SIK2 - salt inducible kinase 2 Gene

中文名称：盐诱导激酶 2

种属: Homo sapiens

同用名: QIK; SIK-2; SNF1LK2; LOH11CR1I

基因 ID: 23235 | 基因类型: protein coding

关于 SIK2

Cytogenetic location: 11q23.1 Genomic coordinates (GRCh38): 11:111,602,449-111,730,855 (from NCBI)

This gene has 2 transcripts (splice variants), 231 orthologues and 17 paralogues. Ubiquitous expression in fat (RPKM 24.2), brain (RPKM 10.3) and 25 other tissues.

功能概要

启用 ATP 绑定活动；镁离子结合活性；和蛋白丝氨酸/苏氨酸激酶活性。参与细胞内信号转导和蛋白质自身磷酸化。预测位于核内。预计在细胞质中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction and protein autophosphorylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SIK2 基因产物(2)

mRNA	Protein	Name
XM_017017417.2	XP_016872906.1	serine/threonine-protein kinase SIK2 isoform X1
NM_015191.3	NP_056006.1	serine/threonine-protein kinase SIK2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP binding	IDA IDA: 通过直接分析推断	14976552	GOA
enables magnesium ion binding	IDA IDA: 通过直接分析推断	14976552	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16306228	GOA
enables protein serine kinase activity	IDA IDA: 通过直接分析推断	24129571	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	14976552	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in intracellular signal transduction	IDA IDA: 通过直接分析推断	14976552	GOA
involved in protein autophosphorylation	IDA IDA: 通过直接分析推断	18348280	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	14976552	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	24129571	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SIK2 蛋白结构

Pkinase

0
200
400
600
800
926 a.a.

蛋白主名

其他名称

serine/threonine-protein kinase SIK2

SNF1-like kinase 2	qin-induced kinase
salt-inducible protein kinase 2	salt-inducible serine/threonine kinase 2
serine/threonine-protein kinase SNF1-like kinase 2

SIK2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SIK2	Q9H0K1	CEP250	Homo sapiens	Q9BV73	Protein Kinase Assay	20708153
种属内	SIK2	Q9H0K1	VCP	Homo sapiens	P55072	Y2H Array	32814053
种属内	SIK2	Q9H0K1	VCP	Homo sapiens	P55072	Y2H Pooling	32814053
种属内	SIK2	Q9H0K1	VCP	Homo sapiens	P55072	TAP	16306228
种属内	SIK2	Q9H0K1	VCP	Homo sapiens	P55072	Validated Y2H	32814053
种属内	SIK2	Q9H0K1	GABARAPL2	Homo sapiens	P60520	Y2H Array	25416956
种属内	SIK2	Q9H0K1	GABARAPL2	Homo sapiens	P60520	Y2H Prey Pooling	25416956
种属内	SIK2	Q9H0K1	PIK3R1	Homo sapiens	P27986	Protein Kinase Assay	27478041

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Diabetes Mellitus, Non-Insulin-Dependent	Type 2 Diabetes
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-15776	HG-9-91-01	Inhibitor	99.77%	否
HY-120877	MRT199665	Inhibitor	99.74%	否
HY-120856	ARN-3236	Inhibitor	98.60%	否
HY-157442	GLPG3312	Inhibitor	98.25%	否
HY-148062	RSS0680		98.03%	否
HY-148063	DB0614		98.80%	否
HY-148061	DB1113		99.28%	否
HY-139253	MRIA9	Inhibitor	98.80%	否
HY-163743	SIC-19	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	SIK2	RGD	RGD:1559698
Canis familiaris	SIK2	VGNC	VGNC:53440
Bos taurus	SIK2	VGNC	VGNC:50078
Felis catus	SIK2	VGNC	VGNC:65143
Mus musculus	SIK2	MGD	MGI:2445031
Macaca mulatta	SIK2	VGNC	VGNC:82237

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SIK2 - salt inducible kinase 2 Gene

关于 SIK2

功能概要

SIK2 基因产物(2)

SIK2 蛋白结构

SIK2 蛋白互作信息

关联疾病

直系同源

热门区域

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SIK2 - salt inducible kinase 2 Gene

关于 SIK2

功能概要

SIK2 基因产物(2)

SIK2 蛋白结构

SIK2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z