein coding

关于 ATG14

Cytogenetic location: 14q22.3 Genomic coordinates (GRCh38): 14:55,366,391-55,411,830 (from NCBI)

This gene has 2 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in bone marrow (RPKM 13.8), testis (RPKM 7.6) and 25 other tissues.

功能概要

启用 GTPase 绑定活动。参与多个过程，包括巨自噬；磷酸化的调节；和对线粒体去极化的反应。在内体上游或内作用于溶酶体运输。位于自噬体和吞噬泡组装位点的膜上。是 omegasome 膜的外在成分和吞噬泡组装位点膜的外在成分。 [由基因组资源联盟提供，2022 年 4 月]

Enables GTPase binding activity. Involved in several processes, including macroautophagy; regulation of phosphorylation; and response to mitochondrial depolarisation. Acts upstream of or within endosome to lysosome transport. Located in autophagosome and phagophore assembly site membrane. Is extrinsic component of omegasome membrane and extrinsic component of phagophore assembly site membrane. [provided by Alliance of Genome Resources, Apr 2022]

ATG14 基因产物(1)

mRNA Protein Name
NM_014924.5 NP_055739.2 beclin 1-associated autophagy-related key regulator
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase binding IPI
IPI: 通过物理相互作用推断
25891078 GOA
enables phosphatidylinositol 3-kinase inhibitor activity IDA
IDA: 通过直接分析推断
21062745 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19050071 GOA
enables protein-membrane adaptor activity IDA
IDA: 通过直接分析推断
20713597 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in autophagosome assembly IDA
IDA: 通过直接分析推断
20713597 GOA
involved in autophagosome assembly IMP
IMP: 通过突变表型推断
19270696 GOA
involved in autophagosome maturation IDA
IDA: 通过直接分析推断
10625637 GOA
involved in autophagosome membrane docking IDA
IDA: 通过直接分析推断
25686604 GOA
involved in cellular response to starvation IMP
IMP: 通过突变表型推断
23878393 GOA
involved in early endosome to late endosome transport IDA
IDA: 通过直接分析推断
14617358 GOA
acts upstream of or within endosome to lysosome transport IGI
IGI: 通过遗传相互作用推断
22797916 GOA
involved in macroautophagy IMP
IMP: 通过突变表型推断
23878393 GOA
involved in mitophagy IMP
IMP: 通过突变表型推断
23878393 GOA
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
21062745 GOA
involved in phosphatidylinositol-3-phosphate biosynthetic process IDA
IDA: 通过直接分析推断
8999962 GOA
involved in post-transcriptional regulation of gene expression IMP
IMP: 通过突变表型推断
23878393 GOA
involved in regulation of macroautophagy IDA
IDA: 通过直接分析推断
10625637 GOA
involved in regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
23878393 GOA
involved in response to mitochondrial depolarisation IMP
IMP: 通过突变表型推断
23878393 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in autophagosome IDA
IDA: 通过直接分析推断
19270696 GOA
located in extrinsic component of omegasome membrane IDA
IDA: 通过直接分析推断
21518905 GOA
located in extrinsic component of phagophore assembly site membrane IDA
IDA: 通过直接分析推断
21518905 GOA
is active in phagophore assembly site IDA
IDA: 通过直接分析推断
20713597 GOA
located in phagophore assembly site membrane IDA
IDA: 通过直接分析推断
19270696 GOA
part of phosphatidylinositol 3-kinase complex, class III IPI
IPI: 通过物理相互作用推断
25490155 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ATG14 蛋白结构

Atg14

Atg14: Vacuolar sorting 38 and autophagy-related subunit 14 (42 - 386)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 492 a.a.
蛋白主名 其他名称

beclin 1-associated autophagy-related key regulator

ATG14 autophagy related 14 homolog

ATG14 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
35271311
种属内
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
Anti Bait CoIP
23332761
种属内
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
Pull Down
25490155
种属内
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
19050071
种属内
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
20562859
种属内
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
33961781
种属内
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
22493499
种属内
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
BioID
34524948
种属内
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
28514442
种属内
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
GMS
25490155
种属内
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
EM
25490155
种属内
ATG14 Q6ZNE5 MIS18A Homo sapiens Q9NYP9
Complementation
32296183
种属内
ATG14 Q6ZNE5 MIS18A Homo sapiens Q9NYP9
Y2H Array
32296183
种属内
ATG14 Q6ZNE5 MIS18A Homo sapiens Q9NYP9
Y2H Prey Pooling
32296183
种属内
ATG14 Q6ZNE5 MIS18A Homo sapiens Q9NYP9
Validated Y2H
32296183
种属内
ATG14 Q6ZNE5 FSD2 Homo sapiens A1L4K1
Y2H Prey Pooling
32296183
种属内
ATG14 Q6ZNE5 FSD2 Homo sapiens A1L4K1
Y2H Array
32296183
种属内
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Anti Tag CoIP
33961781
种属内
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
BioID
34524948
种属内
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Pull Down
21062745
种属内
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Anti Bait CoIP
23332761
种属内
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Anti Tag CoIP
28514442
种属内
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Anti Tag CoIP
22493499
种属内
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Pull Down
25490155
种属内
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Anti Tag CoIP
19050071
种属内
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
GMS
25490155
种属内
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
EM
25490155
种属内
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Y2H
22081109
种属内
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Y2H Prey Pooling
32296183
种属内
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Y2H Array
32296183
种属内
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Anti Tag CoIP
20562859
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ATG14 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71576 ATG14 Protein, Human (Myc, His) Q6ZNE5-1 (M1-R492) ≥95%

关联疾病

疾病名称 别名
Neurodegeneration With Brain Iron Accumulation

Nbia

Neurodegeneration With Brain Iron Accumulation Disorders

Neurodegeneration, With Brain Iron Accumulation
Liver Carcinoma In Situ

Carcinoma In Situ Of Liver And Biliary System

Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts
Vici Syndrome

Absent Corpus Callosum Cataract Immunodeficiency

VICIS

Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation, And Absent Corpus Callosum

Dionisi Vici Sabetta Gambarara Syndrome

Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation And Absent Corpus Callosum

Corpus Callosum Agenesis-Cataract-Immunodeficiency Syndrome

Dionisi-Vici-Sabetta-Gambarara Syndrome

Immunodeficiency With Cleft Lip/Palate Cataract Hypopigmentation And Absent Corpus Callosum
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-145752 HaloPROTAC-E Inhibitor 99.62% 否
HY-156237 Beclin1-ATG14L interaction inhibitor 1 Inhibitor 99.88% 否
HY-RS01142 ATG14 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ATG14 VGNC VGNC:26252
Macaca mulatta ATG14 VGNC VGNC:107996
Canis familiaris ATG14 VGNC VGNC:38218
Rattus norvegicus ATG14 RGD RGD:1304610
Felis catus ATG14 VGNC VGNC:59997
Mus musculus ATG14 MGD MGI:1261775
Others ATG14 NCBI
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