PLD3 - phospholipase D family member 3 Gene

中文名称：磷脂酶 D 家族成员 3

种属: Homo sapiens

同用名: AD19; HUK4; HU-K4; SCA46

基因 ID: 23646 | 基因类型: protein coding

关于 PLD3

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,348,695-40,378,485 (from NCBI)

This gene has 48 transcripts (splice variants), 198 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 96.3), spleen (RPKM 74.5) and 25 other tissues.

功能概要

该基因编码催化膜磷脂水解的磷脂酶 D (PLD) 家族的成员。编码的蛋白质是一种单程 II 型膜蛋白，包含两个 PLD 磷酸二酯酶结构域。这种蛋白质影响淀粉样蛋白前体蛋白的加工。该基因的突变与阿尔茨海默病风险有关。已发现该基因编码相同蛋白质的可变剪接转录物变体。[RefSeq 提供，2014 年 4 月]

This gene encodes a member of the Phospholipase D (PLD) family of Enzymes that catalyze the hydrolysis of membrane Phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]

PLD3 基因产物(3)

mRNA	Protein	Name
NM_001031696.4	NP_001026866.1	5'-3' exonuclease PLD3
NM_001291311.2	NP_001278240.1	5'-3' exonuclease PLD3
NM_012268.4	NP_036400.2	5'-3' exonuclease PLD3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	20195357	GOA
enables single-stranded DNA 5'-3' DNA exonuclease activity	IDA IDA: 通过直接分析推断	30312375	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in myotube differentiation	IDA IDA: 通过直接分析推断	22428023	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi membrane	IDA IDA: 通过直接分析推断	29368044	GOA
located in early endosome membrane	IDA IDA: 通过直接分析推断	29386126	GOA
located in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	15794758	GOA
located in late endosome membrane	IDA IDA: 通过直接分析推断	29386126	GOA
located in lysosomal lumen	IDA IDA: 通过直接分析推断	30312375	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PLD3 蛋白结构

PLDc_3

0
100
200
300
400
490 a.a.

蛋白主名

其他名称

5'-3' exonuclease PLD3

choline phosphatase 3

PLD3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PLD3	Q8IV08	CNIH3	Homo sapiens	Q8TBE1	Validated Y2H	32296183
Intra	PLD3	Q8IV08	OPRM1	Homo sapiens	P35372-10	Y2H Prey Pooling	32296183
Intra	PLD3	Q8IV08	OPRM1	Homo sapiens	P35372-10	Y2H Array	32296183
Intra	PLD3	Q8IV08	NFKB1	Homo sapiens	P19838	TAP	20195357
Intra	PLD3	Q8IV08	NFKB1	Homo sapiens	P19838	Display Tech	20195357
Intra	PLD3	Q8IV08	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Spinocerebellar Ataxia 46

SCA46	Spinocerebellar Ataxia, 46, Autosomal Dominant, With Sensory Axonal Neuropathy
Spinocerebellar Ataxia Type 46

Acute Hemorrhagic Conjunctivitis

Viral Conjunctivitis	Conjunctivitis, Acute Hemorrhagic
Apollo Disease	Epidemic Hemorrhagic Conjunctivitis
Viral Conjunctiva Disorder	Viral Conjunctivitis Nos

Shipyard Eye

Epidemic Keratoconjunctivitis

Ekc

Conjunctival Folliculosis

Acute Follicular Conjunctivitis

Acute Conjunctivitis

Cerebellar Ataxia Type 41

Sca41

Nephrotic Syndrome, Type 7

Immunoglobulin-Mediated Membranoproliferative Glomerulonephritis	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 7
NPHS7	Nephrotic Syndrome Type 7
Ig-Mediated Membranoproliferative Glomerulonephritis	Ig-Mediated Mpgn
Immunoglobulin-Mediated Mpgn	Nephrotic Syndrome, Type 7, With Membranoproliferative Glomerulonephritis
Hemolytic Uremic Syndrome, Atypical 7	Nephrotic Syndrome Type 7 With Membranoptoliferative Glomerulonephritis
Hemolytic Uremic Syndrome With Dgke Deficiency	Hus With Dgke Deficiency
Hemolytic Uremic Syndrome Atypical 7	AHUS7
Nephrotic Syndrome 7	Nephrotic Syndrome Type 7 With Membranoproliferative Glomerulonephritis

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Spinocerebellar Ataxia, Autosomal Recessive 21

SCAR21	Acute Infantile Liver Failure-Cerebellar Ataxia-Peripheral Sensory Motor Neuropathy Syndrome
Spinocerebellar Ataxia, Autosomal Recessive 21, With Hepatopathy	Cholestasis, Low Ggt, Acute Liver Failure, And Neurodegeneration Syndrome
Calfan	Autosomal Recessive Spinocerebellar Ataxia 21
Autosomal Recessive Spinocerebellar Ataxia 21 With Hepatopathy	Autosomal Recessive Spinocerebellar Ataxia Type 21
Spinocerebellar Ataxia, Autosomal Recessive, 21	Calfan Syndrome

Spinocerebellar Ataxia, Autosomal Recessive 23

SCAR23	Autosomal Recessive Spinocerebellar Ataxia 23
Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Tud Deficiency	Autosomal Recessive Cerebellar Ataxia - Epilepsy - Intellectual Disability Syndrome Due To Tud Deficiency
Spinocerebellar Ataxia Autosomal Recessive Type 23	Spinocerebellar Ataxia, Autosomal Recessive, 23
Ataxia, Spinocerebellar, Autosomal Recessive, Type 23

Cerebellar Ataxia Type 43

Sca43

Spinocerebellar Ataxia, Autosomal Recessive 24

SCAR24	Autosomal Recessive Spinocerebellar Ataxia 24
Spinocerebellar Ataxia, Autosomal Recessive, 24	Ataxia, Spinocerebellar, Autosomal Recessive, Type 24

Inclusion Conjunctivitis

Chlamydial Conjunctivitis	Inclusion Blennorrhoea
Paratrachoma	Adult Inclusion Conjunctivitis
Inclusion Blenorrhea	Conjunctivitis, Inclusion
Neonatal Chlamydial Conjunctivitis	Inclusion Conjunctivitis Of The Adult
Chronic Conjunctivitis Due To Chlamydia Trachomatis	Inclusion Conjunctivitis Due To Chlamydia Trachomatis
Acute Follicular Conjunctivitis, Chlamydial	Adult Chlamydial Keratoconjunctivitis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10672	PLD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PLD3	RGD	RGD:1308248
Canis familiaris	PLD3	VGNC	VGNC:44662
Macaca mulatta	PLD3	VGNC	VGNC:76041
Bos taurus	PLD3	VGNC	VGNC:32997
Mus musculus	PLD3	MGD	MGI:1333782
Felis catus	PLD3	VGNC	VGNC:64213

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PLD3 - phospholipase D family member 3 Gene

关于 PLD3

功能概要

PLD3 基因产物(3)

PLD3 蛋白结构

PLD3 蛋白互作信息

关联疾病

直系同源

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PLD3 - phospholipase D family member 3 Gene

关于 PLD3

功能概要

PLD3 基因产物(3)

PLD3 蛋白结构

PLD3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z