2. Gene
  3. Grm2 - glutamate metabotropic receptor 2 Gene

Grm2 - glutamate metabotropic receptor 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：谷氨酸代谢型受体 2

种属: Rattus norvegicus

基因 ID: 24415 | 基因类型: protein coding

关于 Grm2

Primary_assembly 8: 107,280,099-107,293,146 reverse strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 280 orthologues, 7 paralogues and is associated with 23 phenotypes. Restricted expression toward (RPKM 34.5).

功能概要

该基因编码的蛋白可启动第 II 组代谢型谷氨酸受体活性和支架蛋白结合活性。涉及多个过程，包括对尼古丁的行为反应；谷氨酸分泌；和调节胺运输。在蛋白激酶 B 信号传导的调节上游或调节内起作用。位于星形胶质细胞投影；轴突；和突触前膜。是突触后膜的组成部分。用于研究海洛因依赖。与人类 GRM2（谷氨酸代谢受体 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables group II metabotropic glutamate receptor activity and scaffold protein binding activity. Involved in several processes, including behavioral response to nicotine; glutamate secretion; and regulation of amine transport. Acts upstream of or within regulation of protein kinase B signaling. Located in astrocyte projection; axon; and presynaptic membrane. Is integral component of postsynaptic membrane. Used to study heroin dependence. Orthologous to human GRM2 (glutamate metabotropic receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Grm2 基因产物(1)

mRNA Protein Name
NM_001105711.1 NP_001099181.1 metabotropic glutamate receptor 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables group II metabotropic glutamate receptor activity IMP
IMP: 通过突变表型推断
12837619 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
18555800 RGD
enables scaffold protein binding IPI
IPI: 通过物理相互作用推断
28392297 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in behavioral response to nicotine IMP
IMP: 通过突变表型推断
28700935 RGD
involved in glutamate receptor signaling pathway IMP
IMP: 通过突变表型推断
28392297 RGD
involved in glutamate secretion IDA
IDA: 通过直接分析推断
15993439 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
28392297 RGD
involved in regulation of dopamine secretion IMP
IMP: 通过突变表型推断
30283001 RGD
involved in regulation of glutamate secretion IMP
IMP: 通过突变表型推断
28700935 RGD
involved in regulation of response to drug IMP
IMP: 通过突变表型推断
28700935 RGD
involved in response to cocaine IMP
IMP: 通过突变表型推断
28700935 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in astrocyte projection IDA
IDA: 通过直接分析推断
28392297 RGD
located in axon IDA
IDA: 通过直接分析推断
15993439 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
35511883 RGD
located in presynaptic membrane IDA
IDA: 通过直接分析推断
15993439 RGD
is active in presynaptic membrane IMP
IMP: 通过突变表型推断
35511883 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Grm2 蛋白结构

PBP1_mGluR_groupII

PBP1_mGluR_groupII: cd06375 (25 - 479)

NCD3G

NCD3G: pfam07562 (495 - 545)

7tmC_mGluR2

7tmC_mGluR2: cd15447 (565 - 818)

7tmC_mGluR2

7tmC_mGluR2: cd15447 (565 - 590)

7tmC_mGluR2

7tmC_mGluR2: cd15447 (602 - 623)

7tmC_mGluR2

7tmC_mGluR2: cd15447 (632 - 656)

7tmC_mGluR2

7tmC_mGluR2: cd15447 (678 - 698)

7tmC_mGluR2

7tmC_mGluR2: cd15447 (723 - 749)

7tmC_mGluR2

7tmC_mGluR2: cd15447 (757 - 780)

7tmC_mGluR2

7tmC_mGluR2: cd15447 (787 - 812)

  • 0
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  • 800
  • 872 a.a.
蛋白主名 其他名称

metabotropic glutamate receptor 2

glutamate receptor, metabotropic 2

mGluR2

Grm2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Grm2 P31421 RANBP9 Homo sapiens Q96S59
Pull Down
18555800
种属间
Grm2 P31421 RANBP9 Homo sapiens Q96S59
Y2H
18555800
种属内
Grm2 P31421 Htr2a Rattus norvegicus P14842
Anti Tag CoIP
19590495
种属内
Grm2 P31421 Htr2a Rattus norvegicus P14842
FRET
19590495
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05822 GRM2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05823 Grm2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05824 Grm2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Grm2 NCBI NCBI:2912
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