1. Gene
  2. HABP4 - hyaluronan binding protein 4 Gene

HABP4 - hyaluronan binding protein 4 Gene

中文名称:透明质酸结合蛋白 4

种属: Homo sapiens

同用名: IHABP4; IHABP-4; Ki-1/57; SERBP1L

基因 ID: 22927 | 基因类型: protein coding

关于 HABP4

Cytogenetic location: 9q22.32 Genomic coordinates (GRCh38): 9:96,450,102-96,491,336 (from NCBI)

This gene has 3 transcripts (splice variants), 183 orthologues and 1 paralogue. Broad expression in brain (RPKM 24.4), testis (RPKM 16.9) and 22 other tissues.

功能概要

启用 SUMO 绑定活动。参与 PML 团体组织; DNA 结合活性的负调节;和基因表达的正调控。位于多种细胞成分中,包括高尔基体;细胞质应激颗粒;和核腔。 [由基因组资源联盟提供,2022 年 4 月]

Enables SUMO binding activity. Involved in PML body organization; negative regulation of DNA binding activity; and positive regulation of gene expression. Located in several cellular components, including Golgi apparatus; cytoplasmic stress granule; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

HABP4 基因产物(1)

mRNA Protein Name
NM_014282.4 NP_055097.2 intracellular hyaluronan-binding protein 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SUMO binding IDA
IDA: 通过直接分析推断
28695742 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15862299 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in PML body organization IDA
IDA: 通过直接分析推断
28695742 GOA
involved in negative regulation of DNA binding IDA
IDA: 通过直接分析推断
15862299 GOA
involved in positive regulation of RNA splicing IMP
IMP: 通过突变表型推断
19523114 GOA
involved in positive regulation of translational initiation IMP
IMP: 通过突变表型推断
21771594 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Cajal body IDA
IDA: 通过直接分析推断
19523114 GOA
located in Gemini of coiled bodies IDA
IDA: 通过直接分析推断
19523114 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
16879614 GOA
located in cytoplasmic stress granule IDA
IDA: 通过直接分析推断
21771594 GOA
located in nuclear speck IDA
IDA: 通过直接分析推断
19523114 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
19523114 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16879614 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

HABP4 蛋白结构

HABP4_PAI-RBP1

HABP4_PAI-RBP1: Hyaluronan / mRNA binding family (212 - 316)

  • 0
  • 100
  • 200
  • 300
  • 413 a.a.
蛋白主名 其他名称

intracellular hyaluronan-binding protein 4

chromodomain helicase DNA binding protein 3 interacting protein

HABP4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HABP4 Q5JVS0 SRSF9 Homo sapiens Q13242
Pull Down
19523114
种属内
HABP4 Q5JVS0 PRMT1 Homo sapiens Q99873
Y2H Pooling
16169070
种属内
HABP4 Q5JVS0 PRMT1 Homo sapiens Q99873
Pull Down
16169070
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Canis familiaris HABP4 VGNC VGNC:41581
Bos taurus HABP4 VGNC VGNC:29736
Rattus norvegicus HABP4 RGD RGD:1306486
Macaca mulatta HABP4 VGNC VGNC:73183
Mus musculus HABP4 MGD MGI:1891713
Felis catus HABP4 VGNC VGNC:62745