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  2. Il3 - interleukin 3 Gene

Il3 - interleukin 3 Gene

中文名称:白细胞介素 3

种属: Rattus norvegicus

基因 ID: 24495 | 基因类型: protein coding

关于 Il3

Primary_assembly 10: 38,405,716-38,408,066 reverse strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 42 orthologues and is associated with 29 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白可启动细胞因子活性和白细胞介素 3 受体结合活性。参与多个过程,包括造血;细胞群增殖的正向调节;和细胞生长的调节。位于细胞外空间。用于研究骨肉瘤。前列腺肥大和肾盂肾炎的生物标志物。该基因的人类直系同源物与格雷夫斯病有关;哮喘;和类风湿性关节炎。与人 IL3(白细胞介素 3)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables cytokine activity and interleukin-3 receptor binding activity. Involved in several processes, including hemopoiesis; positive regulation of cell population proliferation; and regulation of cell growth. Located in extracellular space. Used to study osteosarcoma. Biomarker of prostatic hypertrophy and pyelonephritis. Human ortholog(s) of this gene implicated in Graves' disease; asthma; and rheumatoid arthritis. Orthologous to human IL3 (interleukin 3). [provided by Alliance of Genome Resources, Apr 2022]

Il3 基因产物(1)

mRNA Protein Name
NM_031513.2 NP_113701.2 interleukin-3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cytokine activity IDA
IDA: 通过直接分析推断
3263940 RGD
enables cytokine activity IMP
IMP: 通过突变表型推断
3086845 RGD
enables interleukin-3 receptor binding IMP
IMP: 通过突变表型推断
3086845 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in hemopoiesis IMP
IMP: 通过突变表型推断
9573350 RGD
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
3263940 RGD
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
9573350 RGD
involved in regulation of cell growth IMP
IMP: 通过突变表型推断
3086845 RGD
involved in response to hormone IMP
IMP: 通过突变表型推断
3086845 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
9573350 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Il3 蛋白结构

IL3

IL3: pfam02059 (33 - 139)

  • 0
  • 100
  • 166 a.a.
蛋白主名 其他名称

interleukin-3

IL-3

MCGF

P-cell-stimulating factor

hematopoietic growth factor

mast cell growth factor

multipotential colony-stimulating factor

重组 Il3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73208 IL-3 Protein, Rat (sf9, His) P97688 (I27-C169) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Il3 NCBI NCBI:3562
Canis familiaris Il3 NCBI NCBI:481497
Macaca fascicularis Il3 NCBI NCBI:102118362
Mus musculus Il3 NCBI NCBI:16187
Macaca mulatta Il3 NCBI NCBI:706946