2. Gene
  3. COTL1 - coactosin like F-actin binding protein 1 Gene

COTL1 - coactosin like F-actin binding protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肌动蛋白样 F-肌动蛋白结合蛋白 1

种属: Homo sapiens

同用名: CLP

基因 ID: 23406 | 基因类型: protein coding

关于 COTL1

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:84,565,596-84,618,078 (from NCBI)

This gene has 6 transcripts (splice variants), 197 orthologues and 4 paralogues. Broad expression in lymph node (RPKM 178.3), appendix (RPKM 165.6) and 20 other tissues.

功能概要

该基因编码调节肌动蛋白细胞骨架的众多肌动蛋白结合蛋白之一。这种蛋白质结合 F-肌动蛋白，还与 5-脂氧合酶相互作用，5-脂氧合酶是白三烯生物合成中的第一个定向酶。虽然该基因已被报道映射到 Smith-Magenis 综合征区域的 17 号染色体，但该基因的最佳比对是与 16 号染色体。Smith-Magenis 综合征区域是两个相关假基因的位点。[RefSeq 提供，2008 年 7 月]

This gene encodes one of the numerous actin-binding proteins which regulate the actin Cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed Enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]

COTL1 基因产物(1)

mRNA Protein Name
NM_021149.5 NP_066972.1 coactosin-like protein
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin binding IDA
IDA: 通过直接分析推断
11583571 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
11297527 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11297527 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

COTL1 蛋白结构

Cofilin_ADF

Cofilin_ADF: Cofilin/tropomyosin-type actin-binding protein (9 - 129)

  • 0
  • 100
  • 142 a.a.
蛋白主名 其他名称

coactosin-like protein

coactosin-like 1

COTL1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
COTL1 Q14019 PDE6H Homo sapiens Q13956
Y2H Array
25416956
种属内
COTL1 Q14019 PDE6H Homo sapiens Q13956
Y2H Prey Pooling
25416956
种属内
COTL1 Q14019 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
种属内
COTL1 Q14019 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
种属内
COTL1 Q14019 ALOX5 Homo sapiens P09917
Pull Down
16924104
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Clivus Chordoma

Chordoma Of Clivus
Churg-Strauss Syndrome

Eosinophilic Granulomatosis With Polyangiitis

Allergic Granulomatous Angiitis

Churg-Strauss Vasculitis

Allergic Angiitis

Egpa

Granulomatous Allergic Angiitis

Allergic Granulomatosis Angiitis

Allergic Angiitis And Granulomatosis

Allergic Granulomatosis

Allergic Granulomatous And Angiitis

Css
Smith-Magenis Syndrome

SMS

Chromosome 17p11.2 Deletion Syndrome

17p11.2 Microdeletion Syndrome

17p11.2 Monosomy

Chromosome 17p Deletion Syndrome

Del(17)

P11.2

17p- Syndrome

Deletion 17p Syndrome

Partial Monosomy 17p
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03055 COTL1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus COTL1 MGD MGI:1919292
Rattus norvegicus COTL1 RGD RGD:1305498
Macaca mulatta COTL1 VGNC VGNC:71434
Canis familiaris COTL1 VGNC VGNC:39532
Bos taurus COTL1 VGNC VGNC:27626
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