ICMT - isoprenylcysteine carboxyl methyltransferase Gene

中文名称：异戊二烯半胱氨酸羧甲基转移酶

种属: Homo sapiens

同用名: PCMT; PPMT; PCCMT; HSTE14; MST098; MSTP098

基因 ID: 23463 | 基因类型: protein coding

关于 ICMT

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,221,193-6,235,964 (from NCBI)

This gene has 4 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in kidney (RPKM 21.7), placenta (RPKM 18.3) and 25 other tissues.

功能概要

该基因编码三种酶中的第三种，这些酶在翻译后修饰某些蛋白质中异戊二烯化的 C 末端半胱氨酸残基，并将这些蛋白质靶向细胞膜。该酶定位于内质网。选择性剪接可能会导致其他转录本变体，但这些转录本的生物学有效性尚未确定。[RefSeq 提供，2008 年 7 月]

This gene encodes the third of three Enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This Enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in Other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]

ICMT 基因产物(1)

mRNA	Protein	Name
NM_012405.4	NP_036537.1	protein-S-isoprenylcysteine O-methyltransferase

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	IDA IDA: 通过直接分析推断	9614111	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	9614111	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ICMT 蛋白结构

ICMT

0
100
200
284 a.a.

蛋白主名

其他名称

protein-S-isoprenylcysteine O-methyltransferase

prenylated protein carboxyl methyltransferase

ICMT 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ICMT	O60725	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
种属内	ICMT	O60725	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
种属内	ICMT	O60725	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
种属内	ICMT	O60725	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
种属内	ICMT	O60725	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
种属内	ICMT	O60725	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
种属内	ICMT	O60725	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
种属内	ICMT	O60725	KCNJ6	Homo sapiens	P48051	Validated Y2H	32296183
种属内	ICMT	O60725	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
种属内	ICMT	O60725	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
种属内	ICMT	O60725	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
种属内	ICMT	O60725	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
种属内	ICMT	O60725	MUC1	Homo sapiens	P15941-11	Validated Y2H	32296183
种属内	ICMT	O60725	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
种属内	ICMT	O60725	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
种属内	ICMT	O60725	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Prey Pooling	32296183
种属内	ICMT	O60725	RNF19B	Homo sapiens	Q6ZMZ0	Validated Y2H	32296183
种属内	ICMT	O60725	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Array	32296183
种属内	ICMT	O60725	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
种属内	ICMT	O60725	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
种属内	ICMT	O60725	PDZK1IP1	Homo sapiens	Q13113	Validated Y2H	32296183
种属内	ICMT	O60725	TRIM32	Homo sapiens	Q13049	Y2H Prey Pooling	32296183
种属内	ICMT	O60725	TRIM32	Homo sapiens	Q13049	Validated Y2H	32296183
种属内	ICMT	O60725	TRIM32	Homo sapiens	Q13049	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hyperhomocysteinemia

Familial Partial Lipodystrophy

Lipodystrophy, Familial Partial	Fpld
Kobberling-Dunnigan Syndrome	Dunnigan Syndrome
Koberling-Dunnigan Syndrome	Dunnigan-Kobberling Syndrome
Fpl	Familial Partial Lipodystrophy, Type 2

Hallermann-Streiff Syndrome

Francois Dyscephalic Syndrome	HSS
Hallermann'S Syndrome	Oculomandibulofacial Syndrome
Hallerman - Streiff Syndrome	François Dyscephalic Syndrome
Hallermann Streiff Francois Syndrome	Hallermann Streiff Syndrome

Emery-Dreifuss Muscular Dystrophy 2, Autosomal Dominant

EDMD2	Autosomal Dominant Emery-Dreifuss Muscular Dystrophy
Emd2	Emery-Dreifuss Muscular Dystrophy, Autosomal Dominant
Scapuloilioperoneal Atrophy With Cardiopathy	Muscular Dystrophy With Early Contractures And Cardiomyopathy, Autosomal Dominant
Hauptmann-Thannhauser Muscular Dystrophy	Cardiomyopathy, Dilated, With Quadriceps Myopathy
Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 2	Muscular Dystrophy, Limb-Girdle, Type 1b
Muscular Dystrophy, Limb-Girdle, Type 1b, Formerly	Lgmd1b, Formerly
Muscular Dystrophy, Proximal, Type 1b, Formerly	Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1b
Lgmd1b	Limb-Girdle Muscular Dystrophy 1b
Muscular Dystrophy, Proximal, Type 1b	Muscular Dystrophy With Early Contractures And Cardiomyopathy Autosomal Dominant

Hutchinson-Gilford Progeria Syndrome

Progeria	HGPS
Hutchinson-Gilford Syndrome	Hutchinson-Gilford Progeria
Hutchinson Gilford Syndrome	Hutchinson Gilford Progeria Syndrome
Hutchinson-Gilford Disease	Progeria Of Childhood
Hutchinson-Gilford-Progeria Syndrome

Cardiomyopathy, Dilated, 1a

Dilated Cardiomyopathy 1a	Cdcd1
CMD1A	Cardiomyopathy, Familial Idiopathic
Familial Dilated Cardiomyopathy With Conduction Defect Due To Lmna Mutation	Cardiomyopathy, Dilated, With Conduction Defect 1
Cardiomyopathy, Idiopathic Dilated	Cardiomyopathy, Congestive
Dilated Cardiomyopathy With Conduction Defect 1	Cardiomyopathy Dilated With Conduction Defect Type 1
Cardiomyopathy, Dilated 1a	Cardiomyopathy Dilated With Conduction Defect 1
Cardiomyopathy, Dilated, Type 1a

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase

生物活性分子 (66)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-16160	Cysmethynil		99.87%	否
HY-157103	ICMT-IN-34	Inhibitor	/	否
HY-155436	ICMT-IN-33	Inhibitor	/	否
HY-155431	ICMT-IN-28	Inhibitor	/	否
HY-157097	ICMT-IN-10	Inhibitor	/	否
HY-155428	ICMT-IN-22	Inhibitor	/	否
HY-155429	ICMT-IN-24	Inhibitor	/	否
HY-155434	ICMT-IN-31	Inhibitor	/	否
HY-157115	ICMT-IN-47	Inhibitor	/	否
HY-155427	ICMT-IN-20	Inhibitor	/	否
HY-157094	ICMT-IN-4	Inhibitor	/	否
HY-156500	ICMT-IN-1	Inhibitor	/	否
HY-149705	ICMT-IN-7	Inhibitor	/	否
HY-157116	ICMT-IN-48	Inhibitor	/	否
HY-157101	ICMT-IN-25	Inhibitor	/	否
HY-157092B	(R)-ICMT-IN-3	Inhibitor	/	否
HY-157102	ICMT-IN-26	Inhibitor	/	否
HY-155432	ICMT-IN-29	Inhibitor	/	否
HY-157104	ICMT-IN-36	Inhibitor	/	否
HY-157096	ICMT-IN-8	Inhibitor	/	否
HY-149709	ICMT-IN-35	Inhibitor	/	否
HY-157117	ICMT-IN-49	Inhibitor	/	否
HY-157110	ICMT-IN-42	Inhibitor	/	否
HY-157113	ICMT-IN-45	Inhibitor	/	否
HY-157106	ICMT-IN-38	Inhibitor	/	否
HY-149706	ICMT-IN-12	Inhibitor	/	否
HY-155435	ICMT-IN-32	Inhibitor	/	否
HY-155425	ICMT-IN-17	Inhibitor	/	否
HY-157092	ICMT-IN-3	Inhibitor	/	否
HY-155420	ICMT-IN-9	Inhibitor	/	否
HY-149729	ICMT-IN-53	Inhibitor	/	否
HY-157092A	(S)-ICMT-IN-3	Inhibitor	/	否
HY-157107	ICMT-IN-39	Inhibitor	/	否
HY-157109	ICMT-IN-41	Inhibitor	/	否
HY-155418	ICMT-IN-2	Inhibitor	/	否
HY-155426	ICMT-IN-19	Inhibitor	/	否
HY-155423	ICMT-IN-14	Inhibitor	/	否
HY-157099	ICMT-IN-18	Inhibitor	/	否
HY-157100	ICMT-IN-23	Inhibitor	/	否
HY-157095	ICMT-IN-6	Inhibitor	/	否
HY-155424	ICMT-IN-15	Inhibitor	/	否
HY-157118	ICMT-IN-50	Inhibitor	/	否
HY-157098	ICMT-IN-16	Inhibitor	/	否
HY-155433	ICMT-IN-30	Inhibitor	/	否
HY-157112	ICMT-IN-44	Inhibitor	/	否
HY-157114	ICMT-IN-46	Inhibitor	/	否
HY-155430	ICMT-IN-27	Inhibitor	/	否
HY-149707	ICMT-IN-21	Inhibitor	/	否
HY-157108	ICMT-IN-40	Inhibitor	/	否
HY-155421	ICMT-IN-11	Inhibitor	/	否
HY-157105	ICMT-IN-37	Inhibitor	/	否
HY-157119	ICMT-IN-51	Inhibitor	/	否
HY-157120	ICMT-IN-52	Inhibitor	/	否
HY-149730	ICMT-IN-54	Inhibitor	/	否
HY-155422	ICMT-IN-13	Inhibitor	/	否
HY-155419	ICMT-IN-5	Inhibitor	/	否
HY-157111	ICMT-IN-43	Inhibitor	/	否
HY-149713	J1-1	Inhibitor	/	否
HY-157206	ICMT-IN-55	Inhibitor	/	否
HY-149708	UCM-13207	Inhibitor	99.61%	否
HY-149712	Spermatinamine	Inhibitor	/	否
HY-149715	R1-11	Inhibitor	/	否
HY-149714	J6-3	Inhibitor	/	否
HY-149710	POP-3MB	Inhibitor	/	否
HY-117776	CAY10677	Inhibitor	/	否
HY-149711	Farnesylcysteine	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	ICMT	VGNC	VGNC:67690
Macaca mulatta	ICMT	VGNC	VGNC:73554
Bos taurus	ICMT	VGNC	VGNC:30029
Mus musculus	ICMT	MGD	MGI:1888594
Rattus norvegicus	ICMT	RGD	RGD:621618

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