1. Gene
  2. HIC2 - HIC ZBTB transcriptional repressor 2 Gene

HIC2 - HIC ZBTB transcriptional repressor 2 Gene

中文名称:HIC ZBTB 转录抑制因子 2

种属: Homo sapiens

同用名: HRG22; ZBTB30; ZNF907

基因 ID: 23119 | 基因类型: protein coding

关于 HIC2

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:21,417,371-21,451,463 (from NCBI)

This gene has 3 transcripts (splice variants), 187 orthologues and 36 paralogues. Broad expression in placenta (RPKM 3.4), testis (RPKM 2.9) and 25 other tissues.

功能概要

启用蛋白质 C 末端结合活性。预计参与 RNA 聚合酶 II 的转录调控。位于核质中。 [由基因组资源联盟提供,2022 年 4 月]

Enables protein C-terminus binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

HIC2 基因产物(1)

mRNA Protein Name
NM_015094.3 NP_055909.2 hypermethylated in cancer 2 protein
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12052894 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
11554746 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

HIC2 蛋白结构

BTB

BTB: BTB/POZ domain (36 - 141)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (447 - 464)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (505 - 527)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (533 - 555)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (576 - 599)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 615 a.a.
蛋白主名 其他名称

hypermethylated in cancer 2 protein

HIC1-related gene on chromosome 22 protein

HIC2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HIC2 Q96JB3 CEP70 Homo sapiens Q8NHQ1 32296183
种属内
HIC2 Q96JB3 CEP70 Homo sapiens Q8NHQ1 32296183
种属内
HIC2 Q96JB3 ZBTB8A Homo sapiens Q96BR9 32296183
种属内
HIC2 Q96JB3 ZBTB8A Homo sapiens Q96BR9 32296183
种属内
HIC2 Q96JB3 ZBTB8A Homo sapiens Q96BR9 32296183
种属内
HIC2 Q96JB3 EHMT2 Homo sapiens Q96KQ7 32296183
种属内
HIC2 Q96JB3 EHMT2 Homo sapiens Q96KQ7 32296183
种属内
HIC2 Q96JB3 EHMT2 Homo sapiens Q96KQ7 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Orofaciodigital Syndrome X

OFD10

Orofaciodigital Syndrome With Fibular Aplasia

Oral-Facial-Digital Syndrome With Fibular Aplasia

Ofds X

Oral-Facial-Digital Syndrome, Type X

Orofaciodigital Syndrome 10

Ofd Syndrome 10

Ofds 10

Oral Facial Digital Syndrome 10

Oral Facial Digital Syndrome Type 10

Oral-Facial-Digital Syndrome 10

Orofaciodigital Syndrome Type Figuera

Orofaciodigital Syndrome Type 10

Figuera Syndrome

Oral-Facial-Digital Syndrome Type 10

Digeorge Syndrome

Chromosome 22q11.2 Deletion Syndrome

DGS

Hypoplasia Of Thymus And Parathyroids

Third And Fourth Pharyngeal Pouch Syndrome

22q11.2 Deletion Syndrome

Digeorge Sequence

Digeorge'S Syndrome

Pharyngeal Pouch Syndrome

Di-George Syndrome

Shprintzen Syndrome

Simpson-Golabi-Behmel Syndrome, Type 1

Simpson-Golabi-Behmel Syndrome Type 1

Simpson-Golabi-Behmel Syndrome

SGBS1

Golabi-Rosen Syndrome

Simpson Dysmorphia Syndrome

Sgbs

Bulldog Syndrome

Dgsx

Sdys

Dysplasia Gigantism Syndrome, X-Linked

X-Linked Dysplasia Gigantism Syndrome

Dgsx Golabi-Rosen Syndrome

Sara Angers Syndrome

Sgb Syndrome

Mental Retardation-Overgrowth Syndrome

Simpson Dysplasia Syndrome

Simpson Syndrome

Simpson-Golabi-Behmel Syndrome 1

Dysplasia Gigantism Syndrome X-Linked

Van Den Ende-Gupta Syndrome

VDEGS

Blepharophimosis, Arachnodactyly, And Congenital Contractures

Marden-Walker-Like Syndrome

Marden-Walker-Like Syndrome Without Psychomotor Retardation

Marden Walker Like Syndrome

Marden-Walker-Like Syndrome Without Psychmotor Retardation

Van Den Ende Gupta Syndrome

Marden Walker Like Syndrome Without Psychomotor Retardation

Blepharophimosis Arachnodactyly And Congenital Contractures

Velocardiofacial Syndrome

Shprintzen Syndrome

VCFS

Chromosome 22q11.2 Deletion Syndrome

Vcf Syndrome

Shprintzen Vcf Syndrome

Vcf-Velocardiofacial Syndrome

Velo-Cardio-Facial Syndrome

Digeorge Syndrome

22q11 Deletion Syndrome

Conotruncal Anomaly Face Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta HIC2 VGNC VGNC:82156
Bos taurus HIC2 VGNC VGNC:29846
Mus musculus HIC2 MGD MGI:1929869
Canis familiaris HIC2 VGNC VGNC:41684
Rattus norvegicus HIC2 RGD RGD:1305338
Felis catus HIC2 VGNC VGNC:62812