2. Gene
  3. Il3 - interleukin 3 Gene

Il3 - interleukin 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：白细胞介素 3

种属: Mus musculus

同用名: BPA; PSF; HCGF; Il-3; MCGF; Csfmu

基因 ID: 16187 | 基因类型: protein coding

关于 Il3

Chromosome 11: 54,156,129-54,158,103 reverse strand.GRCm39:CM001004.3

This gene has 1 transcript (splice variant), 42 orthologues and is associated with 10 phenotypes.

功能概要

该基因编码的蛋白可启动细胞因子活性；生长因子活性；和白细胞介素 3 受体结合活性。作用于多个过程的上游或内部，包括细胞表面受体信号通路；单核细胞分化；磷酸盐代谢过程的调节。位于细胞外空间。在皮肤中表达；胃;胸腺;和血管系统。该基因的人类直系同源物与格雷夫斯病有关；哮喘;和类风湿性关节炎。与人 IL3（白细胞介素 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables cytokine activity; growth factor activity; and interleukin-3 receptor binding activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; monocyte differentiation; and regulation of phosphate metabolic process. Located in extracellular space. Is expressed in skin; stomach; thymus; and vascular system. Human ortholog(s) of this gene implicated in Graves' disease; asthma; and rheumatoid arthritis. Orthologous to human IL3 (interleukin 3). [provided by Alliance of Genome Resources, Apr 2022]

Il3 基因产物(1)

mRNA Protein Name
NM_010556.4 NP_034686.2 interleukin-3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cytokine activity IDA
IDA: 通过直接分析推断
1350248 MGI
enables growth factor activity IDA
IDA: 通过直接分析推断
7957045 MGI
enables interleukin-3 receptor binding IPI
IPI: 通过物理相互作用推断
19109256 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of B cell apoptotic process IDA
IDA: 通过直接分析推断
7736574 MGI
acts upstream of B cell proliferation IDA
IDA: 通过直接分析推断
7736574 MGI
acts upstream of JNK cascade IDA
IDA: 通过直接分析推断
14967141 MGI
acts upstream of JNK cascade IMP
IMP: 通过突变表型推断
14967141 MGI
acts upstream of T cell proliferation IDA
IDA: 通过直接分析推断
12714518 MGI
acts upstream of or within activation of Janus kinase activity IDA
IDA: 通过直接分析推断
8378315 MGI
acts upstream of cell population proliferation IDA
IDA: 通过直接分析推断
1350248 MGI
acts upstream of cell population proliferation IGI
IGI: 通过遗传相互作用推断
7690439 MGI
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: 通过直接分析推断
7519779 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: 通过直接分析推断
11527400 MGI
acts upstream of hematopoietic progenitor cell differentiation IGI
IGI: 通过遗传相互作用推断
1375116 MGI
acts upstream of or within interleukin-3-mediated signaling pathway IDA
IDA: 通过直接分析推断
19109256 MGI
acts upstream of mast cell apoptotic process IDA
IDA: 通过直接分析推断
12714518 MGI
acts upstream of mast cell proliferation IDA
IDA: 通过直接分析推断
12714518 MGI
acts upstream of or within monocyte differentiation IGI
IGI: 通过遗传相互作用推断
19109256 MGI
acts upstream of myeloid cell apoptotic process IDA
IDA: 通过直接分析推断
10652277 MGI
acts upstream of or within myeloid cell apoptotic process IDA
IDA: 通过直接分析推断
9202146 MGI
acts upstream of myeloid leukocyte differentiation IGI
IGI: 通过遗传相互作用推断
1375116 MGI
acts upstream of or within negative regulation of B cell apoptotic process IDA
IDA: 通过直接分析推断
7736574 MGI
acts upstream of or within negative regulation of autophagy IDA
IDA: 通过直接分析推断
15680329 MGI
acts upstream of or within negative regulation of mast cell apoptotic process IDA
IDA: 通过直接分析推断
12714518 MGI
acts upstream of or within negative regulation of myeloid cell apoptotic process IDA
IDA: 通过直接分析推断
10652277 MGI
acts upstream of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
10872802 MGI
acts upstream of or within positive regulation of B cell proliferation IDA
IDA: 通过直接分析推断
7736574 MGI
acts upstream of or within positive regulation of JNK cascade IDA
IDA: 通过直接分析推断
14967141 MGI
acts upstream of or within positive regulation of JNK cascade IMP
IMP: 通过突变表型推断
14967141 MGI
acts upstream of or within positive regulation of T cell proliferation IDA
IDA: 通过直接分析推断
12714518 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
1350248 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
7690439 MGI
acts upstream of or within positive regulation of hematopoietic progenitor cell differentiation IGI
IGI: 通过遗传相互作用推断
1375116 MGI
acts upstream of or within positive regulation of mast cell proliferation IDA
IDA: 通过直接分析推断
12714518 MGI
acts upstream of or within positive regulation of myeloid leukocyte differentiation IGI
IGI: 通过遗传相互作用推断
1375116 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
7519779 MGI
acts upstream of or within positive regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
14967141 MGI
acts upstream of or within protein dephosphorylation IDA
IDA: 通过直接分析推断
12944463 MGI
acts upstream of protein phosphorylation IDA
IDA: 通过直接分析推断
14967141 MGI
acts upstream of or within regulation of cell growth IGI
IGI: 通过遗传相互作用推断
19109256 MGI
acts upstream of or within regulation of gene expression IDA
IDA: 通过直接分析推断
9697835 MGI
acts upstream of or within regulation of glycolytic process IGI
IGI: 通过遗传相互作用推断
17437992 MGI
acts upstream of or within response to hypoxia IGI
IGI: 通过遗传相互作用推断
17437992 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
7690439 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Il3 蛋白结构

IL3

IL3: pfam02059 (34 - 137)

  • 0
  • 100
  • 166 a.a.
蛋白主名 其他名称

interleukin-3

P-cell-stimulating factor

hematopoietic growth factor

mast cell growth factor

multipotential colony-stimulating factor

重组 Il3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7062A IL-3 Protein, Mouse (His) P01586 (D33-C166) ≥95%
HY-P7062 IL-3 Protein, Mouse P01586 (D33-C166) ≥95%
HY-P70685 IL-3 Protein, Mouse (HEK293, His) P01586 (A27-C166) ≥95%
HY-P73207 IL-3 Protein, Mouse (HEK293) P01586 (A27-C166)/NP_034686.2 ≥95%
HY-P78313 IL-3 Protein, Mouse (HEK293, Fc) P01586 (A27-C166) ≥95%
HY-P700205AF Animal-Free IL-3 Protein, Mouse (His) P01586 (D33-C166) ≥95%

相关产品

Approval
生物活性分子 (4)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B1402 Hydrocortisone hemisuccinate Inhibitor 99.83% 否
HY-B1402B Hydrocortisone hemisuccinate sodium Inhibitor 99.66% 否
HY-B1402A Hydrocortisone hemisuccinate hydrate Inhibitor / 否
HY-B1402R Hydrocortisone hemisuccinate (Standard) / 否
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99536 Tagraxofusp Inhibitor / 否
Clinical Phase
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P99395 Talacotuzumab Inhibitor 98.82% Phase 3
HY-P99234 Pivekimab Inhibitor 96.12% Phase 1
Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-112378 D-65476 Inhibitor / 否
HY-121874 EP009 Inhibitor / 否
HY-155951 JAK3-IN-14 Inhibitor 99.32% 否
HY-P1111 Lyn peptide inhibitor Inhibitor / 否
HY-P1111A Lyn peptide inhibitor TFA Inhibitor / 否
HY-RS06751 IL3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06752 Il3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06753 Il3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06764 IL3RA Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-14271 Acreozast / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Il3 NCBI NCBI:3562
Canis familiaris Il3 NCBI NCBI:481497
Macaca fascicularis Il3 NCBI NCBI:102118362
Rattus norvegicus Il3 NCBI NCBI:24495
Macaca mulatta Il3 NCBI NCBI:706946
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z