2. Gene
  3. GRM2 - glutamate metabotropic receptor 2 Gene

GRM2 - glutamate metabotropic receptor 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：谷氨酸代谢型受体 2

种属: Homo sapiens

同用名: GLUR2; mGlu2; GPRC1B; MGLUR2

基因 ID: 2912 | 基因类型: protein coding

关于 GRM2

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:51,707,068-51,718,613 (from NCBI)

This gene has 8 transcripts (splice variants), 277 orthologues and 7 paralogues. Biased expression in testis (RPKM 2.8), brain (RPKM 2.2) and 4 other tissues.

功能概要

L-谷氨酸是中枢神经系统中主要的兴奋性神经递质，可激活离子型和代谢型谷氨酸受体。谷氨酸能神经传递涉及正常大脑功能的大多数方面，并且在许多神经病理学状况下可能受到干扰。代谢型谷氨酸受体是 G 蛋白偶联受体家族，根据序列同源性、推定的信号转导机制和药理学特性将其分为 3 组。 I 组包括 GRM1 和 GRM5，这些受体已显示可激活磷脂酶 C。II 组包括 GRM2 和 GRM3，而 III 组包括 GRM4、GRM6、GRM7 和 GRM8。 II 组和 III 组受体与环 AMP 级联的抑制有关，但它们的激动剂选择性不同。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2017 年 3 月]

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and Metabotropic Glutamate Receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The Metabotropic Glutamate Receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate Phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]

GRM2 基因产物(15)

mRNA Protein Name
XM_011533637.2 XP_011531939.1 metabotropic glutamate receptor 2 isoform X4
XM_047448047.1 XP_047304003.1 metabotropic glutamate receptor 2 isoform X2
XM_047448048.1 XP_047304004.1 metabotropic glutamate receptor 2 isoform X4
NR_146059.2
XM_047448049.1 XP_047304005.1 metabotropic glutamate receptor 2 isoform X4
XM_011533636.2 XP_011531938.1 metabotropic glutamate receptor 2 isoform X3
XM_017006271.2 XP_016861760.1 metabotropic glutamate receptor 2 isoform X1
NM_000839.5 NP_000830.2 metabotropic glutamate receptor 2 isoform a precursor
XM_024453490.2 XP_024309258.1 metabotropic glutamate receptor 2 isoform X7
XM_047448051.1 XP_047304007.1 metabotropic glutamate receptor 2 isoform X4
NM_001349116.2 NP_001336045.1 metabotropic glutamate receptor 2 isoform c
NM_001349117.2 NP_001336046.1 metabotropic glutamate receptor 2 isoform d
XM_011533643.2 XP_011531945.1 metabotropic glutamate receptor 2 isoform X6
XM_047448050.1 XP_047304006.1 metabotropic glutamate receptor 2 isoform X4
XM_011533642.2 XP_011531944.1 metabotropic glutamate receptor 2 isoform X5
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18297054 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GRM2 蛋白结构

ANF_receptor

ANF_receptor: Receptor family ligand binding region (60 - 455)

NCD3G

NCD3G: Nine Cysteines Domain of family 3 GPCR (496 - 546)

7tm_3

7tm_3: 7 transmembrane sweet-taste receptor of 3 GCPR (577 - 817)

  • 0
  • 200
  • 400
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  • 800
  • 872 a.a.
蛋白主名 其他名称

metabotropic glutamate receptor 2

glutamate receptor homolog

glutamate receptor, metabotropic 2

GRM2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GRM2 Q14416 UBQLN1 Homo sapiens Q9UMX0-2
Validated Y2H
25416956
种属内
GRM2 Q14416 NAALADL2 Homo sapiens Q58DX5
Y2H Prey Pooling
25416956
种属内
GRM2 Q14416 SLC30A8 Homo sapiens Q8IWU4
Y2H Prey Pooling
32296183
种属内
GRM2 Q14416 SLC30A8 Homo sapiens Q8IWU4
Y2H Array
32296183
种属内
GRM2 Q14416 SLC30A8 Homo sapiens Q8IWU4
Validated Y2H
32296183
种属内
GRM2 Q14416 TMEM248 Homo sapiens Q9NWD8
Validated Y2H
32296183
种属内
GRM2 Q14416 TMEM248 Homo sapiens Q9NWD8
Y2H Array
32296183
种属内
GRM2 Q14416 TMEM248 Homo sapiens Q9NWD8
Y2H Prey Pooling
32296183
种属内
GRM2 Q14416 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
种属内
GRM2 Q14416 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
种属内
GRM2 Q14416 ACBD5 Homo sapiens Q5T8D3-2
Validated Y2H
32296183
种属内
GRM2 Q14416 ACBD5 Homo sapiens Q5T8D3-2
Y2H Array
32296183
种属内
GRM2 Q14416 ACBD5 Homo sapiens Q5T8D3-2
Y2H Prey Pooling
32296183
种属内
GRM2 Q14416 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
种属内
GRM2 Q14416 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
种属内
GRM2 Q14416 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
种属内
GRM2 Q14416 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
种属内
GRM2 Q14416 STOM Homo sapiens P27105
Y2H Array
32296183
种属内
GRM2 Q14416 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
种属内
GRM2 Q14416 AQP6 Homo sapiens Q13520
Y2H Array
32296183
种属内
GRM2 Q14416 HTR2A Homo sapiens P28223-1
Anti Bait CoIP
18297054
种属内
GRM2 Q14416 HTR2A Homo sapiens P28223-1
Anti Tag CoIP
18297054
种属内
GRM2 Q14416 TSPAN18 Homo sapiens Q8WUV1
Y2H Prey Pooling
32296183
种属内
GRM2 Q14416 TSPAN18 Homo sapiens Q8WUV1
Validated Y2H
32296183
种属内
GRM2 Q14416 TSPAN18 Homo sapiens Q8WUV1
Y2H Array
32296183
种属内
GRM2 Q14416 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
种属内
GRM2 Q14416 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
种属内
GRM2 Q14416 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
种属内
GRM2 Q14416 CLDN9 Homo sapiens O95484
Y2H Array
32296183
种属内
GRM2 Q14416 CLDN9 Homo sapiens O95484
Y2H Prey Pooling
32296183
种属内
GRM2 Q14416 TMEM130 Homo sapiens Q8N3G9
Y2H Prey Pooling
32296183
种属内
GRM2 Q14416 TMEM130 Homo sapiens Q8N3G9
Y2H Array
32296183
种属内
GRM2 Q14416 TMEM130 Homo sapiens Q8N3G9
Validated Y2H
32296183
种属间
GRM2 Q14416 S SARS-CoV-2 P0DTC2
Pull Down
34903715
种属间
GRM2 Q14416 S SARS-CoV-2 P0DTC2
Anti Tag CoIP
34903715
种属内
GRM2 Q14416 DPP4 Homo sapiens P27487
Anti Tag CoIP
34903715
种属内
GRM2 Q14416 DPP4 Homo sapiens P27487
Pull Down
34903715
种属内
GRM2 Q14416 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
种属内
GRM2 Q14416 MFSD14B Homo sapiens Q5SR56
Validated Y2H
32296183
种属内
GRM2 Q14416 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
种属内
GRM2 Q14416 SAR1A Homo sapiens Q9NR31
Validated Y2H
32296183
种属内
GRM2 Q14416 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
种属内
GRM2 Q14416 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
种属内
GRM2 Q14416 MMGT1 Homo sapiens Q8N4V1
Validated Y2H
32296183
种属内
GRM2 Q14416 MMGT1 Homo sapiens Q8N4V1
Y2H Array
32296183
种属内
GRM2 Q14416 MMGT1 Homo sapiens Q8N4V1
Y2H Prey Pooling
32296183
种属内
GRM2 Q14416 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
种属内
GRM2 Q14416 BIK Homo sapiens Q13323
Y2H Array
32296183
种属内
GRM2 Q14416 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
种属内
GRM2 Q14416 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
种属内
GRM2 Q14416 MGST3 Homo sapiens O14880
Y2H Array
32296183
种属内
GRM2 Q14416 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
种属内
GRM2 Q14416 CLDN2 Homo sapiens P57739
Y2H Array
32296183
种属内
GRM2 Q14416 CLDN2 Homo sapiens P57739
Y2H Prey Pooling
32296183
种属内
GRM2 Q14416 ACE2 Homo sapiens Q9BYF1
Anti Tag CoIP
34903715
种属内
GRM2 Q14416 ACE2 Homo sapiens Q9BYF1
Pull Down
34903715
种属内
GRM2 Q14416 CCDC107 Homo sapiens Q8WV48
Validated Y2H
32296183
种属内
GRM2 Q14416 CCDC107 Homo sapiens Q8WV48
Y2H Array
32296183
种属内
GRM2 Q14416 CCDC107 Homo sapiens Q8WV48
Y2H Prey Pooling
32296183
种属内
GRM2 Q14416 SLC38A1 Homo sapiens Q9H2H9
Y2H Prey Pooling
32296183
种属内
GRM2 Q14416 SLC38A1 Homo sapiens Q9H2H9
Validated Y2H
32296183
种属内
GRM2 Q14416 SLC38A1 Homo sapiens Q9H2H9
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

GRM2 抗体

目录号 产品名 应用 反应物种
HY-P83473 Metabotropic Glutamate Receptor 2 Antibody (YA3218) WB, IHC-P Human, Mouse

关联疾病

疾病名称 别名
Impulse Control Disorder

Disruptive, Impulse Control, And Conduct Disorders
Psychotic Disorder

Psychotic Disorders

Mental Or Behavioural Disorder

Psychotic

Mental Disorders
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes
Huntington Disease

Huntington'S Disease

Huntington Chorea

HD

Huntington'S Chorea

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea
Cocaine Dependence
Trichotillomania

TTM

Hair-Pulling Syndrome

Compulsive Hair Plucking

Hair Pulling Disorder
Allergic Urticaria
Mental Depression

Depression

Depressive Disorder
Substance Dependence
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers
Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Generalized Anxiety Disorder

Anxiety Generalized
Tobacco Addiction

Nicotine Dependence

Tobacco Addiction, Susceptibility To

Nicotine Addiction

Tobacco Use Disorder

Smoking Habit

Nicotine Dependence, Protection Against

Nicotine Addiction, Protection From

Cigarette Habituation

Cigarette Habituation, Susceptibility To

Smoking Habit, Susceptibility To

Nicotine Dependence, Susceptibility To

Nicotine Addiction, Susceptibility To

Addiction, Tobacco, Susceptibility To

Compulsive Tobacco User Syndrome

Tobacco Dependence

Tobacco Dependence Syndrome

Cigarette Addiction

Cigarette Dependence

Smoking Addiction

Smokers Syndrome
Pathological Gambling

Compulsive Gambling

Gambling

Gambling, Pathological

Addiction

Betting

Addiction

Gambling

Betting

Pathological

Gambling

Dependence
Status Epilepticus

Grand Mal Status Epilepticus

Grand Mal Status

Gcse

Generalized Convulsive Status Epilepticus

Se

Epilepsy With Status Epilepticus
Anxiety

Anxiety Disorder

Anxiety Disorders

Anxiety State

Anxieties

Anxiety Neurosis
Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To
Central Nervous System Disease

CNS

Cns Diseases

Central Nervous System Diseases

Cns Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05822 GRM2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05823 Grm2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05824 Grm2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus GRM2 RGD RGD:2743
Macaca mulatta GRM2 VGNC VGNC:73286
Bos taurus GRM2 VGNC VGNC:29659
Mus musculus GRM2 MGD MGI:1351339
Canis familiaris GRM2 VGNC VGNC:41509
Felis catus GRM2 VGNC VGNC:67477
Others GRM2 NCBI
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