SARM1 - sterile alpha and TIR motif containing 1 Gene

中文名称：含无菌 alpha 和 TIR 基序 1

种属: Homo sapiens

同用名: SARM; HsTIR; SAMD2; hSARM1; MyD88-5

基因 ID: 23098 | 基因类型: protein coding

关于 SARM1

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,371,694-28,404,049 (from NCBI)

This gene has 8 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in duodenum (RPKM 30.5), small intestine (RPKM 14.6) and 23 other tissues.

功能概要

启用 NAD+ 核苷酸酶、环状 ADP-核糖生成和相同的蛋白质结合活性。参与 NAD 分解代谢过程；神经元死亡的正调节；和对轴突损伤的反应。位于线粒体中。 [由基因组资源联盟提供，2022 年 4 月]

Enables NAD+ nucleotidase, cyclic ADP-ribose generating and identical protein binding activity. Involved in NAD catabolic process; positive regulation of neuron death; and response to axon injury. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

SARM1 基因产物(1)

mRNA	Protein	Name
NM_015077.4	NP_055892.2	NAD(+) hydrolase SARM1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables NAD+ nucleosidase activity	IDA IDA: 通过直接分析推断	28334607	GOA
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IDA IDA: 通过直接分析推断	28334607	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	31439792	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17258210	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in NAD catabolic process	IDA IDA: 通过直接分析推断	25908823	GOA
involved in response to axon injury	IDA IDA: 通过直接分析推断	25908823	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in mitochondrion	IDA IDA: 通过直接分析推断	22145856	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SARM1 蛋白结构

SAM_2

TIR_2

0
200
400
600
690 a.a.

蛋白主名

其他名称

NAD(+) hydrolase SARM1

NADP(+) hydrolase SARM1

SARM1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SARM1	Q6SZW1	MYD88	Homo sapiens	Q99836	Pull Down	26592460
种属内	SARM1	Q6SZW1	MYD88	Homo sapiens	Q99836	Confocal	26592460
种属内	SARM1	Q6SZW1	TICAM2	Homo sapiens	Q86XR7	Pull Down	26592460

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Folate Malabsorption, Hereditary

Hereditary Folate Malabsorption	Congenital Defect Of Folate Absorption
Congenital Folate Malabsorption	Folic Acid Transport Defect
HFM

Wallerian Degeneration

Wallerian Degeneration Of The Pyramidal Tract

Bullous Retinoschisis

Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2	CMT2E
CMT2S	CMT2Y
Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Disease Type 2y
Charcot-Marie-Tooth Disease Axonal Type 2s	Charcot-Marie-Tooth Disease, Axonal, Type 2s
Charcot-Marie-Tooth Disease, Type 2e	Hereditary Motor And Sensory Neuropathy Type 2
Charcot-Marie-Tooth Neuropathy, Type 2s	Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s
Charcot-Marie-Tooth Disease, Axonal, Type 2y	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y
Charcot-Marie-Tooth Neuropathy, Type 2y	Charcot-Marie-Tooth Disease, Type 2y
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Neuropathy Type 2e
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation	Cmt2 Due To Vcp Mutation
Charcot-Marie-Tooth Disease Type 2s	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease	Cmt2
Charcot-Marie-Tooth Neuropathy, Type 2e	Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type
Hereditary Motor And Sensory Neuropathy Okinawa Type	Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y
Charcot-Marie-Tooth Neuropathy Type 2y	Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s
Charcot-Marie-Tooth Neuropathy Type 2s	Charcot-Marie-Tooth Type 2
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y	Charcot-Marie-Tooth Disease 2e
Charcot-Marie-Tooth Disease Axonal Type 2e	Charcot-Marie-Tooth Disease Neuronal Type 2e
Charcot-Marie-Tooth Disease 2s	Charcot-Marie-Tooth Neuropathy Axonal Type 2s
Charcot-Marie-Tooth Disease 2y	Charcot-Marie-Tooth Disease, Type 2
Hereditary Motor And Sensory-Neuropathy Type Ii

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-B0985	Phenazopyridine hydrochloride	Antagonist	99.84%	否
HY-B0985A	Phenazopyridine	Antagonist	99.93%	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-129522	Sulfo-ara-F-NMN	Activator	99.36%	否
HY-W021879	DSRM-3716	Inhibitor	99.86%	否
HY-145917	SARM1-IN-2	Inhibitor	99.34%	否
HY-Z0816	Dehydronitrosonisoldipine	Antagonist	≥98.0%	否
HY-112257	S-23	Modulator	99.93%	否
HY-161918	SARM1-IN-3	Inhibitor	/	否
HY-RS12446	SARM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W008341	5-Chloroisoquinoline	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	SARM1	VGNC	VGNC:104648
Rattus norvegicus	SARM1	RGD	RGD:1310078
Mus musculus	SARM1	MGD	MGI:2136419
Bos taurus	SARM1	VGNC	VGNC:34290
Canis familiaris	SARM1	VGNC	VGNC:45868
Felis catus	SARM1	VGNC	VGNC:64875
Others	SARM1	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SARM1 - sterile alpha and TIR motif containing 1 Gene

关于 SARM1

功能概要

SARM1 基因产物(1)

SARM1 蛋白结构

SARM1 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

SARM1 - sterile alpha and TIR motif containing 1 Gene

关于 SARM1

功能概要

SARM1 基因产物(1)

SARM1 蛋白结构

SARM1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z